Objective To understand the total score of health management knowledge demand and self evaluation score of known health management knowledge,in order for hospitals to take more reasonable and effective health management education for patients after discharge.Methods From March to May of 2012,700 patients in a certain three level of first-class general hospital were selected before their discharge,using self-made health management questionnaire for investigation.The total score of health management knowledge demand and score of known health management knowledge among 700 patients with different demographic characteristics underwent statistics.Results After investigation,the results showed that patients with different nationalities,payment method,the average monthly income,family history,residence and intend demonstrated statistical significance in total score of health management knowledge requirement.Patients with different occupation,culture degree and accept frequency showed statistical significance in known health management knowledge.Conclusions According to the current investigation of total score of different health management knowledge demand and known health management knowledge in patients with different demographic characteristics,the hospital should take corresponding adjustment for health management mission to ensure the health management quality of patients after discharge,and improve the health management level of patients after discharge.

Objective To study the curative effect on refractory frequent ventricular premature beat(VPB) by radiofrequency catheter ablation.Methods The refractory frequent ventricular extrasystoles of 18 patients were treated by radiofrequency catheter ablation(RFCA).The way of ventricular excited sequence and pacemaker-mapping was used to map and locate the site of VPB origin.When the original site of eliciting premature beat,where the excitation point of VPB appeared 20ms earlier than QRS waves of surface EKG or QRS waves of ablation electrode pacing electrogram were completely coincident with QRS waves of VPB,was localized,the frequency current should be delivered in situ.Results 18 patients were all successful,the success rate was 100%.No intraoperative or postoperative complications happened.Conclusion RFCA is an effective and safe surgical approach for frequent ventricular ectopic beats.

Objective To evaluate the efficiency and safety of emergency intracoronary stenting for senile patients with acute myocardial infarction(AMI).Methods Fifty senile patients undergone successful intracoronary stenting were analyzed.Results Among these patients,infact-related arteries(IRA) were LAD in 26 patients,LCX in 16 patients,RCA in 8,sixty-eight stents of 5 kinds were implanted.Residual stenosis decreased from 95%～100% to 10%～-5%(P

Radiotherapy is a major local treatment for cervical cancer.However, local uncontrollability due to radioresistance is still common.Therefore, the prediction of radiosensitivity is quite beneficial to develop an optimal treatment strategy for individual patients.Multiple factors could influence the radiosensitivity of cells, and p53 status is one of them.The upstream or downstream molecules of p53 could also be regulated to affect the radiosensitivity of cervical cancer.The aim of the review is to analyze the difference in p53 status between different types of cervical cancer and to discuss how p53 regulates the response to radiotherapy.

Aldosterone and metabolic syndrome are known cardiovascular risk factors associated with increased morbidity and mortality. This review focuses on the recent advances and clinical significance of the relationship between aldosterone and each single component of metabolic syndrome. The possible role of aldosterone receptor antagonist or aldosterone synthetase inhibitor in the treatment of metabolic syndrome is discussed.

Objective To elucidate the relationship between hepatic histopathologic progression and findings of clinical noninvasive examination in patients with non-viral liver diseases. Methods A total of 222patients withnon-viral liver diseases, who received liver biopsy in our hospital, were included in the present study. The association of different histopathological progression (grade of hepatic inflammation and stage of fibrosis) with the noninvasive examination parameters (serum biochemical indicators and imaging findings) was investigated. Results We found that age, serum biochemical indicators, platelet(PLT), and ratios of aspartate aminotransferase to platelet (AST/PLT), aspartate aminotransferase to alanine aminotransferase (AST/ALT) and albumin to globulin (A/G) were significantly associated with the histopathological grades and stages of hepatictissues. The grades of inflammation were markedly different between 2 groups with ALT levels higher or lower than 1 upper limits of normal (ULN)(P=0.009); the stages of hepaticfibrosis were significantly different between 2 groups with ALT levels higher or lower than 2 ULN (P=0.030).The result of B-type ultrasonic examination was positively related to the grade of hepatic inflammation and stage of fibrosis(r=0.417,P=0.000;r=0.530,P=0.000). AST/PLT and prothrombin time (PT) levelwer significantly different between patients with hepatic fibrosis and those without(P=0.015, P=0.000); AST/ALT, AST/PLT, A/G and PT levels were also significantly different between cirrhotic patients and non cirrhotic cones (P=0.042,0.012,0.000, and 0.003, respectively). The area under ROC curve of non invasive analysis model APRI was the largest one among the 3 models. APRI model had the highest sensitivity in diagnosing liver fibrosis, but with a poor specificity; S-Index had a higher specificity but a poor sensitivity. Conclusion Clinical noninvasive parameters are valuable for evaluating the activity of Hepatic inflammation and stage of fibrosis in patients with non-viral liver diseases. Noninvasive analysis model is useful for diagnosing liver fibrosis and early cirrhosis.

