Objective To explore the application value of laparoscopic surgery in type 2 diabetes patients with acute cholecystitis.Methods 50 type 2 diabetic patients with acute cholecystitis were chosen as the research objects,the patients were divided into the observation group and control group according to the method of treatment, 25 cases in each group.Strict control of blood glucose levels in patients before operation,the observation group treated by laparoscopy,the control group were treated with conventional open surgery.Recorded the operation time and hemor-rhage,postoperative abdominal drainage,anal exhaust time,patient ambulation time and hospitalization time and other indicators.The patients were followed up to record the postoperative infection,occurrence of complications such as postoperative inflammation.Results There was no statistically significant differences between the two groups in oper-ation time(t =1.02,P >0.05).In the observation group,the intraoperative blood loss was (41.2 ±8.3)mL,postop-erative drainage volume was (107.5 ±16.4)mL,which were significantly lower than those in the control group,and the anal exhaust time was (1.7 ±0.3)d,total hospitalization time was (7.1 ±1.7)d,which were significantly shorter than those of the control group,the differences were statistically significant(t =3.43,3.78,3.43,4.21,all P <0.05).The observation group the complications included wound infection 1 cases,the complication rate was 4.0%, while in the control group,the complications included bile leakage,reflux esophagitis,incision infection,fat liquefac-tion,pulmonary infection and incisional hernia,the overall complication rate was 24.0%,there was statistically signifi-cant difference in the complication rate between the two groups(χ2 =4.54,P <0.05).Conclusion The laparoscopic surgery in the treatment of type 2 diabetic patients with acute cholecystitis has exact effect,and the patients recovery time is short,the complication rate is low.

BACKGROUND:Salvianolic acid B is an effective monomer component of Salvia miltiorrhiza, which has been shown in recent years to have neuroprotective role and to promote nerve recovery, but its mechanism is not clear. OBJECTIVE: To explore the protective mechanism of salvianolic acid B on Schwann cels in rats with spinal cord injury. METHODS: Schwann cels of Sprague-Dawley rats were cultured and divided into normal control group, model group, 10 μmol/L methylprednisolone group and salvianolic acid B group (0.1, 1, 10, 100 μmol/L). Models of Schwann cel injury induced by lipopolysaccharide were established in al the groups except the normal control group. After intervention, growth curve and proliferative activity of Schwann cels were detected, and protein and gene expressions of β-catenin and nuclear factor-κB were observed. RESULTS AND CONCLUSION: At 48, 72, 96 hours after intervention, the cel viability of the model group was significantly lower than that of the normal control group (P < 0.01). Compared with the model group, the cel viability of salvianolic acid B group (10 μmol/L) was significantly increased at 72 and 96 hours (P < 0.05); the expressions of nuclear factor-κB protein and mRNA in the methylprednisolone group and salvianolic acid B group were declined significantly (P < 0.01), but the expressions of β-catenin mRNA and protein in the salvianolic acid B group significantly increased (P < 0.05). These results suggest that salvianolic acid B improves the viability of Schwann cels which are stimulated with lipopolysaccharide, suppresses expression of nuclear factor-κB mRNA and protein, and promotes the expression of β-catenin mRNA and protein. Above may be one of the mechanisms which salvianolic acid B protects Schwann cels.

The effects of intravcntricular administration of ?-amino - butyric acid (GABA) and its antagonist picrotoxin(PTX) on the discharges of dorsal hippocampal nocieeptive neurons are investigated The noxious discharge of 28 (67%) nociccptive exciting neurons (NENS) are depressed (p

This article probed the significance of college English course in moral education for medical college students and how to cultivate the medical students" ethical moral in English class.In addition,as the English teachers of the medical college,they should learn medical knowledge as well as make excellent models by their own personality for students to establish their professional ethics.

Carotid artery stenosis is identified more and more common in clinical,and gradually become one of the causes of death and disablement.With the continuous development of medical technology,and medical device and apparatus equipment,surgical therapy and endovascular therapy have become one of the major principal methods in treatment of carotid artery stenosis.This article briefly discusses the current several processes and techniques of the surgical and endovascular treatment of carotid stenosis disease,and carries on the evaluation.

