1.Modern Research Progress of Relationship between Heart and Emotion Xu Y a1, Li Pengtao2
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(6):1451-1455
Heart dominating mind is one of the main contents in the visceral manifestation theory of tradi-tional Chinese medicine ( TCM ) theory . This article summed up documents , clinical studies , basic experimental studies , and modern scientific researches to review the research results of the relationship between heart and emotion . The connotation of heart dominating mind theory in modern biology was interpreted . And the scien-tificity of TCM theory was explained .
2.Evaluation of spatiotemporal image correlation on fetal cardiac systolic function in normal pregnancy
Xu ZHAO ; Ya YANG ; Rongjuan LI
Chongqing Medicine 2013;(25):2961-2963
Objective To investigate the evaluation value of spatiotemporal image correlation (STIC) on fetal cardiac systolic function .Methods The fetal cardiac cycle images were collected by the four-dimensional(4D) STIC ultrasound technique in 160 normal singleton pregnancies .The virtual organ computer-aided analysis(VOCAL) technique was used to measure the ventricular end-systolic volume (VESV) and ventricular end -diastolic volumes(VEDV) .The stroke volume(SV) ,ejection fraction(EF) and cardiac output(CO) were calculated .Results VESV ,VEDV together with SV and CO in normal pregnancy were increased with gestation week increase .EF remained constant with advancing gestational week .VESV ,VEDV ,SV ,CO and EF of right ventricle were all larger than those of the left ventricle .Conclusion The fetal cardiac systolic function in normal pregnancy is increased with gestational age increase ,the right heart systolic function is superior to the left heart .
3.Relationship between cognitive emotion regulation and behavioral inhibition/activation system of adolescents
Yanzhang LI ; Li XU ; Ya KUANG ; Yun XU
Chinese Journal of Behavioral Medicine and Brain Science 2013;(1):53-55
Objective To explore the relationships between cognitive emotion regulation and behavioral inhibition system(BIS)/behavioral activation system (BAS) of adolescents.Methods Seven hundreds forty-two adolescents were tested by Behavioral Inhibition/Activation System Scale(BIS/BAS Scale) and Cognitive Emotion Regulation Questionnaire Chinese version (CERQ-C).Results (1) Maladaptive emotion regulation,such as selfblame,rumination,catastrophizing and blame others were positively corrected with BIS (r =0.13 ~ 0.38,P <0.01).But adaptive ER had no significantly correlations with BIS (r =-0.05,P > 0.05).Maladaptive emotion regulation was positively correlated with BAS (r =0.24,P < 0.01),and adaptive emotion regulation was negatively correlated with BAS(r =-0.028,P< 0.01).(2)Except acceptance,BIS/BAS had significant effect on the other eight cognitive emotion regulation(P < 0.01).Conclusion BIS/BAS are closely related with cognitive emotion regulation,and have important influences on selection of adolescents'cognitive emotion regulation.
4.Protective effect of tetrahydroxystilbene glucoside on hippocampal neurons damage induced by glutamate in rats
Ya-li LI ; Ling ZHAO ; Yan-ling XU ; Lin LI
Chinese Journal of Rehabilitation Theory and Practice 2004;10(12):751-753
ObjectiveTo observe the protective effect of tetrahydroxystilbene glucoside (TSG) on rats' hippocampal neuronal damage induced by glutamate (Glu) in the culture.MethodsHippocampus was isolated from newborn SD rats and dispersedly cultured in the medium for 9 days. Neurons were incubated with TSG (5—100μmol/L) for 24h, the cells were washed twice with Lock's solution without Mg2+,then Glu 500 μmol/L was added. Thirty min later, the reaction was terminated by washing the monolayer cells twice with the Lock's solution and then cultures were kept at 37℃ for 24h. Cell viability was measured by MTT method and cell membrane damage was determined by LDH leakage; with Fluo-3/AM as an intracellular calcium indicator and added into the bathing medium, fluorescent intensity of intracellular free calcium were observed through laser scanning confocal microscopy (LSCM).ResultsAfter the treatment with 5—100μmol/L TSG for 24h, the decrease of cell viability and the increase of LDH leakage caused by Glu was obviously resisted dose dependently. TSG inhibited increase of Ca2+ in cytoplasm, compared with model group.ConclusionTSG can significantly promote the cell viability and reduce the cell membrane damage in Glu treating hippocampal neurons. The neuroprotective activities of TGS is mediated by inhibiting Ca2+ overload in cytoplasm.
5.Effects of propofol on metabolism of neurotransmitters in different regions of CNS in healthy volunteers
Hui ZHANG ; Li-Xian XU ; Ya-Li GE ; Al ET ;
Chinese Journal of Anesthesiology 1995;0(12):-
Objective To investigate the changes in the metabolism of neurotransmitters in different regions of the brain induced by propofol in healthy volunteers using the proton magnetic resonance spectroscopy (MRS) technology.Methods IH-MRS was performed in ten 20-40 year old healthy volunteers. Each volunteer underwent MRS scan twice. The first MRS scan was performed when they were conscious as baseline control value. The second scan was performed during target-controlled infusion (TCI) of propofol. The target effect-site concentration was set at 3.0 ?g?ml-1. Volume of interest (VOI) included sensory cortex, motor cortex, thalamus, hippocampus and basal ganglia. The metabolites in the spectra included N-acetyl-aspartic acid (NAA), glutamic acid (Glu), GABA, choline compounds (Cho) and creatine (Cr) .Results During TCI of propofol MAP and RR were significantly decreased ( P 0.05) as compared to the baseline value when the volunteers were conscious. During TCI of propofol the NAA content in thalamus and hippocampus, Glu content in thalamus, hippocampus and basal ganglia and Cho content in all the 5 regions of the brain were significantly decreased ( P
6.Effect of Panax notoginseng saponins on myocardial Gs? mRNA expression of seriously scalded rat
Haigang ZHANG ; Xiaohui LI ; Shuhui LI ; Hongmei XU ; Ya TAN ;
Chinese Traditional and Herbal Drugs 1994;0(11):-
Object To investigate the effects of Panax notoginseng saponins (PNS) on myocardial Gs? mRNA expression of seriously scalded rat. Methods A 30% skin full thickness scald model was produced by immersing rat in 95 ℃ water for 10 s. The effects of PNS on myocardial Gs? mRNA level were observed with dot blotting hybridization and in situ hybridization technique; effects on cAMP and adenyl cyclase (AC) activities were determined with radioimmunoassay. Results Myocardial Gs? mRNA, AC activity and cAMP content were reduced significantly 3 h after scalding. PNS (100, 200 mg/kg) could markedly increase the level of myocardial Gs? mRNA expression. The elevated quantity was correlated markedly with PNS dosage (r = 0.95, P
8.Analysis of apnea in 229 cases of very low birth weight infants.
