1.Disaster Vulnerability Evaluation of Pharmacy Department in Our Hospital
China Pharmacy 2015;(34):4813-4815
OBJECTIVE:To guide the formulation of emergency management plan for pharmacy department and reduce emer-gency risk. METHODS:By the methods of risk integration,considering the frequency and severity of the hazard events,the risk integral value of emergency events was calculated and hazard level was judged. RESULTS:The top three hazard events of pharma-cy department were information system failures (75.21),fire (63.00) and cytotoxic drugs overflow (62.21). All of the above events were moderate risk. According to the results of this evaluation,pharmacy department targeted emergency drills,in order to improve the ability to cope with risks. CONCLUSIONS:In order to improve the ability of facing and dealing hazard events,disas-ter vulnerability analysis is the base of developing and exercising emergency plans.
3.Risk factors for new-onset diabetes mellitus after kidney transplantation:a retrospective study
Jin YANG ; Fang FANG ; Fu YANG
Chinese Journal of Tissue Engineering Research 2017;21(20):3275-3280
BACKGROUND: Effect of metabolic disorders after kidney transplantation on prognosis, especially new-onset diabetes after transplantation (NODAT), has aroused concerns. OBJECTIVE: To investigate the risk factors for NODAT in renal transplant recipients, thus providing reference for identifying high-risk patients and taking active prevention measures. METHODS: Clinical data of 365 patients undergoing allograft renal transplantation were analyzed retrospectively. According to whether NODAT occurred or not, all the patients were assigned to NODAT (n=71) and non-NODAT (n=294) groups. The independent risk factors for NODAT were determined using univariate and non-conditional multivariate logistic regression analysis. RESULTS AND CONCLUSION: The cumulative incidence of NODAT in renal transplant recipients within year postoperatively was 19.45%. Non-conditional multivariate logistic regression analysis showed that age ≥ 45 years old, body mass index ≥ 25 kg/m2, family history of diabetes mellitus and acute rejection were associated with NODAT in renal transplant recipients. To conclude, the age, family history of diabetes mellitus, high body mass index and acute rejection can increase the incidence of NODAT in renal transplant recipients.
4.Analysis of 111 Cases of Antibiotics-induced ADR Reports in Our Hospital
Zhengze SHEN ; Chuan FU ; Mei JIN
China Pharmacy 2015;(26):3667-3668,3669
OBJECTIVE:To investigate the characteristics and regulation of antibiotics-induced ADR in our hospital and ex-plore effective prevention measures,in order to provide reference for safe and rational use of antibiotics in the clinic. METHODS:111 antiobiotics-induced ADR reports were collected from our hospital during 2012-2014,and analyzed in terms of patient’s gender and age,route of administration,drug category,organs/systems involved in ADR,etc. RESULTS:The patients aged <10 years old and >60 years old took up the highest proportion,accounting for 27.93% and 25.23%,espectively. ADR induced by intrave-nous route of administration had the highest incidence,accounting for 84.68%;cephalosporins-induced ADR was the most,account-ing for 26.13%;lesion of skin and its appendents was main antibiotics-induced ADR,accounting for 44.92%. CONCLUSIONS:Clinical pharmacists should provide technical support to doctors and nurses to aviod the occurrence of ADR.
5.An analyses of 104 cases spontaneous rupture of hepatocellular carcinoma
Jin LI ; Zhengming LEI ; Wenguang FU
Chongqing Medicine 2016;45(27):3783-3784,3787
Objective To investigate the clinical management of Spontaneous rupture of hepatocellular carcinoma(SRHCC) . Methods This was a retrospective review of the clinical data of patients with SRHCC who underwent treated in the affiliate hospi‐tal of Luzhou medical college from January 2001 to December 2014 .Results Among 104 patients ,small hepatocellular carcinoma (<5 cm) were found in 11 cases ,and large hepatocellular carcinoma(>5 cm) in 93 cases .Thirty‐one cases which underwent surgi‐cal treatment ,were cured;44 underwent transcatheter arterial embolization (TAE) ,5 cases died of liver function failure;29 cases were treated conservatively ,11 cases died of huge bleeding ,18 cases gave up discharged .Twenty‐two small and medium‐sized SRH‐CC cases underwent hepatectomy survived 1to‐10 years ;8 huge sized SRHCC cases survived 5to‐13 months;one case who under‐went partial filling pressure hemostasis and hepatic artery ligation ,but died of tumor rupture again after 34 days .Sixteen cases un‐derwent TAE were followed up ,14 cases survived 3to‐10 moths ,the survival time of two cases were 3 years and 5 years ,respective‐ly .Conservative treatment group has not been followed up .Conclusion The tumours should be surgical resection as soon as possi‐ble in those whose lesions confined to the liver and may be removed ,systemic condition is good;TAE should be used for other pa‐tients .
