0.05).The relative bioavailability of experimental preparation vs.reference preparation was(93.80?12.24)%.CONCLUSION:Telmisartan capsule has the same bioe-quiavailability with telmisartan tablet.

Animals ; Arrhythmias, Cardiac ; Humans ; KATP Channels ; Mitochondria ; Myocardial Ischemia

Antithyroid drugs(ATD)is the main treatment for hyperthyroidism and its adverse reactions have been much concerned by physicians. Methimazole(MMI)and propylthiouracil(PTU)are the two common antitithyroid drugs used currently. Generally, the ATD are safe and effective, though their clinical adverse reactions are also relatively common. The toxic effects include liver damage and leukocytopenia, antineutrophil cytoplasmic antibody-associated pulmonary small-vessel vasculitis, hypoglycemia, allergic reactions, muscle impairment,and so on. They are usually reversible and disappear spontaneously when the drug is discontinued. However,the serious rare side effects can also occur and there may have potentially deadly threatening effects which need to be cautious for the clinicians. MMI is usually preferred over PTU because it has significantly fewer side effects. And unlike the dose-dependent side effects of MMI, there has no significant correlation between adverse reaction and drug dosage in using PTU. Moreover, PTU has more severe hepatotoxity than MMI, even fatal liver impairment and liver failure. The risk of liver damage from PTU is an important concern, particularly in children. For this reason, MMI is the first choice for treating children with hyperthyroidism.

Objective Comparison of the modified Weaver-Dunn method with AO clavicular hook plate for acromioclavicular joint dislocation efficacy.Methods Surgical treatment of Rockwood Ⅲ to the V Type acromioelavicular joint dislocation 35 cases,depending on the surgical approach,were divided into 2 groups of the modified Weaver-Dunn method and AO clavicular hook plate.Operation time,blood loss,hospitalization costs,postoperative Xray film results,the clinical efficacy results and complications were compared between two groups.Results Modified Weaver-Dunn method Section of the longer operative time,mean intraoperative blood loss more.Shoulder pain,the incidence of postoperative modified Weaver-Dunn method group is significantly lower than the AO clavicular hook plate group,abduction activity was better than AO clavicular hook plate group.AO clavicular hook plate group prone to shoulder mobility and shoulder pain.Postoperative Karlsson assessment standard,modified Weaver-Dunn method were excellent in 10,good in 4 cases and poor in 1,excellent rate was 93％ ;AO clavicular hook plate group were excellent in 8 cases,good in 7 cases and poor in 5 cases,excellent rate of 75 ％.Conclusion Modified Weaver-Dunn method is used to treat complete acromioclavicular joint dislocation.Postoperative shoulder pain and shoulder mobility are in low incidence of shoulder function recovery effect.

Solid phase microextraction(SPME) can be effectively used to extract volatile and semivoltaile organic compounds from different environmental matrix. In this paper, we utilize headspace-SPME technique combined with capillary gas chromatography (CGC) and a laboratory modified flame photometric detector using quartz surfaceinduced luminescence (QSIL-FPD) for analyzing butyltin compounds in sediments. The detection limits of mono-,di-, and tri-butyltin compounds, based on the signal equal to 3 times the baseline noise are 16.9 ng/g, 1.58 ng/g adn 0.17 ng/g, respectively.

Objective To observe the effects of aspirin on PCNA and cyclin D1 expressions in diethylnitrosamine (DEN) induced hepatic cancer of the rat. Methods Sprague-Dawley (SD) rats were randomly divided into DEN group and DEN plus aspirin group. Each group was further divided into 8,12,16 week subgroups. The expressions of PCNA and cyclin D1 in hepatic tissue were examined with inmunohistochemistry. Results In DEN plus aspirin group cirrhosis was less severe and carcinoma developed later than that in DEN group. Hepatic carcinoma occurred in four rats out of six in DEN group at the 16th week (P<0.05). In DEN plus aspirin group PCNA and cyclin D1 expressions were significantly lower than those in DEN group(P <0.05) , inhibiting effects on cyclin D1 expression was evidently great at 16th week (F=11.944,P<0.05) and inhibiting effect on PCNA was obvious from 12th to 16th week (F=5.696 and F=11.057, P<0.05 ). Conclusion Aspirin downregulates the expressions of PCNA and cyclin D1 in hepatic tissues and inhibits the genesis and development of DEN induced hepatic cancer of the rats.

