BACKGROUND:With the help of computer aided analysis technique, the prediction and analysis of the surgical treatment and rehabilitation of patients with femoral necrosis, which can realize the scientific operation and recovery of the patients after surgery, is a hot research topic in the field of international related research. OBJECTIVE:By studying the force deformation and stress distribution, fracture risk, and Interface’s biomechanical properties of the femoral head in different core decompression materials, we can provide the basis for choosing the appropriate core decompression material. METHODS:Based on nuclear magnetic resonance imaging images of six patients with different ages, the three-dimensional model and finite element analysis model were established, and the physiological load and four different types of materials (Actifuse, BioOss, Osteoset, Prodense) were set up. Finite element analysis software AnsysWorkbench was used to analyze the performance of the femur. RESULTS AND CONCLUSION:The maximum stress distribution law of the femur in the work process was obtained. With the increase of the Young’s modulus of the material, the maximum normal stress of the femoral necrosis region was decreased, but the biomechanical properties of the joint surface, such as sliding distance, friction stress and pressure, are increased. On the basis of comprehensive consideration of the biomechanical properties of the fracture risk and the junction, a suitable core decompression material (Osteoset) is recommended.

Objective To explore the relationship between the sperm DNA integrity and ART result.Methods Employ improved SCD test for sperm DNA integrity assay.Meanwhile,statistical methods was used for data analysis.Results After compaed the infertility rate( IVF:77.4％ vs 84.8％,P =0.366;ICSI:90.1％ vs 92.1％,P =0.899),cleavage rate ( IVF:97.1％ vs 96.4％,P =0.958 ; ICSI:96.0％ vs 99.0％,P =0.845 ),high-quality embryo rate ( IVF:42.8％ vs 38.6％,P =0.485 ; ICSI:25.8 ％ vs 46.2％,P =0.002 ) and pregnancy outcome ( IUI:13.8％ vs 16.6％,P =1.000;IVF:35.3％ vs 73,7,P =0.150;ICSI:49.5％ vs 42.8,P =0.832) between the populations with normal and abnormal sperm DNA integrity during ART therapy,there is no statistical difference was found except high-quality embryo rate with ICSI therapy.Conclusion Sperm DNA integrity value can't be used to predict the ART outcomes independently.

Objective To explore the role of apoptosis in the pathogenesis of acute pancreatitis(AP)and to (investigate) the effect of ligustrazin(LGT) on the apoptosis in acute pancreatitis .Methods Experimental animals were divided into three groups randomly: (1) AP group, (2) comparison group,and (3) therapy group. Pathologic score and TUNEL method were used to detect the pathologic mophology of pancreatic tissue and the pancreatic cell apoptosis index in the 3 groups. Results In the early stage of AP,the majority of cells are apototic and the degree of AP is slight.In the late stage of AP,the majority of cells show necrosis,and the degree of AP is severe.The (induction) of cell apoptosis can lessen the pathologic state of AP. Conclusions The degree of pathologic changes in AP can be lessened by the induction of cell apoptosis,but there is a definte time limit.

Objective To explore the role of inflammatory mediators in the pathogenesis of acute pancreatitis(AP).Methods Observation the relationship betweent the changes in serum TNF and IL-6 and(histopathology) of the pancreas in AP rats.Results(1)Rats in sham operation group survived throughout the experiment.Compared with of sham operation group,in AP group survival time shortened significantly(P

Objective To explore the changes of plasma endotoxin and D-lactate during intestinal mucosal barrier injury of acute pancreatitis.Methods Wistar rats were randomly divided into sham-operation(SO)group,and severe acute pancreatitis(SAP)group.Plasma endotoxin and D-lactate were determined at 1,3,6 and 12 hour after operations.Results The plasma endotoxin and D-lactate in SAP group increased obviously with time,and the difference betueen the 2 groups was significante(P

Traditional Chinese medicine teaching in general medical university was unsatisfied under the influence of many problems such as indefinite purpose,few class hours but many teaching contents,the different theoretical system between traditional Chinese medicine and western medicine,and theory divorced from practice etc.Therefore,the author suggested several measures that may help increasing teaching quality such as making definite course purpose and stimulating students' learning interest,enhancing training of imagery thinking,carefully electing teaching contents,integrating theory with practice and increasing clinical practice etc.

