In China, cooking oil fume is a kind of indoor air pollutant that is ubiquitous. With the development of catering trade, the pollution of cooking oil fume is becoming more and more severe. The results of animal experiments showed that cooking oil fume could damage the genetic substance and cause cancer. The results from the epidemiological studies indicated that cooking oil fume could induce lipid peroxidation and change the pulmonary and immunologic functions, cause chromosome damage and increase the risk of lung cancer.

The academic origin and characteristics of medical families of acupuncture-moxibustion in northern Zhejiang Province were explored in this paper. With acupuncture-moxibustion characteristic of medical families in northern Zhejiang Province such as the LING (see text), the YAN (see text), the SHI (see text) and the SHENG (see text) analyzed and arranged, it was found out that taking the Internal Canon of Medicine as theory basis, their academic thoughts comprehensively absorbed acupuncture-moxibustion theories in all ages, and they continuously made innovations through constant practices, resulting in academic thoughts that focusing on application of acupuncture-moxibustion in clinic, using moxibustion for deficient illness and adopting acupuncture-moxibustion and Chinese herbs for severe and acute patients. The academic thoughts of medical families of acupuncture and moxibustion in northern Zhejiang Province are featured by unique acupoint selection and ma nipulation, thorough moxibustion methods and combined application of Chinese herbs and acupuncture-moxibustion, which is a clinical system of diagnosis and treatment with typical Jiangnan features.
Acupuncture ; education ; history ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Moxibustion ; history

Objective To optimize the technology of extracting Paeoniflorin and Puerarin from Tongqing Granules. Methods The experiment used the orthogonal experimental design (4 factors and 3 levels) with the shift-rate of Paeoniflorin and Puerarin as experimental criterion in screening the factors affecting the technology of extracting Tongqing Granules. Results All the 3 factors designed in the orthogonal experiment non-signifantly affected the extracting technology. In consideration of the industrial practice, the best condition of extracting the constituents from Tongqing Granules was decided:water extraction for 3 times, extracting with 12 fold water for 1 hours for the first time, with 5 fold water for 0.5 hours for the second time, and with 5 fold water for 0.5 hour for the third time. Conclusion The condition is the optimized technology of extracting Paeoniflorin and Puerarin from Tongqing Granules.

Objective To investigate the relationship between the changes of blood coagulation index before and after neoadjuvant chemotherapy and the chemotherapeutic efficacy in patients with breast cancer.Methods Ninety patients with breast cancer were selected,and detected the changes of blood coagulation index before and after neoadjuvant chemotherapy (TAC regimen),and the relationship between blood coagulation index and the chemotherapeutic efficacy were analyzed.Results The levels of fibrinogen (Fib),platelet count (PLT) after chemotherapy were significantly higher than those before chemotherapy [(3.42 ±0.50) g/L vs.(2.44 ±0.46) g/L,(267.83 ±61.34) × 109/L vs.(174.18 ±48.65) × 109/L] (P ＜ 0.01),D-dimer (D-D) was significantly lower than that before chemotherapy [(176.32 ± 101.41) mg/L vs.(214.55 ± 106.34) mg/L] (P ＜ 0.01).The remaining indicators before and after chemotherapy had no significant differences (P ＞ 0.05).The level of D-D in 68 cases was reduced after chemotherapy,the effective chemotherapy in 53 cases (77.9％,53/68),ineffective in 15 cases (22.1％,15/68);the level of D-D in 22 cases was increased after chemotherapy,the effective chemotherapy in 9 cases (40.9％,9/22),ineffective in 13 cases (59.1％,13/22),the difference was statistically significant (P=0.000).The level of PLT in 10 cases was reduced after chemotherapy,the effective chemotherapy in 3 cases(3/10),ineffective in 7 cases (7/10);the level of PLT in 80 cases was increased after chemotherapy,the effective chemotherapy in 59 cases (73.8％,59/80),ineffective in 21 cases (26.3％,21/80),the difference was statistically significant (P=0.044).Conclusions The Fib and PLT increase while the D-D decreases after chemotherapy,so it is necessary to monitor Fib,PLT,D-D level during chemotherapy.The D-D and PLT are effective indexes in evaluating curative effect of neoadjuvant chemotherapy in patients with breast cancer.

