Biomarkers, Tumor ; analysis ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Irritable Bowel Syndrome ; pathology ; Lymphoma, B-Cell ; pathology ; Oncogene Proteins, Fusion ; analysis ; Sarcoma, Synovial ; chemistry ; pathology

Autopsy ; China ; Diagnosis, Differential ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Pathology ; manpower ; organization & administration ; standards ; Practice Guidelines as Topic ; Quality Control

Chromogranin A ; metabolism ; Gastrointestinal Neoplasms ; classification ; metabolism ; pathology ; Humans ; Immunohistochemistry ; Neuroendocrine Tumors ; classification ; metabolism ; pathology ; Pancreatic Neoplasms ; classification ; metabolism ; pathology ; Pathology ; standards ; Synaptophysin ; metabolism ; World Health Organization

Biomarkers, Tumor ; genetics ; metabolism ; Humans ; Molecular Targeted Therapy ; standards ; Mutation ; Neoplasms ; drug therapy ; genetics ; metabolism ; pathology

Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Drug Delivery Systems ; methods ; Drug Resistance, Neoplasm ; Humans ; Mutation ; Neoplasms ; drug therapy ; genetics ; pathology

Objective To observe the effect of controlled infusion on patients who underwent laparoscopy for gastrointestinal neoplasms.Methods Eighty patients who underwent laparoscopy for gastrointestinal neoplasms were randomized into the controlled infusion group(n=40)and the normal infusion group(n=40).In the perioperative period(from intraoperatively to 3 days postoperatively),for the controlled infusion group,infusion volume was controlled in a goal-directed manner based on the patient's left ventricular ejection fraction(LVEF),stroke volume variation(svv),central venous pressure(CVP),blood pressure,base excess(BE),hemoglobin,urine volume and additional loss;for the normal infusion group,fluid infusion were performed per routine protocol for surgical fluid infusion.Both groups were compared regarding mean perioperative infusion volume,postoperative time to first flatus,incidence of complications,length of stay(LOS),and hospitalization expenses.Results No significant difference was found in mean perioperative infusion volume between controlled[(2391.9±494.09)ml] and normal[(2432.4±384.14)ml] infusion groups(P>0.05);postoperative time of first flatus,LOS and incidence of complications were markedly lower and hospitalization expenses were markedly less than those in the normal infusion group,and differences were statistically significant(P<0.05).No case of death was noted in either group.Conclusion Goal-directed control of fluid infusion in the perioperative period of laparoscopy for gastrointestinal neoplasms can help reduce the incidence of postoperative complications,shorten the time to gastrointestinal function recovery and LOS,and cut down the hospitalization expenses.

AIM: To study the effect of selective A1 adenosine receptor agonist, 2-chloroadenosine (2-CA), and non-peptide phosphoantigen isopentenyl pyrophosphate (IPP) on the intracellular reactive oxygen species (ROS) at the level of signaling event. METHODS: M1 cell line, derived from a subclone of the SV40-transformed xeroderma pigmentosum (XP) cell line, was treated with 2-CA, 8-br-cAMP, IPP at 37 ℃ incubator for 30 min, and intracellular ROS was measured by flow cytometry and CytoFluorometer. RESULTS: Under an appropriate control, 2-CA and IPP reduced intracellular ROS by 20%-30%. CONCLUSION: The data revealed that 2-CA and IPP inhibited cellular oxidant formation at the level of signaling event, suggesting both may have some anti-oxidant properties in vivo.

Acquired Immunodeficiency Syndrome ; diagnosis ; pathology ; Alzheimer Disease ; diagnosis ; pathology ; Autopsy ; Diagnosis, Differential ; Hepatitis, Viral, Human ; diagnosis ; pathology ; Humans ; Idiopathic Interstitial Pneumonias ; diagnosis ; pathology ; Neoplasms ; diagnosis ; pathology ; Pathology, Molecular ; methods ; Staining and Labeling

Breast Neoplasms ; drug therapy ; genetics ; pathology ; Carcinoma, Ductal, Breast ; drug therapy ; genetics ; pathology ; Carcinoma, Lobular ; drug therapy ; genetics ; pathology ; Cell Nucleus ; pathology ; Female ; Gene Expression Profiling ; Humans ; Immunophenotyping ; Lymphatic Metastasis ; Lymphatic Vessels ; pathology ; Neoadjuvant Therapy ; Tumor Burden

Autopsy ; Biopsy ; Pathology ; education ; Pathology Department, Hospital ; organization & administration ; Pathology, Surgical ; methods ; Quality Control