Triple-negative breast cancer (TNBC) in elderly patients presents distinctive clinicopathologic characteristics of large volume and histological grade Ⅲ,and it is seen most frequently in invasive ductal carcinoma,adenocarcinoma and lobular carcinoma.Elderly women with TNBC significantly benefit from adjuvant chemotherapy.But older women frequently have concurrent disease,so neoplasm staging,function of vital organs and tolerance of patient should be considered when treatment programs are selected.The prognosis of older TNBC patient is worse,but rational therapy can improve outcomes significantly.

It is important and challenging for geriatricians and general practitioners to detect early and diagnose senile dementia in outpatient setting.After providing the definition of dementia,this article will discuss prompt recognition of dementia based on symptoms and signs, the neuropsychological assessment,and the biomarkers of dementia,as well as differential diagnoses.

OBJECTIVE: To observe the clinical efficacy of nimodipine combined with Shengmai injection on hypertensive cerebral hemorrhage. METHODS: 24 patients with hypertensive cerebral hemorrhage hospitalized within 24 hours of symptom onset were randomly divided into control group and treatment group. Both groups were given routine treatment, including reducing intracranial pressure and blood pressure and nourishing brain cells. Treatment group were additionally given nimodipine and Shengmai injection. The intracranial hematoma, perihematomal edema and CSS score were observed and compared between two groups as well as clinical efficacy. RESULTS: After 2 weeks of therapy, the level of intracranial hematoma, perihematomal edema and CSS score of treatment group were lower than that of control group, with statistical significance (P

Objective: To identify the existence of the specific NMP in the human normal colon tissues and different differentiation of colon carcinoma,and try to study the association between changes of nuclear matrix protein and biological behaviar of colorectal colon carcinoma.Methods:Two-dimensional gel electrophoresis was used in the analysis of 12 matched human colon carcinomas and adjacent normal samples.MMP-9 and CB were detected by immunohistochemical SP method.Results: Analysis of multiple gels for each sample revealed that 5 proteins were present in tumor samples,but not in the matched normal colon tissues;and 3 proteins in normal colon tissues but not in the colon carcinomas.There were different NMPs in different types of colon carcinoma.One nuclear matrix protein(called N4) appeared in 9 moderate-well differentiational colon carcinomas without lymph node metastasis and in 12 normal colon tissues,but were absent in 3 poor differentiational colon carcinomas with lymph node metastasis.The result of immunohistochemistry showed that the expression of MMP-9 and CB in poor differentiational colon carcinoma which was lack of expression of NMP N4 was strongly positive,and was stronger than that in the moderate-well differentiational colon carcinomas which expressed NMP N4.Conclusion: The data suggests that there are colon carcinoma-specific NMPs.There are different NMPs in different types of colon carcinomas,and with or without lymph node metastasis.Colon carcinoma-specific NMPs may serve as the tumor markers of colon carcinoma in future.There is a relation between changes of nuclear matrix protein and lymph node metastasis of colorectal colon carcinoma;the changes of NMPs probably play a role in MMP-9 and CB expression of colon carcinoma.

Objective To compare effect of GLEDI and alteplase on acute ischemic stroke. Methods 120 patients were randomly recruited into a GLEDI group and a alteplase group, and treated with the corresponding medicine respectively.The changes of NIHSS and hemorheology were observed. Results NISS and hemorheology in both groups were declined.There was statistic difference (P＜0.05). The GLEDI group had a greater decline in ESR than the alteplase group, showing statistic difference (P＜0.05). Conclusion Both GLEDI and alteplase were effective in treating acute ischemic stroke. They have relatively same effects ifthey were used to a full therapeutic course.

With the development of medical radiography, cone beam computed tomography (CBCT) has been widely used in stomatology because of its numerous advantages, such as adequate spatial resolution, low radiation, undistorted three- dimensional tissue information, and good applicability for hard tissue imaging. Traditional periapical radiography is based on two-dimensional image which displays the three-dimensional object and its surrounding structures. Periapical radiography can only show the overlapping mesio-distally direction bone destruction, can't show buccolingual direction bone destruction. As a kind of three-dimensional imaging technology, CBCT can show three-dimensional structure of the organization from sagittal, coronal and axial direction, to overcome the defect of two-dimensional image such as overlap and deformation. CBCT has a unique advantage than periapical radiography in the diagnosis and treatment for periapical disease. This review will summarize the difference between CBCT and periapical radiography in the periapical disease.
Cone-Beam Computed Tomography ; Humans ; Imaging, Three-Dimensional ; Periapical Diseases ; diagnostic imaging ; Radiography, Bitewing