When the central nervous system is stimulated, the opioid neuropeptide?-endorphine (?-EP) is liberated into the blood stream. The result of this work showedthat the antigen-presenting capability (APCP) of normal human monocytes (Mon) wasmarkedly enhanced (P0. 05), sug-gesting that the effect of ?-EP was mediated through the opioid receptors on the Mon.

[Objective] To evaluate and describe CT findings in patients with pathologically confirmed retroperitoneal fibrosis. [Methods] CT findings in 8 patients (6 males, 2 females) pathologically confirmed retroperitoneal fibrosis were retrospectively reviewed and pertinent literature was discussed. [Results] Retroperitoneal fibrosis showed similar features in CT imaging: retroperitoneal irregular mass around abdominal aorta embedding adjacent tissue, with mild or moderate enhancement, unilateral or bibateral ureterectasis with hydronephrosis. [Conclusions] The pristine clinical manifestation of retroperitoneal fibrosis is occult and nonspecific. CT examination is a valuable approach to diagnose retroperitoneal fibrosis.

Objective:To compare the clinical and imaging characteristics between central nervous system vasculitis(CNSV)and mitochondrial encephalomyopathy(ME),so as to analyze the differential diagnosis of the two disorders.Methods:Clinical data on seven patients with CNSV and five with ME were retrospectively analyzed.The clinical manifestations,laboratory parameters,imaging features and histological characteristics were compared to screen for the evidence of their differential diagnosis.Results:The MRI results of both CNSV patients and ME patients(MELAS type)showed a multi-lesion pattern.The symptoms of CNSV patients included headache,limbs weakness,and erythrocyte sedimentation rate(ESR)increase.The symptoms of MELAS patients included epilepsy and increased serum lactic acid.The electroencephalographic manifestations of both diseases were abnormal:CNSV patients mainly had diffused lesions accompanied with limited alterations;ME patients had evidence of epileptic discharge,which was consistent with the clinical symptoms.Conclusion:Clinical manifestations of CNSV and ME patients are more valuable than imaging findings in the diagnosis of the two diseases.CNSV is characterized by vascular disorders and inflammatory reactions;ME is characterized by abnormal energy metabolism and severe damage of gray matter.The final diagnosis should depend on laboratory and histological examinations.

To search the statistical approaches for evaluating and dealing with the center effects in multi-center clinical trial. Breslow-Day test was used for evaluating the differences of the virtual rating among the centers whose responses were binary, Cochran-Mantel-Haenszel test for dealing with the center effects whose responses were binary or ordinal, and logistic regression for evaluating and dealing with the center effects simultaneously. The results showed that Breslow-Day test is invalid in evaluating the center effects whose response is ordinal, and Cochran-Mantel- Haenszel test can not be used for dealing with the effects of other covariates meanwhile.

Aim To observe the c-fos expression in the caudate-putman of 6-OHDA-lesioned rats after Apomorphine intraperitoneal injection and to investigate the inherent mechanism of it. Methods Rats received a unilateral injection of 6-OHDA into SNc. The abnormal rotations induced by Apomorphine (APO) were investigated 1、7、14 d and 21 d after lesion.Meanwhile dopaminergic derogation and c-fos expression were observed with Nissl body staining,eletronicmicroscopic and immunocytochemistry methods. Results The number of dopaminergic neurons decreased gradually in the lesioned site and its eletronicmicroscopic structure was damaged. When over 80% dopaminergic neurons were lossed , contralateral rotations surpassed 7 r?min~(1) and c-fos expressed in the ipsilateral striatum. Conclusion APO induces c-fos expression in the ipsilateral striatum. Intrinsic relations may exist between dopaminergic neurons deletion and c-fos expression

0.01), but the significant difference was found respectively between group C and B and between group C and A (P