6.Cross-lagged analysis of acute stress disorder, posttraumatic stress disorder and depressive symptoms among children after Lushan earthquake
Lin FU ; Jin CHENG ; Zhengkui LIU
Chinese Mental Health Journal 2017;31(7):548-553
Objective:To examine the relationships between acute stress disorder (ASD) symptoms,posttraumatic stress disorder (PTSD) symptoms and depressive symptoms in children survivors following the Lushan earthquake in China.Methods:One hundred ninety-seven children aged 1 to 14years (93 male and 104 female) were followed up at two and six weeks after Lushan earthquake.The ASDS,UCLA PTSD Reaction Index and DASS were used to measure the ASD,PTSD and depressive symptoms.Results:The average scores of ASDS and the depression subscale of DASS at two weeks after earthquake were(36.5 ± 10.9) and (3.3 ± 2.8),respectively.The average scores of UCLA PTSD Reaction Index and the depression subscale of DASS-21 at six weeks after earthquake were (18.5 ± 12.6) and (3.3 ± 3.5),respectively.The rates of ASD and PTSD were 28.6% and 8.2%,respectively.The cross-lagged structural equation analysis with latent variables indicated that the ASD symptoms at two weeks after earthquake positively predicted PTSD symptoms (β =0.59,p < 0.001) and depressive symptoms (β =0.29,p <0.001) at six weeks after earthquake.But there was no significant association between depressive symptoms at two weeks and PTSD symptoms at six weeks after earthquake.Conclusion:ASD symptoms in the early time postearthquake could predict subsequent PTSD and depressive symptoms,while depressive symptoms tend to remain stable within six weeks after earthquake.
7.Changes of common pathogenic bacteria and their antimicrobial resistance in neonatal infection from 2008 to 2010
Shiwen XIA ; Chunhua FU ; Zhengjiang JIN
Chinese Journal of Perinatal Medicine 2011;14(9):534-539
ObjectiveTo investigate the common pathogenic bacteria and antimicrobial resistance status in neonatal ward to provide guidance for rational clinical medication. MethodsData of 2306 cases in neonatal ward from July 2008 to June 2010 whose body fluid were cultured with positive results of common bacteria were collected. The change of the bacteria and drug resistance was analyzed. Results Among 10 017 body fluid samples, 80 species consisted of 2306 strains of bacteria were found. Enterobacteria accounted for about 53.8% (1241/2306), Klebsiella pneumoniae subsp. pneumoniae (430/1241, 34.6%) and Escherichia coli (341/1241, 27.5%) were the most common ones,and among which 68.1%(293/430)strains of Klebsiella pneumoniaesubsp.pneumoniae and 59.5 % (203/341 ) strains of Escherichia coli were extended-spectrum β-lactamases (ESBLs) producing strains, which were significantly lower than those[78.1% (118/151) and 82.6%(76/92) respectively]during 2003 to 2005 (U=-2.32 and -4.11, P<0.05 respectively).Methicillin-resistant Staphylococcus aureus(MRSA)detectionrate was 8. 5%(23/272)in Staphylococcus, which was lower than that (17.7%, 15/85) in year 2004 to 2006 (U= -2.4, P<0. 05). Methicillin-resistant coagulase-negative Staphulococcus (MRCNS) detection rate was 63.5%(157/247), which was higher than that (32.6%, 97/298) in year 2004 to 2006(U=7.54,P<0.05).The common pathogens of nosocomial infection were Klebsiella pneumoniae subsp.pneumoniae,Escherichia coli , Acinetobacter baumannii and Pseudomonas aeruginosa ; while common pathogens of community infection were Staphylococcus aureus, Klebsiella pneumoniae subsp.pneumoniae and Escherichia coli. Multiple drug-resistant infections in hospital were significantly higher than those in community. Drug susceptibility results showed that the resistance of Staphylococcus haemolyticus,Acinetobacter baumannii and Klebsiella pneumoniae subsp.pneumoniae were especially severe.ConclusionsOpportunistic infections and drug resistant strains increased. The increasing of MRCNS and drug-resistant of Acinetobacter baumanniishouldbepaidmore attention.Comprehensive measures might reduce the production of ESBLs bacteria. The choice of antibiotics should be based on drug susceptibility test.
