Objective To study the clinical effects of sequential therapy and standard triple therapy for Helicobacter pylori.Methods 120 cases with positive Helicobacter pylori were divided into A group and B group according to the number table method,60 cases in each group.A group received sequential therapy ( omeprazole+amoxicillin treatment after 5 days continue to omeprazole clarithromycin and metronidazole treatment for 5 days),B group received standard triple therapy ( omeprazole +amoxicillin +clarithromycin ) , eradication rate of Helicobacter pylori,the total efficiency of ulcer healing and adverse reaction of the two groups were compared.Results The eradication rate of Helicobacter pylori of group A was 91.7%(55/60),which was significantly higher than 71.7%(43/60) of group B (χ2 =11.915,P=0.023);the ulcer healing and the total effective rate of group A was 96.7%(58/60),which was significantly higher than 88.3%(53/60) of group B,the difference was statistically significant (χ2 =9.915,P=0.038);there was no statistically significant difference between the two groups in adverse reaction (χ2 =4.735,P=0.072).Conclusion Sequential therapy has a better effect in treatment Helicobacter pylori than the standard triple therapy, which can significantly improve the eradication of Helicobacter pylori, with no serious adverse reactions.

Objective To explore the etiology,pathogenesis,diagnosis and treatment of functional evacuation disorder in gastric stump after subtotal gastrectomy. Methods 15 cases with functional evacuation disorder after sub-total gastrectomy were analyzed retrospectively. Results All 15 cases were recovered by conservational therapy. Con-dusion Functional delayed gastric emptying after subtotal gastrectomy is a functional disease and can be healed with comprehensive conservation therapy at all.

Objective To explore the prevalence and risk factors of rheumatoid arthritis in the elderly population in Luohe District of Henan Province.Methods A total of 8 610 residents were recruited for a two-stage cluster sampling survey through a questionnaire of RA according to 2010 ACR/EULAR classification criteria.Physical examinations and blood tests were performed.Results The crude prevalence rate of rheumatoid arthritis was 0.76％ and 0.71％ for standardized prevalence in the middle-aged and elderly population in Luohe city.In the age distribution,of the 65-69 years old and 60-64 years old prevalence were 1.13％ and 0.84 ％,and 1.10 ％ and 0.77 ％ for standardized prevalence respectively.Sexual comparisons showed a significantly higher prevalence in females than in males (1.02 ％ vs.0.39 ％,x2 =10.513,P =0.001).The risk factors of RA were:sex (female),living floor (first floor),smoking and genetic factors,risk were 2.595 (95％CI:1.407-4.784),2.967 (95％CI:1.749-6.307) 1.682 (95％ CI:1.206-4.039) and 1.934 (95 ％ CI:1.286-4.130).Conclusion The prevalence of rheumatoid arthritis was 0.71％ in the middle-aged and elderly population in Luohe city.The risk factors involve women,smoking and hereditary factors

Measurement of IgG subclass productions, activities of interleukin-6 (IL-6) and B cell differentia- tion faotors (BCDFs) in vitro were carried out on 37 children with IgG subclass deficiency. The frequency of defective IgG subclass productions induced by PWM is in order asfollows: IgG (7/9), IgG4 (6/11), IgGl (9/17) and IgG3 (2/13). Decreased CD4 oells from PBL, low leves of lymphocyte proliferative responses to PHA and SAC, and reduced activities of IL-6 and BCDFs were found in IgG subclass deficiency patinets. 12 out of 15 cases who had decreased IgG subclass production associated with a reduced activities of IL-6 or/and BCDFs; only 4 out of 15 cases who had normal amounts of IgG subclass production associated with such lymphokine defects. The results would suggest that IgG subclass deficiency may be related to the aberration of isotype switch in order along Ig heavy chain constant gene from 5' -3', and that a variety of abnormalities in T and B cell functions share the contribution to the pathogenesis of IgG subclass deficiency, in which T cell dysfunction may play a more important role.

Pancreatic cancer (PC) is a common digestive tract tumor with high-degree malignancy,high mortality,and difficulty in diagnosis and treatment.Currently,comprehensive therapy becomes the standard and trend of tumor treatment.The treatment of PC has been developed from operation to the comprehensive therapy,including a variety of therapeutic methods.The progress of comprehensive treatment in PC was reviewed in this article.