Objective To evaluate the effect of oral rehabilitation method combined with Shaker exercise on the swallowing function and the quality of life in the patients with dysphagia caused by cerebral infarction.Methods A total of 120 patients with swallowing disorder caused by cerebral infarction were randomly divided into conventional treatment group (n=30),oral rehabilitation method group (n=30),Shaker exercise group (n=30) and comprehensive therapy group (n=30).The patients in the conventional treatment group were treated with conventional treatment,while the patients in oral rehabilitation method group received oral rehabilitation method treatment in addition.The Shaker exercise group accepted Shaker exercise and conventional treatment,while the comprehensive therapy group accepted oral rehabilitation method in addition.All patients were assessed with video fluoroscopic swallowing study (VFSS) and swallowing-related quality of life (SWAL-QOL),before treatment and 4-week after treatment.Results Before treatment there was no significant difference among the four groups in VFSS and SWAL-QOL scores (P＞0.05).After 4-week treatment the swallowing function showed different degrees of improvement.The difference of VFSS score in the conventional treatment group was not statistically significant before treatment and 4-week after treatment (P=-0.38),but it was statistically significant among the other three groups (P＜0.01).After 4-week treatment there was significant difference among the four groups in VFSS score (P＜0.01),and the comprehensive therapy group curative effect was significantly better than that of the other groups.The total effective rate was 96.67％ in the comprehensive therapy group,26.67％ in the conventional treatment group,66.67％ in the oral rehabilitation method group,and 70.00％ in the Shaker exercise group.the SWAL-QOL score in the comprehensive therapy group was higher than that of the other three groups.The average SWAL-QOL score was 187.30±10.68 in the comprehensive therapy group,(140.10±16.62) in the conventional treatment group,(161.47 ±24.53) in the oral rehabilitation method group,and (163.97 ± 23.91) in the Shaker exercise group.Conclusion Application of oral rehabilitation method combined with Shaker exercise in the patients with swallowing disorder caused by cerebral infarction could effectively improve the degree of swallowing disorder and the quality of life.

In 2014, The Cancer Genome Atlas firstly classified gastric cancer into four types according to genotype. Epstein-Barr virus (EBV) positive gastric cancer or EBV-associated gastric cancer (EBVaGC) is attracting attention because it is a possibly suitable group for immunotherapy. Among the mutations observed in tumors, such as gastric cancer, p53 mutations are the most frequent. In particular, it occurs more frequently in EBVaGC than in EBV-negative gastric cancer (EBVnGC). Meanwhile, EBV infection is considered as an early event of tumorigenesis. The interactions between wild-type p53 proteins and BZLF1 (Z) proteins are essential in maintaining the latent state of EBV infection and promoting early replication. In the latter stages of replication, wild-type p53 proteins are degraded through the ubiquitination of some viral molecules. These findings may indicate the importance of wild-type p53 genes in EBVaGC formation. Inflammatory responses induced by EBV infection, tumor with a large number of lymphocyte infiltration, genome high mutation, and PD-L1 amplification make it possible to become the appropriate group of immunotherapy, which also illustrate that the important role of immune microenvironment during tumor progression. In EBVnGC, extremely high levels of p53 mutation were observed because of several associated factors, and the p53 protein encoded by the mutant p53 gene lost its antitumor function after tumorigenesis. In this review, the possible mechanisms of rare p53 mutation in EBVaGC are summarized.

Objective To investigate the expression of multidrug resistance protein 1 (MDR1) and brain and acute leukemia cytoplasm (BAALC) genes and its relationship with prognosis in patients with newly diagnosed acute myeloid leukemia (AML).Methods A total of 100 adults with newly diagnosed AML were enrolled in the study.All patients were treated with anthracyclines induced chemotherapy combined with cytarabine.The expression levels of MDR1 and BAALC genes were detected,and the relationships with the clinical characteristics of patients with AML,genetic type,therapeutic effect and prognosis were analyzed.Results There was no significant differences in white blood cells,hemoglobin and platelet between patients with high and low expression of MDR1 gene and BAALC gene (P>0.05).There were significant differences in the expression level of MDR1 gene between patients with different chromosome risk stratification (P<0.05) but there was no significant difference in the expression level of BAALC gene (P>0.05).After chemotherapy intervention,CR of patients with high expression of MDR1 gene was significantly lower than patients with low expression of MDR1 gene (60.78% vs.87.76%)(P<0.05),CR of patients with high expression of BAALC gene was slightly lower than patients with low expression of MDR1 gene (67.31% vs 81.25%)(P>0.05).Comparison of median overall survival (OS) and overall survival (OS) in patients with high and low expression of MDR1 gene.The difference was statistically significant (P<0.05).Comparison of median overall survival (OS) and overall survival (OS) in patients with high and low expression of BAALC gene.There was no significant difference(P>0.05).Conclusion Compared with the expression of BAALC gene,the value of expression of MDR1 gene is higher in evaluating the curative effect in patients with newly diagnosed AML.Combined detection of MDR1 and BAALC genes can improve the accuracy in predicting the prognosis of patients.

At present, there is no specific antidote for local anesthetic toxicity, which seriously hindered therapeutic efficts of clinical treatment. It is increasingly urgent for finding find the effective antidote to local anesthetic. This article at-tempts to interpret the molecular pharmacological mechanism from fat pool, energy metabolism, NO, ion channel and solubili-zation for the role of fatty acids in reversal of myocardial toxicity of local anesthetics. And the different characteristics of the structure and function of nano liposome and fat emulsion were compared.