The individual and multidisciplinary treatment is decided by the complexities of befalling-mechanism and clinical symbolization in hemiplegia resulting from stroke. So we enactmented the multidisciplinary treatment protocol, which includes traditional Chinese medical differentiation treatment, acupuncture and rehabilitation-treatment-technique by stages. The result of clinical treatment showed that the multidisciplinary treatment protocol is suitable to living qualities of hemiplegia and embodies the superiority of unity and individual integrated.

Objective To investigate the clinical effect of labetalol in treatment of pregnancy hypertension and the influence on the outcome of delivery.Methods 110 patients with pregnancy hypertension from July 2013 to July 2015 in Boai Hospital were selected as the research subjects,and they were randomly divided into observation group and control group,55 cases in each group.The control group was treated with conventional treatment,while the observation group was given labetalol on the basis of the control group.The clinical curative effect,birth outcomes were compared between the two groups.Results (1)After treatment,the diastolic blood pressure and systolic pressure in the observation group were (67.95 ±4.87)mmHg and (134.62 ±11.82)mmHg,which were lower than pre -treat-ment,the differences were statistically significant (t =7.435,9.224,all P <0.05).Those in the control group after treatment were (91.22 ±3.52)mmHg and (151.69 ±14.68)mmHg,which were significantly lower than before treat-ment (t =4.109,5.240,all P <0.05),the differences between the two groups after treatment were statistically signif-icant (P <0.05).(2)Neonatal Apgar score of the observation group was (9.33 ±0.76)points,which was signifi-cantly higher than (7.85 ±0.85)of the control group,the difference was statistically significant(t =5.108,P <0.05).The incidence rates of cesarean section,neonatal asphyxia,fetal distress and postpartum hemorrhage of the ob-servation group were 43.64%,3.64%,5.45%,3.64%,which were significantly lower than the control group,the differences were statistically significant (χ2 =8.942,19.057,14.122,16.936,all P <0.05).Conclusion The use of labetalol in treatment of patients with hypertension of pregnancy can significantly reduce the blood pressure level and birth's score,improve maternal birth outcomes,which is worth clinical promotion.

An apparatus of true color medical photometric analysis, a quantitative pathologic technique, was adopted to measure DNA ploidy content in 51 cases with limbus epithelial neoplasm. According to the DNA pattern, the cells in the neoplasm were divided into 4 types: diploid (2C), tri-to tetraploid (3-4C), pentaploid (5C) and≥5C. In the lesion of epithelial hyperplasia, 2C-4C ceils accounted for 88.59%, and≥5C cells, 11.41%. In atypical hyperplasia, 2C-4C cells accounted for 58.62% and ≥5C cells, 41.38%. In the cases of carcinoma in situ and squamous cell carcinoma, 2C-4C cells accounted for 21.11% and 21.69%, and ≥5C cells, 78.89% and 78.31% respectively. These data were analyzed between each two groups by x~2 test (P

Objective:To establish the conformity test model for tamsulosin hydrochloride sustained-release capsules by near infrared absorption spectroscopy. Methods:Tamsulosin hydrochloride sustained release capsules were scanned within the range of 4 200-12000 cm-1 to establish the conformity test model. Results:The spectral coverage of 9 000-7 500 cm-1 , 6 900-5 600 cm-1 and 5 000-4 250 cm-1 were chosen, and the second derivative vector normalization was used to detect the samples. The CI value was 7. The conformity test model could distinguish authentic and false tamsulosin hydrochloride sustained-release capsules. Conclusion:The method is simple, sensitive, accurate and fast, and can be used in the identification of tamsulosin hydrochloride sustained-release capsules.

Adult ; Aortic Stenosis, Supravalvular ; Child ; Female ; Humans ; Mothers

AlM: To investigate the effect and value of amniotic membrane patches and grafts for acute ocular surface burn at different degrees.?METHODS: A retrospective analysis of 28 cases ( 28 eyes) affected by ocular chemical or thermal burn with different degree were included in our hospital from March 2007 to March 2012. Amniotic membrane patched was undergone in 13 eyes with fresh amnion that the patients corneal burns degree II or Ⅲ with partial limbal buns at degree Ⅳ. Amniotic membrane grafts was performed in 15 eyes with fresh amnion that the patients all corneal burns at degree Ⅲ with the whole limbal necrosis without severe eyelid defect. The follow-up time ranged 6 ~24mo. The postoperative visual acuity, the condition of amniotic membrane transplant, renovation of cornea and complications were observed.?RESULTS: Postoperative corrected visual acuity was improved in 20 eyes (71%), it was not changed in 5 eyes (18%), the visual acuity declined in 3 eyes (11%). The amniotic membrane survived in 23 eyes and the survival rate was up to 82%. The cornea of 4 eyes recovered to transparent, nebula emceed in 8 eyes eventually, corneal macula emerged in 10 eyes, 4 eyes ended up with leukoma, 2 eyes developed corneal melting after therapy, then received lamellar keratoplasty. Corneal surface become epithelization after amnion patches or grafts, but any of them have recurrent epithelial erosion, and become stable epithalization after repeat operation.?CONCLUSlON: Amniotic membrane patches and grafts is an effective method to deal with acute ocular surface burn.

