By retrieval and analysis of literature, the origin and connotation of the word Bentai were stated. In the early twentieth century, one Japanese scholar introduced the word into acupuncture-moxibustion. It was mostly used to explore the mechanism of acupuncture-moxibustion and acupoints through scientific research. One Chinese scholar introduced the connotation into acupuncture and moxibustion in 1940, and it was mainly expressed the essence. Professor ZHU Bing systematically discussed Bentai of acupoints from a scientific point of view. The knowledge of acupoints, however, is diverse, and there is different cognition due to multiple perspectives. Acupoints may not have unique Bentai.
Acupuncture Points ; Acupuncture Therapy ; history ; History, 20th Century ; History, 21st Century ; Humans ; Moxibustion ; history ; Terminology as Topic

Objective:To study the inhibition of survivin expression by small interference RNA(siRNA) synthesized in vitro in renal cancer cell line 786-O. Methods:Three groups of survivin siRNAs were chemically synthesized in vitro and then transfected into cell line 786-O. The expression of survivin mRNA and protein after transfection were detected by reverse transcription polymerase chain reaction(RT-PCR)and Western Blotting. The proliferation of cells was detected by MTT. Results:Two sequence specific siRNAs targeting survivin down-regulated the expression of survivn mRNA and protein. The proliferation of cells was inhibited after transfection. The third one was ineffective. Conclusion:Sequence specific siRNA targeting survivin can efficiently inhibit the survivin expression and cell proliferation in renal cancer cell line 786-O. The successful application of RNAi targeting survivin might extend the list of available gene therapeutic modalities in renal cancer.

Biomarkers ; Cystatin C ; blood ; Early Diagnosis ; Hepatorenal Syndrome ; diagnosis ; Humans ; Renal Artery

AIM: To evaluate and analyze the morphological property and physiological activity of cartilaginous loose bodies in the knee joint, to research the changeable mechanism of histological morphous and physiological function. METHODS: The experiment was conducted at the Department of Pathology of the First Affiliated Hospital of Anhui Medical University, the Physical Testing & Chemical Analysis Center of Anhui Medical University, and the Electron Microscope Center of Anhui Provincial Hospital Affiliated to Anhui Medical University from January 2005 to January 2006. ①Experimental samples were 30 cartilaginous loose bodies all through arthroscopy as experimental group in which Group A (less than 6 months) had 14 samples and group B (between 6 and 12 months) 10, group C (more than 12 months) 6. Another 30 control samples were originated from non-weight loading side of articular cartilage through special equipment by arthroscopy. ②All samples were carried out the morphological measurement, light and transmission electron microscope exam, Ⅱ-collagen immunohistochemical stain, the measurement of collagen, calcium and fosforus. RESULTS: ①To compare the samples in the group A and control group, they had the identical or similar morphosis, microscopic structure of chondrocyte and distribution of extracellular matrix, the statistical treatments of the content of calcium, fosforus and collagen showed that the differences of scores between two groups were not statistically significant [calcium:(3.120?0.224),(3.090?0.231) mg/g;fosforus:(0.432?0.045),(0.455?0.067) mg/g;collagen:(462.43?17.12)(466.71?14.59) mg/g]. General speaking, comparing with the control articular cartilage, the loose bodies in group A had the normal histological property and physiological activity. ②Compared with control group, the samples in group B and C had the tendency of fibrous degeneration: necrotic or degenerative chondrocytes increasing, the contents of proteoglycan and Ⅱ-collagen decreasing, the tendency in group C more than group B, but the cartilaginous loose bodies in group B and C had many active chondrocytes mainly. Total content of collagen [(441.20?16.49),(417.33?8.38) mg/g] and Ⅱ-collagen decreased, while the contents of calcium and fosforus increased [calcium: (3.696?0.442),( 6.469?0.555) mg/g;fosforus:(0.523?0.068),(0.683?0.056) mg/g]. Generally, compared with the control articular cartilage, the histological property and physiological activity of the loose bodies in groups B and C had changed. CONCLUSION: The cartilaginous loose bodies can remain its histological property and physiological activity in the knee articular cavity for a long time, but it has the tendency of disorganization and physiological activity descending as time prolongs.

Mitochondrial calcium homeostasis plays a key role in maintaining various cellular characteristics and mediating cellular physiological function and pathological processes .Although it has long been known that mitochondria takes up Ca2+, the molecular identities of the channels and transporters involved in this process are revealed only recently . Here, we review the structure and function of the channel-forming subunit, mitochondrial calcium uniporter (MCU) and its regulators, which include MICU1, MICU2, and MCUR1.

Acupuncture, as one of the most distinctive traditional Chinese medicine (TCM) treatment, had a wide range of advantages in the treatment of gastrointestinal disorders with obvious clinical efficacy. The onset of functional dyspepsia had increased year by year. However, the exploration on mechanism was unclear and drug abuse showed poor clinical outcomes. Acupuncture can effectively improve gastric motility. Through a variety of ways to act on the gastrointestinal tract, gastrointestinal function was restored to improve a variety of symptoms in patients with functional dyspepsia, which provided scientific basis for the clinical selection and application of acupuncture in functional dyspepsia treatment. This paper summarized the acupuncture treatment mechanism of functional dyspepsia in recent ten years, in order to provide references for scientific basis in acupuncture treatment of functional dyspepsia. It also provided references for the development of reasonable treatment options in the clinical practice.