Objective To investigate the common pathogens of endophthalmitis and their drug sensitivity .Methods 184 patients with endophthalmitis were selected .The aqueous humor or vitreous body was taken to inoculate in broth ,blood agar and potato dex‐trose agar medium for conducting bacterial and fungal culture .The K‐B method was adopted to conduct the drug sensitivity test .Re‐sults Among 184 cases ,9 cases were the mixed infection and 193 strains of bacteria were co‐cultured .Among them ,gram‐positive bacteria infection was most common ,108 strains were detected ,accounting for 55 .96% ,followed by gram‐negative bacteria ,63 strains were detected ,accounting for 32 .64% ,the detected fungi were less (22 strains) ,accounting for 11 .40% .The cultured gram‐positive bacteria were most sensitive to cefoperazone and cefuroxime both with the sensitivity of 87 .96% ,at the same time ,levo‐floxacin and cefazolin showed good sensitivity ,with the sensitivity of over 75% ,while the sensitivity to lomefloxacin was low ,only 50 .00% .Gram‐negative bacteria had highest sensitivity to lomefloxacin ,reaching 100 .00% ,in addition the sensitivity to ciprofloxa‐cin and ofloxacin also reached 87 .30% and 88 .89% ,while the sensitivity to cefuroxime ,ceftazidime and cefazolin was lower ,which were only 38 .10% ,39 .68% and 44 .44% respectively .Conclusion The infection types of pathogens should be comprehensively considered according to the causes of endophthalmitis occurrence .The combined medication should be selected during the empiric medication process after suffering from endophthalmitis .

0.05); there was a significant difference between the groups, in which the thickness of tumor was less than 5 mm, and the other one, in which the thickness was greater than 5 mm (P

0.05), but they were higher than that at day 35(P

Objective: To assess and analyze the operation efficiency of 8 commission general public hospitals managed directly by National Health and Family Planning Commission and 8 municipal general hospitals managed directly by Beijing Municipal Administration of Hospitals in Beijing and to provide suggestions on improving service capacity and designing relevant health policy.Methods: Input and output data of 8 commission hospitals and 8 municipal hospitals were obtained from Beijing Direct-Reported Health Statistics data from 2011 to 2014.Data envelopment analysis was used as the hospital operation efficiency measurement tool.The CCR and BCC models were built to calculate technical efficiency (TE), pure technical efficiency (PTE), scale efficiency (SE) and the status of scale efficiency of 16 hospitals in 2011 and 2014;the Malmquist index model was built to analyze the total factor productivity change (TFPC), technological change (TC), technical efficiency change, pure technical efficiency change and scale efficiency change of the 16 hospitals from 2011 to 2014.Results: In 2011, the TE, PTE and SE of the commission hospitals were higher than those of the municipal hospitals, and the TEs of the commission hospitals and the municipal hospitals were 0.918 and 0.873 respectively.In 2014, the TE, PTE and SE of commission hospitals were lower than those of the municipal hospitals, and the TE of the commission hospitals and the municipal hospitals were 0.906 and 0.951, respectively, which was contrary to the results in 2011.According to the Malmquist index model, the average of TFPC of the municipal hospitals was larger than that of the commission hospitals, the former increased 5.9% and the latter increased 2.8% per year;the average of TC was greater than the one in both the municipal hospitals and the commission hospitals, with a growth of 3.2% and 2.9% per year, respectively;the average growth of PTE in the commission hospitals was lower than that of the municipal hospitals, and the average descent of SE in the commission hospitals was larger than that in the municipal hospitals.Conclusion: There are significant differences in the operation efficiency between different management systems and the main factors associated with operation efficiency are the technological and management level.Given scale efficiency status and macroeconomic medical policies, the commission hospitals and the municipal hospitals require further adjusting the distribution of medical resources, and it is of great significance for all the commission hospitals and the municipal hospitals to improve the management level and resource integration capability.

Small ubiquitin-like modifiers(SUMO) are ubiquitin-related proteins that can be covalently conjugated to cellular target proteins.Frequently,this modification has a key role in regulating the activities of those targets and,hence,their cellular functions.Researches show that some oncoproteins,tumor suppressors,DNA repair proteins and cyclins are target proteins of SUMO modification and the altered expression of some enzymes related to SUMO conjugation occurs in some neoplasm.It is indicated that sumoylation is important in tumor origination,development and metastasis.