Xiu-jing WU ; Ya-ping XU ; Li-ping SHI
Chinese Journal of Pediatrics 2003;41(8):622-623
Apnea
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epidemiology
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pathology
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therapy
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Birth Weight
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China
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epidemiology
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Female
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Gestational Age
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Humans
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Infant, Newborn
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Infant, Very Low Birth Weight
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Male
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Risk Factors
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Time Factors
9.Relationship between condition of hypoxia and prognosis in patients with renal clear cell carcinoma
Ya ZHOU ; Ran XU ; Minggen YANG ; Songchao LI ; Xiaokun ZHAO
Chinese Journal of Urology 2012;33(8):598-602
Objective To explore the relationship between condition of hypoxia and prognosis in patient with renal clear cell carcinoma (RCCC).Methods The expression of hypoxia-inducible factor-lo( HIF-1 α) protein in cancer tissue of 89 RCCC cases was examined by streptavidin-biotin complex immunohistochemistry.Clinical and pathological data and prognosis of 89 cases were analyzed retrospectively.There were 66 males and 23 females,with an average age of 57 years.The patients were divided into two groups,the chronic pulmonary disease (CPD) group ( 19 cases) and non CPD (NCPD) group (70 cases),with 46cases in clinical stage I,15 cases in stage Ⅱ,26 cases in stage Ⅲ,and 2 cases in stage Ⅳ.The relationship between survival time and clinicopathological variables including the presence of CPD,the positive rate of HIF-1α protein,smoking history and hemoglobin level were evaluated by the Kaplan-Meier method.And the Cox proportional hazards regression model was build to analyze the correlation between each variable and survival time.Results The 89 cases were followed up for a median time of 19 months (6 to 84 months).Twenty cases died,and 69 cases survived.Between the CPD group and NCPD group,clinical stage,hemoglobin level and the degree of expression of HIF-1 α were significantly different (P < 0.05 ).The median survival time was 44 and 71 months in CPD group and NCPD group,respectively,and the difference was significant ( P < 0.05 ).The median survival time was 43 and 70 months in Hb≤ 110 g/L group and Hb > 110 g/L group,respectively,and the difference was significant ( P < 0.05).The stronger the degree of expression of HIF-lα was,the shorter the overall survival was.And the difference was significant ( P <0.05 ).Associated with CPD,hemoglobin level,the expression of H1F-1α were independent factors affecting overall survival of the patients (P <0.05 ).CPD and HIF-1 α expression were positively related to disease-free survival time,and hemoglobin level was negatively related to disease-free survival time.Conclusions Systemic hypoxia caused by CPD may aggravate the hypoxie state in the organization of the patients with RCCC.The condition of hypoxia and prognosis in patient with RCCC is negatively correlated.
10.Analysis of clinical factors in achalasia complicated by esophageal cancer
Ya LI ; Ruifeng SONG ; Weiwei HAO ; Lei YANG ; Feng XU
Chinese Journal of Digestion 2017;37(8):543-546
Objective To analyze the clinical pathological characteristics of achalasia patients complicated by esophageal cancer.Methods From January 2005 to May 2013,among 658 patients with achalasia,the clinical data,pathological characteristics of tumor and the treatment of those complicated by esophageal cancer were collected and analyzed.At the same time,receiver operating characteristic (ROC) curve analysis was performed to analyze the relationship between the course of achalasia and esophageal cancer.Results Among the 658 patients with achalasia,297(45.1%) cases were male and 361(54.9%) cases were female.A total of 62 cases (9.4%) were lost to follow-up and of 596 cases who completed the follow-up,26 cases (4.4 %) were complicated with esophageal cancer.Among the 26 patients complicated with esophageal cancer,69.2% (18/26) were male;the course from achalasia diagnosed to esophageal cancer was (16.5±8.2) years.The patients with a disease duration more than 10 years accounted for 88.5%(23/26),and 80.8% (21/26) underwent previous balloon dilatation or Heller surgery.The predilection site of esophageal cancer was in the middle esophagus of patients complicated by esophageal cancer (69.2%,18/26),the main type was squamous carcinoma (88.5%,23/26),65.4%(17/26) of the lesions invaded to muscular layer (stage T3 to T4),61.5%(16/26) had the late stage tumor (stage Ⅲ to Ⅳ),and 23.1%(6/26) had distant metastasis.The results of ROC curve analysis showed that when the duration was 10.5 years,the Youden index reached the maximum value (0.71).And 38.5% (10/26) of patients with esophageal cancer could not be treated with esophageal cancer radical surgery,and their average survival time was (11.4±6.6) months.Conclusion The patients with the duration of achalasia over 10.5 years are required for regular endoscopic examination to improve the prognosis.