OBJECTIVE: To summarize the recent progress and clinical application of percutaneous coronary intervention and to seek the direction of new developments.METHODS: A computerized online database of Pubmed was searched to identify articles published from May 2000 to February 2009 with the key words of "drug eluting stents, peroutaneous coronary intervention, and coronary disease". There were 154 articles were retrieved by computer, by reading tities and Abstract s, 27% literatures were remained after excluding 74 irrespective papers and 53 repetitive studies.RESULTS: An ideal drug-eluting stent (DES) was comprised of a platform, a drug carrier vehicle and a pharmaceutical compound in harmony with each other. With the ongoing development of DES materials and drugs, more effective DES was introduced in the practice. Recently, clinical data on DES encourage the interventional cardiologist to use DES in more challenging coronary lesions, such as chronic total occlusions, complex lesions and multi-vessel lesions. However, the safety and efficacy of DES need further attention. Therefore, novel strategies including bioabsorbable stents, and pro-healing agents coated stents were promising.CONCLUSION: The development of percutaneous coronary intervention is a breakthrough in intervention cardiology that brings great benefit to patients with coronary disease, especially for restenosis and revascularization. Nevertheless, more endeavour will be necessary to create PCI with high efficacy as well as low risk, and safety and effectiveness of PCI in patients with ST-segment evaluation myocardial infraction and stent fracture prevention need further study.

Insulin-like growth factor-I (IGF-I) is a multifunctional cell regulating factor, which plays an important role in the normal physiological activities and pathological process, This article reviewed the research status of the molecular structure of IGF- I and its regulatory factors, the molecular biological role of IGF- I in cell proliferation, cell motility, apoptosis, and reviewed the important role of IGF-I in head and neck tumor, as well as put forward the prospects of IGF-I in middle ear cholesteatoma pathogenesis.
Apoptosis ; Cell Movement ; Cell Proliferation ; Head and Neck Neoplasms ; metabolism ; pathology ; Humans ; Insulin-Like Growth Factor I ; metabolism

Signal transducer and activator of transcription 3 (STAT3) is an important member of the STAT family of signaling pro-teins. STAT3 is widely expressed in different types of cells and tissues and is involved in many physiological and pathological process-es, including cell growth, proliferation, apoptosis, and malignant transformation. Over recent years, increased attention has been given on the role of STAT3 in tumor angiogenesis and radiation sensitivity. Studies show that on the one hand, following activation, STAT3 promotes angiogenesis by directly regulating the expression of vascular endothelial growth factor and then causes radiation resistance. On the other hand, STAT3 indirectly promotes angiogenesis by activating hypoxia-inducible factor-1α(HIF-1α), thus producing radio-therapy tolerance. Moreover, STAT3 can directly or by HIF-1αindirectly regulate CyclinD1 expression, thus rapidly promoting cell pro-gression through G1 into the S phase of the cell cycle and enhancing cell proliferation. In addition to regulating the cell cycle, CyclinD1 plays a key role in radiation sensitivity. Results suggest that STAT3 plays a role in tumor angiogenesis and radiation resistance via di-rect and indirect mechanisms. In this review, we summarize recent research advances on the role of STAT3 in regulating tumor angio-genesis and radiation sensitivity.

Objective To investigate the effect of povidone iodine irrigation combined with levofloxacin eye drops on the inflammatory indexes, NO and antioxidant indices in serum and tear fluid of patients with diabetic cataract.Methods 50 cases of pati ents with diabetic cataract and admitted into the hospital during January 2013 to January 2015 were selected as the research objects all of whom received cataract surgery.According to the randomized double blind method, the patients were divided into two groups with 20 cases in each group.The control group received levofloxacin eye drops intervention before surgery while the observation group were treated withpovidone iodine irrigation, based on the control group.The inflammatory indexes (IL-2, sIL-2R, IL-6), NO, antioxidant indexes (TAC, SOD, CAT) and condition of postoperative infection were compared between the two groups before and after irrigation.ResuIts In the observation group, the sIL-2R, IL-6 and NO levels in serum and tear fluid after irrigation were significantly lower than those in the control group while IL-2, TAC, SOD and CAT were significantly higher than those in the control group.The differences were statistically significant (P<0.05).The postoperative infection rate of the observation group was 0.0% which was significantly lower than 16.0% of the control group.The difference was statistically significant ( P<0.05 ) .ConcIusion Povidone iodine irrigation combined with levofloxacin eye drops can significantly reduce the inflammatory reactions in patients with diabetic cataract and improve their antioxidant level.