8.PET/CT in the diagnosis and treatment of pancreatic cancer
Xiaoyi WANG ; Chen JIN ; Deliang FU
International Journal of Surgery 2009;36(9):609-611
PET/CT is a useful method which combines metabolic and anatomic imaging. It has already a-chieved good results in differential diagnosis of pancreatic malignant disease, evaluating therapeutic effect, monitoring tumor recurrence and metastasis. This article will summarize the clinical utilization of PET/CT in the diagnosis and treatment of pancreatic cancer.
9.Protective Effect of Astragalus Membranaceus on Ischemic Acute Renal Failure
Yuxin BAI ; Liang FU ; Jin GAO
Chinese Journal of Experimental Traditional Medical Formulae 2009;(7):74-76
Objective: To investigate the effect of astragalus on the serum levels of hepatocyte growth factor (HGF), renal function and the damage of renal morphology in ischemic acute renal failure (IARF). To study the protective mechanism of astragalus in IARF. Methods: The rats were pretreated with astragalus or vehicle for 3 days. IARF was induced by left renal artery clipping for 60 min, after the right kidney was removed. Biochemical parameters for serum HGF,blood urea nitrogen(BUN),creatinine(Cr) were measured and histological analyses of the kidneys were performed by tubular grading. Results: There have no significant difference between the serum HGF levels of I/R controls and the levels observed in sham-operated group (P > 0.05). Serum HGF levels in astragalus treated group was significantly increased than those of I/R control group(P < 0.01) .After 4 h of I/R, serum levels of BUN and Cr were increased in I/ R control rats compare with Sham-operated rats(P < 0.01). Astragalus treatment reduced the levels elevation(P < 0.05). Simultaneously,. I/R-induced severe damage in renal morphology were significantly ameliorated by astragalus treatment(P < 0.01). Conclusions: Astragalus pretreatment can alleviate the damage of renal function in IARF. It is may be one of the mechanisms of astragalus for protecting renal tissue in IARF that astragalus can induce the expression of HGF.
10.The Clinical Experience of Professor He Ruoping in the Treatment of Bladder Cancer
Chenyu JIN ; Dandan FU ; Ruoping HE
Journal of Zhejiang Chinese Medical University 2015;(5):335-337
Objective] To sum up director doctor He Ruoping’s by stages treatment experience in treating bladder cancer. [Method]By learning from director doctor He Ruoping for many years and combining my own clinical experience, from the etiology and pathogenesis, therapeutic principle of TCM syndrome differentiation treatment characteristics, etc, it sums up the teacher He ’s unique feature of by stages treatment of bladder cancer, and with 1 case for detailed explanation. [Result]Teacher He advocating the combination of traditional Chinese medicine and western medicine, puts forward the principle of by stages treatment to bladder cancer:treatment of postoperative perfusion stage, treatment of following up stage without perfusion and treatment of palliative transfer stage, and makes prescriptions in line with the characteristics of each stage. [Conclusion] Teacher He ’s by stages treatment to bladder cancer obtains the good curative effect, having enlightenment meaning to clinical practice, with promotion value.