Objective To observe the clinical effects of treating Vetigo due to Vertebrobasilar Insufficient blood supply and hyperactivity of liver-Yang with Tianzhi Granules. Methods 118 cases were randomly recruited into a treatment group with 62 cases and a control group with 56 cases. On base of routine treatment, the treatment group was treated with Tianzhi Granules orally; and the control group was treated with Duflomed Hydrochloride orally. One course of treatment was 14 days. Results The total effective rates were 96.77%and 78.57% in treatment group and control group respectively. There was a significant difference between the two groups(P<0.05). The blood flow rat(BFR)of brain was improved in both groups, but the improvement of the BFR in brain was significantly better in the treatment group than the control group (P< 0.05). No adverse reaction was found in the treatment group. Conclusion Tianzhi Granules is effective and safe in treating Vetigo due vertebrobasilar insufficient blood supply.

Adult ; Aged ; Female ; Fistula ; surgery ; Humans ; Male ; Middle Aged ; Pectoralis Muscles ; transplantation ; Pharyngeal Diseases ; surgery ; Reconstructive Surgical Procedures ; methods ; Surgical Flaps

Objective To characterize the clinical features and the prognosis of paediatric lobar pneumonia. Methods Clinical data of 45 cases with paediatric lobar pneumonia,such as clinical manifestations,symptom, pathogens and prognosis were retrospectively analyzed.Results Of the 45 patients,45 cases had cough,43 cases with fever,15 cases with pain in the chest,13 cases wtih cutaneous lesions,35 cases wtih antibody of mycoplasma positive, 6 cases wtih Staphylococcus aureus infection,21 cases wtih Streptococcus pneumonia infection,cardiovascular and digestive system were involved besides lung,secondly nervous system involved.After treatment,29 cases were cured, 15 cases improved,1 case transferred other hospital.Conclusion Paediatric lobar pneumonia caused by decreased gradually,but increased by virus and other bacteria.Cases of paediatric pneumonia with fever,cough,pulmonary symptom should be tested by laboratory finding,especially antibody and X ray or CT in order to identify pathogenesis of disease,thus to be treated correctly,dosage and course of antibiotics should be also enough.

Objective To study the primary volume of bone cement and the method of perfusion and the clinical effect of percutaneous vertebroplasty for bone metastatic tumors. Methods Percutaneous vertebroplasty was performed in 218 vertebral bodies of total 150 patients,including 92 males and 58 females with age of 26-85,averaging 56.8 y. 218 vertebral bodies included 73 dorsal vertebra and 138 lumber vertebra and 7 sacral vertebra. Operations were taken under the DSA monitoring. The approach route was selected according to the morphology of the vertebrae,damage extent and puncture site. Results Operation was successful in all 218 vertebrae of total 150 patients with a ratio of 100%. The primary volume of bone cement needed to fill dorsal vertebra was 2-5 ml,average 3.5 ml; that for lumber vertebra was 3-8 ml,average 5.5 ml; and that for sacral vertebra was 4-7,average 5.5 ml. 134 patients showed total pain relief (89.3%); 15 patients had partial remission (10%) and 1 failure (0.7%). The cement extravasated to intervertebral disk in 12 patients,to scleromeninx capsula externa in 10,to para-vertebra plexus venosus in 3 and to paravertebra soft tissue in 4. The incidence of leakage of bone cement was 13.3%,but no complications occurred during and after the operation. Concolusion Percutaneous vertebroplasty provides obvious pain relief effect for vertebral metastasis,worthy to be recommended widely in clinical application.