In recent years,the research of pomegranate seed oil has developed and deepened, which mainly includes the study of pomegranate seed oil anti-inflammatory,antidiabetic,anti-tumor and anti-oxidation and so on.This paper has reviewed the mechanisms of its anti-inflammatory and antidiabetic functions in order to facilitate the pomegranate seed oil a better exploitation and analyzes its applicable prospects .

Objective To explore the cognition impairment of Parkinson's disease (PD) subtypes and the risk factors for cognitive dysfunction.Methods Totally56 patients with PD and 30 control subjects were selected.All patients were assessed by Mini-Mental State Examination (MMSE),the Montreal cognitive assessment scale (MoCA),digital span test scale (DS),block design test scale (BD).The cognition impairment status of PD subtype was compared between the two groups.Risk factors for cognitive impairment in Parkinson's disease were analyzed by the multiple regression analysis.Results The scores (or accuracy) of visuospatial / executive function,memory,repeat,attention,animal naming,understanding,calculation,orientation in PD patients and control group were (29.84±13.78) and (44.63±10.95),(17.64±3.00) and (21.93±2.12),(1.64±0.90) and (2.40±0.62),64.29％ and 86.67％,(2.25±0.77) and (2.70±0.47),(2.66± 0.67) and (2.93±0.25),(3.98±1.17) and (4.93±0.25),(9.59±0.68) and (9.93±0.25) respectively,and there were statistically significant differences in above indictors between two groups (t=-5.080,-7.707,-4.571,-3.374,-2.710,-5.844,-3.367,respectively,x2 =4.86,all P＜0.05).Pearson correlation analysis showed that the cognitive function had a positive correlation with education status,had negative correlations with duration of disease,Unified Parkinson's Disease Rating Scale (UPDRS)-Ⅲ,Hoehn and Yahr (H-Y) staging,Hamilton Anxiety Scale (HAMA),Hamilton Rating Scale for Depression (HRSD) (MMSE:r=0.488,-0.682,-0.478,-0.465,-0.611,-0.538,respectively,all P＜0.05,MoCA:r=0.553,-0.583,-0.396,-0.384,0.499,-0.444,respectively,all P＜0.05),and had no correlation with gender,age,age of onset.Taking the duration of disease,education status,UPDRS-Ⅲ,H-Y grade,HAMA,HRSD as the independent variable,MMSE,MoCA as the dependent variable,multiple linear regression analysis showed that only the duration of disease and education status had effects on cognitive dysfunction in PD (MMSE:β=-0.042,0.196,both P=0.000,MoCA:β=-0.052,0.367,both P＜0.05).Conclusions The key points of cognition impairment in PD patients are the impairments in visuospatial/ executive function,memory,repeat,attention,animal naming,understanding,calculation and orientation.The duration of disease and low level of education are the risk factors for cognitive dysfunction in patients with Parkinson's disease.

Objective To investigate the relationship between primary hepatocellular carcinoma (HCC) with multiple nodules and short-term recurrence after radical resection.Methods We retrospectively analyzed the clinical data and follow-up of 692 consecutive HCC patients who underwent curative resection at the Affiliated Hospital of Qingdao University from January 2000 to December 2011.The diagnosis of multiple nodules was based on preoperative imaging data and observations in operation.Results Of 692 HCC patients, 126 patients had multiple nodules (18.2％, the MN group) and 566 patients had a single nodule (71.8％, the SN group).The 1-, 2-, 5-, and 10-year overall survival (OS) rates were 86.5％,72.2％, 38.1％, and 23.2％ for the MN group, and 93.8％, 82.7％, 58.2％, and 35.7％ for the SN group, respectively (P ＜ 0.05).The 1-, 2-, 5-, and 10-year disease-free survival (DFS) rates were 68.6％, 46.8％, 27.2％, and 19.8％ for the MN group, and 80.2％, 62.1％, 42.0％, and 34.6％ for the SN group, respectively (P ＜ 0.05).Cox regression model analysis showed a maximum nodule diameter of ＞ 5 cm was an independent risk factor of short-term recurrence in the MN group.Conclusions The prognosis of HCC patients with multiple nodules after radical resection was poorer and the short-term recurrence rate was significantly higher than those patients with a single-nodule.A maximum nodal diameter of ＞ 5 cm was an independent risk factor of short-term recurrence for patients with multiple nodules after radical resection.Therefore, patients with multiple nodules, especially ＞ 5 cm, should be followed up closely and they are good candidates for a multiple disciplinary team (MDT) treatment.

Lycobetaine ( AT-1840 ) is an effective antitumor substance. In the present work it was demonstrated that in a dose of 40 pig/kg AT-1840 could decrease the percentage of G, cells, meanwhile it increased G2 + M cells remarkably by means of flow fluocytometry method, AT-1840 could also inhibit the progression of cells from G2 to G1 phase. 8 to 72 h after, the injection the mitotic index was decreased significantly and recovered gradually in 6 d. It could inhibit the prophase and metaphase greatly, but had no marked influence on anaphase & telophase.