This article discusses on the natural compounds from the ant plant (Myrmecodia species, family: Rubiaceae). The ethyl acetate (EtOAc) extract from the tuber of M. platytyrea was fractionated by using medium pressure liquid chromatography, giving eight fractions (F1-F8). Those fractions were evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. Fraction F5 was recorded as potent (EC50 = 21.57 ± 1.40 µg/mL). Then, it was purified by using column chromatography (CC) (mobile phase = chloroform: EtOAc). From the CC, ten fractions (F5F1-F5F10) were obtained and compound (1) was isolated from F5F3 via preparative thin layer chromatography (TLC). After spraying with anisaldehyde-sulphuric reagent, compound (1) gave a green TLC spot (Rf = 0.65, 100% CHCl3 , multiple development). The 1 H-Nuclear Magnetic Resonance (NMR) spectroscopy (500 MHz, CDCl3 ) was performed to determine the chemical framework of (1). This compound was identified as morindolide, having an iridoid structure. Meanwhile, the mass spectra for compounds (2) and (3) were analysed. The data presented the molecular ion at m/z 375 [M-H]- and 255, suggesting the formulation of 2-(2-methylbutyryl)phloroglucinol glucoside and a flavanone, respectively. From the literature, compound (1) was firstly isolated from a Chinese natural medicine, the dried root of Morinda officinalis (family: Rubiaceae). The flavonoids are also included as the biologically active compounds from Myrmecodia. In short, this is the first occurrence of morindolide from the ant plant.
Flavonoids

Flavonoid is one of interested compounds in treatment for cancers. The authors extracts flavonoid from the leaves Houttuynia cordata and tested on S-180 cancer cells that they cultured vitro in mice. This product has effects by inhibited the growth of ascite cancer. However, the studies on large mice models are needed to survey their survival, mortality as well as clinical course, biochemical, pathology, and side effects. Flavonoid has cytotoxic activity on S-180, and maintain excessive cytotoxic on that cells
Neoplasms ; Flavonoids ; Houttuynia ; Flavonoids

A flavonoid preparation was extracted from TanCuong tea leaves and was studied on the cultured cancer cells and on the thigh tumor in mice. Flavonoids from T©n C­¬ng tea leaves (FTC) exhibited anticarcinogenic activity in vitro. FTC inhibited the reproduction of Hep-2 (human' carcinoma cell); Sp-2/O (cancer cells from mouse bone marrow) and S180 (Sarcoma cell). The most activity is on S180. In vivo, the experiments have been done in white mice BA/bc showed that FTC inhibited tumor promotion in mice. In addition, FTC decreased the metastasis of S180 into liver and lung of mice.
neoplasms ; Flavonoids

Studying the influence of temperature to the content of flavonoids in Flos Sophorae showed that the dried temperature make the significant changes the content of rutin and quercetin in Flos Sophorae. The rutin content increased when drying over a fire at 80oC-120oC, quercetin did not be changed much; at 140oC-180oC, the contents of rutin decreased slightly, quercetin increased slightly. At 200oC-220oC, the contents of rutin decreased clearly, quercetin increased clearly. These results can be applied for the standardization of Flos Sophorae using roasting methods for traditional medicines
Flavonoids ; Temperature

Study on lymphocyte culture technique of 20 peripheral blood sample, which were taken from adults nerve exposed with radiation and toxic chemical. The result showed that The chromosome aberration were caused by dose of 20rad. When radiation effect at the hour of 68 can cause chromosomal aberrations especially in chromatic aberrations. Flavonoid can reduce chromosomal aberration but it wasn't significant.
Chromosome Aberrations ; Flavonoids

The antibacterial effects of flavonoid substances isolated from plants belonging to C.clerodendron species were studied. They are included Clerodendron fragrant, C.informatum, C.cytophyllum. The results showed that flavonoids from these plants presented antibacterial activities on both strain of Gram (+) and Gram(-) but stronger effect obtained with Gram(+). The antifungal activity was week or not resulted for all these three plants. The mixed flavonoid solutions may give better antibacterial effects depending on the combination of extracted flavonoid solutions.
Flavonoids ; Verbenaceae ; Pharmaceutical Preparations

The bioactivity of flavonoid from H. sabdariffa growing in Vietnam have been investigated (signed by FHS). FHS have different effect on the inhibition of the growth and development of bacteria and fungus. Their good effects on the peroxydase activity in human blood and their liver protection from destroy by CCl4 has been expressed the antioxidant potency. On the basic of this antioxidant activity of flavonoid, the investigation of flavonoids effects on cancer cell sarcoma-180 have been realized and show that FHS could inhibit the mitosis of cancer cells. The in vivo tests have been realized on experimental animals. An optimal dose to reach the efficiency was determined (in vitro and in vivo). This result opened a perspective to apply the flavonoids of H. sabdariffa for anticancer therapy, chiefly for pre-cancer period.
Flavonoids ; Plants, Medicinal

One bioactive flavonoid on brine shrimp test was isolated from leaves of Macaranga triloba (Blume) Muell-aRG...Its structure was elucidated based on spectral analysis, including UV, FT-IR, 1H-NMR, 13C-NMR, 13C-DEPT, and was determined as vitexin
Flavonoids ; Plant Leaves

The contents of polyphenol and flavonoid from leaves and fruits of tree Momordica charantia are higher than other medicinal plants. These components are very soluble in low acid medium and ethanol. In growth processing of tree Monordica charantia, the content of polyphenol and flavonoid increase in fruits and leaves, and after then it decrease little
Flavonoids ; polyphenols ; Momordica charantia

This study demonstrated that in vitro, flavonoids from Oroxylum indicum stimulated the hydrolyzing reaction of alpha-chymotrypsin on casein. The stimulative level was dependent on time exposure and concentration of the flavonoids. In vivo, Oroxylum indicum's flavonoids had anti-inflammatory effects in dextran-induced oedema of mouse paw. When Oroxylum indicum's flavonoids were combined with alpha-chymotrypsin, their anti-inflammatory activity was increased. The successful combination between flavonoids from Oroxylum indicum and alpha - CT contributed to study anti-inflammatory effect of flavonoid and alpha - CT. It may be necessary to further study on traditional and modern anti-inflammatory medication in combination with anti-inflammatory enzyme
Flavonoids ; Inflammation ; Pharmaceutical Preparations