The sub-chronic toxicity of piperaquine phosphate was assessed in rabbits. Piperaquine phosphate (PQP), at the doses of 50 and 100 mg/kg of body weight per day for 28 consecutive days, was administered orally. The influences of PQP on rabbits' laboratory indices were observed during the PQP administration and after the treatment. Rabbits treated with PQP by oral administration were found to have normal action dinning. At the dose of 50mg/kg per day for 28 consecutive days, the body weights of rabbits was increased significantly during study period (p<0.05), but was not changed significantly at the dose of 100 mg/kg per dayx 28 days. PQP, at the dose of 50 mg/kg per day for 28 consecutive days, did not change significantly biochemical indices (SGOT,SGPT, bilirubin and protein) and some hematological indices (leukocytes, leukocyte formula and hemoglobin), but significantly increased erythrocytes and creatinine on days 14 and 28. At the treated dose 100mg/kg per dayx28days, biochemical indices (SGOT, protein) and some hematological indices (erythrocytes, leukocytes and leukocyte formula) did not change significantly during study period, but creatinine, bilirubin and SGPT were significantly changed
Animal Experimentation ; Rabbits

The BB 1O1's effects on the reproductive progress of parents (P), the first (Fl) and the second (F2) generations of mice were investigated at the National Institute of Malariology, Parasitology & Entomology (NIMPE) between February and October 2004. The mice were dosed with BB 101 50mg/kg/day for 5 consecutive days. BB 101 was found to cause no effects on birth progress, mating rate, fertilization. Early died fetuses and late died fetuses were similar among P, F1 and F2. The new born mice were found to have no innate defects. Their size and weight were normal.
Reproduction ; Animal Experimentation ; Mice

Study on the extract of Morinda citrifolia (MC) fruit with the ratio of 5:1 (1g extract was prepared from 5g of dried MC fruit) in order to determine the effects of extract on radiation-induced immunosuppressive mice. The results showed that: oral administration of this extract with daily dose of 6 g/kg in 9 consecutive days (3 days before and 6 days during receiving gamma ray) has increased the relative weight of spleen and thymus, total leukocyte count, number of lymphocytes, natural killers and monocytes, rate of immune rosette forming cells, hemolytic halo, and the skin test with OA antigen, compared with the mice group that has been only received gamma ray without drug
Morinda ; Animal Experimentation ; Radiation

Method of dissemination intravascular coagulation (DIC) was used on experimental rabbits by intravenous thrombin solution 15 IU. Then rabbits were divided into 3 groups: the control group (8 rabbits) received NaCI 0.9% solution 2 ml/kg W.b/24h; the study group (10 rabbits) received mixed pollution cracetin 10.5 mg/kg/24h; the compare drug group (10 rabbits) received Tanakan solution 4.8 mg/kg w.b. All 3 rabbits groups were orally received in one continuous week. On experimental model of DIC at the dose of 10.5 mg/kg W.b/24h orally within 7 days, cracetin elongated the values of the Howell time, Quick time, thrombin time, partial thrombin time. The drug cracetin increased amount of fibrinogen, restored the number of thrombosis that were consumed more in the progress of forming blood coagulation before.
Blood ; Animal Experimentation

The BB134's sub-chronic toxicity in rabbits was investigated at NIMPE's laboratory. BB134 was orally administered at the dose of 9mg/kg of body weight per day for 28 consecutive days. The influence of BB134 on rabbit's laboratory indices and cardiovascular system were observed during and after the BB134 administration. The BB134 had not change the normal indices of development as well as the biochemical and some hematological indices of the experimental rabbits. During the study time the rabbits acted and ate normally. The body weight was increased significantly. SGOT, SGPT, bilirubin and creatinine as well as leukocytes, leukocyte formula and hemoglobin had no change. However erythrocytes decreased significantly by day 14. BB134 was also found not to affect significantly on rabbits' cardiovascular system (rabbits' heart rhythms and cardiovascular waves such as P, QP, QRS, T and QT of the control and treated groups were not changed significantly
Malaria ; Animal Experimentation ; Artemisinins

No abstract available.
Animal Experimentation* ; Animals* ; Echocardiography*

Gamma irradiator is widely used for cell, animal experiment, irradiation for blood, dose measurement, and education. Biobeam8000 gamma irradiator (STS Steuerungstechnik &. Strahlenschutz GmbH, Braunschweig, Germany, Cs137, 81.4 TBq) that KIRAMS (Korea Institute of Radiological and Medical Science) has is a irradiation device that enables to be used in large-capacity of 7.5 L and extensive area. Cs-137 source moves range of 24 cm back-and-forth in a regular cycle in beaker for uniform irradiation and a beaker that puts a specimen like existing radiation irradiator such as Gammacell3000 rotates 360degrees during irradiation. Precise dose information according to the location of radiation source would be needed because of the movement of radiation source, whereas radiation could be uniformly irradiated in comparison with existing gamma irradiator. In this study, dose distribution of the inside beaker located in Biomeam8000 gamma irradiator was measured using glass dosimeter, and dose evaluation and distribution regarding dose linearity and dose reproducibility were implemented based on measurement results. This aims to show guideline for efficient use of irradiator based on measurement result when doing experiment or radiation exposure.
Animal Experimentation ; Germany ; Glass

Introduction on the factors influence dosage that is equivalent in effectiveness between animals. They comprised drug metabolism, minimum concentration have with effect in serum, the effective time, cellular respiration, organic weight rate comparison with body weight, heat production, cytochrom C, volume of kidney and body surface.
Dosage Forms ; Animal Experimentation

A study on the roborant effect of drug by swimming test in the experimental rat or mice was carried out. The swimming time calculated from standing swimming until rat was exhausted that can not swim. There were 2 method of calculation, including average swimming time and second swimming time comparing with the first swimming time.
Pharmaceutical Preparations ; Animal Experimentation

The study was carried out on 100 healthy rats, weight of 12020g which were divided into 10 groups. Raw materials: BB103 pure powder and mefloquine. Results: In rats received BB103 with doses of 50 mg/kg and mefloquine 50 mg/kg in 5 days, there were no significant changes on process of conditioned reflex, speed of reflex establishment was stable, response time and extinguishing time of reflex were similar to those of the control group (p>0.05). In rats received BB103 with doses of 100 mg/kg and mefloquine 100 mg/kg in 5 days, there were significant changes on speed of reflex establishment and response time (p<0.01-0.05). There were differences on speed of reflex establishment, speed of stable reflex in rats received BB103 and mefloquine (p<0.01-0.05)
Artemisinins ; Rats ; Animal Experimentation