To study the anti-cancer activity of the three anti-oncoprotein p185 mAbs established by surface epitope masking method so as to provide some basic information for clinical tumor targeting therapy.Methods: Immnune flurorence staining, MTT assay, soft-ar-gar culture and long-term cell proliferation assay detected the suppressive activities of the mAbs against the breast cancer cells overexpressing p185 and p185-transfected fibroblast cells, and the inducing effects of the mAbs on tumors sensitivity to chemotherapy.Results:The 3 mAbs specifically suppressed tumor cell proliferation and enhanced the sensitivity of tumors to chemotherapeutics. Conclusion:These mAbs have the potentials to develop into the clinical tumor targeting therapeutic reagents of the tumors overexpressing p185.

Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Cisplatin ; administration & dosage ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Fluorouracil ; administration & dosage ; Humans ; Intestinal Neoplasms ; drug therapy ; Lung Neoplasms ; drug therapy ; Male ; Phytotherapy ; Tetrahydrofolates ; administration & dosage

Objective To evaluate the effect of biofeedback therapy for the treatment of myogenic fecal incontinence. MethodsA general assessment about anorectal function was made on 17 cases receiving biofeedback therapy including muscle power training,sensory training and coordination training. Results The clinical scores before and after biofeedback therapy were 1.66?0.23,3.80?0.42 respectively,with an effective rate of 82%. The anus maximum contracting pressure elevated,(73?20) mm Hg vs. (123?30) mm Hg; myoelectric amplitude increased,(122?32) ?V vs. (230?41) ?V;Contracting time prolonged,(4.1?2.0) s vs. (9.4?3.0) s; The sensory threshold was lowered,(50?12) ml vs. ( 20? 10) ml;The feel-contract time increased,(3.1?0.4) s vs. (1.2?0.3) s. Positive rectal contraction reflex was seen in 41% patients before therapy compared with 82% after therapy. Conclusions Biofeedback therapy increases contractility of sphincter,decreases threshold of rectal sensory,and is a therapy of choice for myogenic fecal incontinence.

The aim of this study is to investigate the influence of different posts on the fracture mechanics of endodontically-treated teeth with open apex. Forty-eight human maxillary anterior teeth were collected, and the root was transversely sectioned 12 mm under the cementoenamal junction (CEJ). These samples were then randomly divided into two groups, i.e., minor diameter open apex root (group A) and major diameter open apex root (group B), with mineral trioxide aggregate (MTA) placed into the apical 4 mm in the root canals. Subsequently, both groups were respectively further divided into three subgroups as follows: fiber-post (subgroup 1), metal post (subgroup 2) and non-post (subgroup 3) group. Teeth were restored with a composite resin crown and tested by using a universal testing machine at the rate of 1 mm/min cross-head. Values of the maximum fracture resistance and failure patterns were recorded and compared among all subgroups. In addition, the changes of MTA properties were carefully examined via X-ray photography. Our results indicate that (1) In group A, the mean value of fracture resistance for teeth restored with fiber posts were statistically higher than that with either metal post or non-post; (2) In group B, there was no statistically significant difference in the mean value of fracture resistance among three subgroups; (3) No statistical significance in the mean value of fracture resistance was found between group A and group B; (4) The failure modes of most samples (58%) were irreparable; (5) MTA in two teeth developed cracks after loading tests. In conclusion, endodontically-treated teeth restored with fiber posts are more resistant to fracture than those restored with either metal posts or non-post, and most of the fracture modes are catastrophic in nature.