Objective To discuss the application value of diffusion weighted imaging(DWI)in the diagnosis and treatment of synovial sarcoma.Methods 48 patients with synovial sarcoma were selected.All patients were given conventional magnetic resonance imaging (MRI)and DWI detection examination,DWI diffusion sensitive factor examination was 500 s/was(b).All the patients'imaging results and disease detection were analyzed.ROC curve was used to analyze the value of DWI,MRI examination in the diagnosis of synovial sarcoma.Results DWI examination detection of synovial sarcoma was much higher than that of MRI,the difference was statistically significant(χ2 =5.62, P <0.05).ROC curve analysis showed that MRI examination in the diagnosis of synovial sarcoma specificity was 72.58%,sensitivity was 79.12%,the accuracy was 86.82%,DWI examination in the diagnosis of specificity was 76.81%,sensitivity was 85.79%,the accuracy was 95.18%.The sensitivity,specificity and accuracy of DWI were significantly higher than conventional MRI,the differences were significant(χ2 =5.72,5.68,5.12,all P <0.05). Conclusion DWI can effectively improve the detection rate of synovial sarcoma,and has higher diagnostic sensitivity, specificity and accuracy,it's conducive to the physician for treatment in a timely manner,and worthy of further clinical promotion.

OBJECTIVE: To develop a UFLC-MS/MS method for the determination of simvastatin in human plasma, so as to investigate the relative bioavailability of two kinds of simvastatin tablets. METHODS: After liquid-liquid extraction by methyl tert-butyl ether, the analytes were seperated on a Shim-pack XR-ODS column with a gradient elution by the mobile phase of water (A) and aceto-nitrile (B). Conditions of the gradient elution were as follows: 0.01-3 min, B:80%-90%; 3-3.5 min, B:90%-95%, 3.51-5 min, B:80%. Multiple reaction monitor (MRM) was used to determine the concentration of simvastatin (m/z 441.2 → 325.1) and the internal standard, lovastatin (m/z 427.2 → 325.2). A single oral dose of 40 mg test or reference preparation was given to 20 healthy volunteers in a randomized crossover design. Blood samples were obtained and analyzed by the validated UFLC-MS/MS method, and the pharmacokinetics and bioavailability were evaluated by Phoenix WinNonlin 6.0 software. RESULTS: The calibration curve of simvastatin was linear over 0.1-20 ng · mL-1 (r=0.9954) with the lower limit of quantity of 0.1 ng · mL-1. The absolute recoveries were between 63.9% and 83.8%, the extraction recoveries were 63.9%-83.8%, and inter- and intra-day RSDs were less than 7.1% and 10.0%, respectively. The main pharmacokinetic parameters of simvastatin of the test and reference tablets were as follows: t1/2 were (3.96 ± 1.65) and (3.77 ± 1.75)h; ρmax were (8.3641 ±4.9898) and (8.4399 ± 4.8566) ng · mL-1; tmax were (1.71 ± 1.19) and (174 ± 1.10) h; AUC0-t were (29.74 ± 13.05) and (31.16 ± 13.92) ng · h · mL-1; AUC0-∞ were (32.35 ±14.56) and (33.39 ± 14.55)ng · h · mL-1, respectively. The relative bioavailability of the test to reference tablets was (97.3 ± 24.3)%. CONCLUSION: The two preparations are bioequivalent. The established method is successfully used for the bioequivalence study of simvastatin preparations.

Objective To describe the academic impact of publications from National Institute of Parasitic Diseases （NIPD），Chinese Center for Disease Control and Prevention，so as to give the quantity evidence for scientific research decision making. Methods The SCIE papers of NIPD published from 2011-2015 were searched and statistically analyzed. The number of published papers，citation frequencies，h⁃index，and funding resources were analyzed. The academic impact of the institute was assessed according to these data. Result A total of 361 papers were published by NIPD，and the quantity increased year by year. The majority type is original articles. The total citations were 1 641 times，the average citation per paper was 5.19 and h⁃index was 17. The majority of these papers were published in foreign professional periodicals，whose impact factors were between 1.194 and 6.751. The major resources of NIPD were from China，and NIPD also had good collaborations with institutions in US and Switzerland. In China and Asia，NIPD led the research in the field of parasitology and tropical medicine. Conclusion The quantity and quality of annual published papers of NIPD are on the rise. However，NIPD lagged behind the leading institutions in the world.

Objective To study the protective mechanism of mild hypothermia from severe traumatic brain injury (sTBI). Methods 160 cases with sTBI were treated under normothermia (NT group, n=80) and mild hypothermia (HT group, n=80) respectively. Their serum level of anti-brain antibody (ABAb) was measured with ELISA, cerebral haemodynamics with transcranial Doppler, and intracranial pressure (ICP) with ICP monitor 1 d, 3 d, 5 d, 7 d and 14 d after injury, while they were assessed with Glasgow coma scale (GCS) and Glasgow outcome scale (GOS). Results The level of ABAb was lower in HT group than in NT group (P<0.05) at every point. The scores of GCS increased (P<0.05), and the volume of systole, mean and pulse index improved more in HT group 5 d after injury (P<0.01). The ICP was lower in HT group 3 d after injury (P<0.01). The score of GOS was better in HT group than in NT group when discharged (P<0.05). Conclusion Mild hypothermia can reduce the level of serum anti-brain antibody, improve cerebral haemodynamics, decrease ICP and improve the prognosis in patients with sTBl.