By the condensation of 5-fluoroisatin with various p-X-C6H4NH2 compounds, 4 derivatives (I-IV) were formed. Compounds (I-IV) underwent Mannich reaction and gave V-XII with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). All synthesized compounds hade been characterized by IR, MS and elemental analysis. All synthesized compounds (I-XII) were tested for biological activities such as antibacterial and antifungal. Among them, compound V showed an antibacterial activity on 6 strains of bacteria. Compound IX and X showed an antibacteria and antifungal activity against Candida albicans... Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound XI and XII showed an antibacterial activity on 2 strains of bacteria.
Pharmaceutical Preparations ; antibacterial agents ; antifungal agents