OBJECTIVE:To provide references for rational,efficient and economical use of NSAID in the clinic.METH-ODS:The varieties,sales volume,DDDs etc.of NSAID used in10hospitals of Tanjin during2002～2003were analyzed sta-tistically.RESULTS:The drugs that dominated the front7places were almost the same as those that dominated the first7places on the list of sales volume for the2years.The traditional NSAID were widely used in the clinic,the markets share for a certain drug kept increasing.CONCLUSION:The clinical application of NSAID in Tianjin was rational,those drugs that of low prices but of certain curative effect take a dominance in the clinical adoption.

ObjectiveTo explore the effect of health education on uncertainty in illness and hope level of patients with acute coronary syndrome.Methods100 patients with acute coronary syndrome were randomly divided into the control group and the observation group with 50 patients in each.The control group received routine treatment,the observation group was given health education based on routine treatment.After treatment Mishel Uncertainty in Illness Scale(MUIS)and Herth hope index(HHI)scale were used for effect evaluation.ResultsThere were no significant differences on MUIS and HHI scores between two groups before nursing intervention.But after nursing intervention,MUIS score was lower and HHI score was higher in the observation group than those of the control group.ConclusionsHealth education on patients with acute coronary syndrome can reduce the uncertainty in illness and improve the level of their hopes.

Objective To observe the efficacy of the combined treatment of Reduning,budesonide and erythromycin sequential therapy in the treatment of children with mycoplasma pneumonia and investigate its mechanism.Methods 78 children with mycoplasma pneumonia were randomly divided into two groups,each group 39 cases.The control group were given budesonide and erythromycin sequential therapy,and the observation group were given Reduning injection on the basis of the control group.Both groups were treated for 2 weeks.The clinical efficacy was observed,and before and after treatment,the pulmonary function was tested in the both groups.Results The total effective rate of the observation group was 94.87％,which was higher than that of the control group(86.62％)(x2=6.683,P＜0.05);The fever,cough improved,pulmonary rales disappeared,wheeze disappeared and hospital stay time of the observation group were significantly shorter than the control group(all P＜0.01);The FVC,FEV1 and PEF of the observation group were higher than those of the control group(all P＜0.05).Conclusion On the basis of the combined treatment of budesonide and erythromycin,the addition of Reduning injection can improve clinical effect and shorten the symptoms and signs improve time,improve lung function,chich may in association with regulating humoral immunity and reducing the levels of inflammatory cytokines.

Objective To investigate the expression of vascular endothelial growth factor (VEGF) or matrix metalloproteinase-9( MMP-9) in pancreatic carcinoma( PCA) and its clinical significance.Methods The expression of VECF and MMP-9 in 50 PCA tissues and in 20 normal pancreatic tissues were examined by immunohistochemistry.Results The expression of VECF and MMP-9 was higher in PCA than that in its surrounding parenchyma and normal pancreatic parenchyma( x2 = 2.82,2.96, all P < 0.05 ) ; The expression of VEGF and MMP-9 were related to the tumor differentiation,the clinical stage and the lymphnode metastasis.Conclusion VECF and MMP-9 should play important role in the invasion and metastasis of PCA, and had a certain significance for predicting recurrence and metastasis of pancreatic cancer.

Objective To observe the effect of humanistic care on blood pressure control of elderly patients with hypertension. Methods 138 elderly patients with hypertension patients in our hospital were randomly divided into the intervention group and the control group with 69 cases in each group, the intervention group received anti-hypertensive medication as well as the system of nursing intervention,and the control group only was given simple drug treatment. The blood pressure control results were compared. Results SCL-90 factor of the intervention group was significantly higher than the Chinese module before intervention, and SCL-90 factors after intervention was significantly lower than before intervention. In the intervention group, the total effective rate of blood pressure control was 92.75%, significantly higher than the control group. Conclusions Humanistic nursing interventions to elderly patients with hypertension with various forms and more ways can effectively control the blood pressure, improve the therapeutic effects, improve nursing satisfaction degree and quality of care and is worthy of promotion and application.