Alveolitis, Extrinsic Allergic ; Humans ; Occupational Diseases

Alveolitis, Extrinsic Allergic ; Humans ; Metallurgy ; Occupational Diseases

Congresses as Topic ; Humans ; Infection ; Nose Diseases ; microbiology ; Nose Neoplasms ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial

Alveolitis, Extrinsic Allergic ; diagnosis ; therapy ; Humans ; Occupational Diseases ; diagnosis ; therapy

Interleukin 31 (IL-31)is one of the cytokines which appears to be an important regulator of Th2 responses. Previous study has been done to determine IL-31 serums levels in atopic dermatitis (AD). However, the serum levels of IL-31 in allergic rhinitis (AR) and atopic asthma (AA) is not many reported and still unclear. The objective of this cross sectional study is to determine an association between IL-31 and other predisposing factors with allergic diseases in HRPZ II (Hospital Raja PerempuanZainab II) and HUSM (Hospital UniversitiSains), Kelantan, Malaysia. This study involved 70 patients of AD, 70 patients of AR, 70 patients of AA and 70 healthy controls from staffs and people in HUSM.Five milliliters of blood were withdrawn and centrifuged for 5 minutes at 2000 rpm to obtain the serum and analyzed for IL-31 levels by using enzymelinked immunosorbent (ELISA) kits (Human IL 31 Duoset, R&D System). Simple and multiple logistic regressions were used to analyze the association between IL-31 levels and predisposing factors among allergic diseases. The levels of IL-31 and other predisposing factors showed significant associations in smoking status, occupational exposure and area of living for AD and AR, however in AA, the significant association only found in smoking status and occupational exposure. In conclusion, we found that there were associations between IL-31 serum levels and other predisposing factors with AD, AR and AA. The findings can be the pilot study to determine IL-31 levels in allergic diseases in Malaysia.
IL-31 ; serum levels ; predisposing factors ; allergic diseases ; Kelantan

BACKGROUND: Cheilitis is a common problem, the cause of which is often obscure. OBJECTIVE: We evaluated the frequency of allergic contact cheilitis and irritant contact cheilitis among 23 eczematous cheilitis patients via patch testing and assessment of past medical history. METHODS: This study consisted of 23 patients with eczematous cheilitis who had visited the Department of Dermatology, two University Hospital in Incheon, between January 2005 and August 2006. Of the 23 patients, 20 were female, and the age range was 15 to 70 years. We analyzed the clinical characteristics (age, gender, duration, atopic or allergic disease, lip licking) of the patients. All patients were patch-tested with the Korean standard series, 9 patients with the Cosmetic series and 5 patients with as is test. We then analyzed the results of the patch tests and evaluated the relevance of any positive results. RESULTS: Of the cases, 34.78% were identified as irritant contact dermatitis (ICD), and 30.43% as allergic contact dermatitis (ACD). Furthermore, of the 23 patients, 11 were positive to one or more antigen and 7 of these had a clinical relevance for positive antigen. The substances causing a positive reaction, triggering ACD were identified as medicaments applied to the lip, lipstick ingredients and toothpaste. CONCLUSION: The most common cause of cheilitis was irritation, frequently caused by lip licking. But, almost one third was caused by ACD. Patients with chronic eczematous cheilitis should be patch-tested to identify the materials causing ACD.
Cheilitis* ; Dermatitis, Allergic Contact ; Dermatitis, Contact ; Dermatology ; Female ; Humans ; Incheon ; Lip ; Lip Diseases ; Patch Tests* ; Toothpastes

PURPOSE: To determine the prevalence of dry eye disease (DED) and risk factors among young people based on the Ocular Surface Disease Index (OSDI) questionnaire. METHODS: The authors of the present study distributed the OSDI questionnaire to 263 university students. DED was diagnosed when the OSDI score was greater than 13 points. According to the OSDI score, DED was classified as mild (13-22 points), moderate (23-32 points), or severe (33-100 points). Additionally, the associations between the OSDI score and possible risk factors such as gender, contact lens use and allergic conjunctivitis were studied. RESULTS: Of 263 students, diagnosed DED was present in 133 (50.6%) and severe cases of DED were observed in 49 (18.6%). A high OSDI score was associated with female sex (p < 0.01), a history of allergic conjunctivitis (p = 0.02), contact lens use (p < 0.01), self-awareness of the dry eye symptoms (p < 0.01) and a history of clinically diagnosed DED (p < 0.01). CONCLUSIONS: Prevalence of DED, which has been reported to be high in the elderly, was considered high at 50.6% among young people in the present study. Caution or education regarding DED is necessary for people who have a high OSDI score, particularly females, contact lens wearers and people with allergic conjunctivitis.
Aged ; Conjunctivitis, Allergic ; Eye ; Eye Diseases ; Female ; Humans ; Prevalence ; Surveys and Questionnaires ; Risk Factors ; Young Adult

Hypersensitivity pneumonitis (HP) is an immunologically-mediated disease resulting from repeated exposure to sensitizing agents, such as organic dusts or chemicals. Isocyanate is a volatile and highly reactive chemical that is extensively used in the manufacturing of automobiles, upholstery, and polyurethane foam. Occupational respiratory diseases associated with isocyanate, such as bronchial asthma, are well-known. It is thought that HP is one of the rare diseases induced by isocyanate with a very low frequency worldwide. We report a case of HP in an automobile painting sprayer which appeared to be associated with isocyanate.
Alveolitis, Extrinsic Allergic ; Asthma ; Automobiles ; Dust ; Hypersensitivity ; Paint ; Paintings ; Polyurethanes ; Rare Diseases

Allergic bronchopulmonary aspergillosis (ABPA), an asthmatic disease, is caused primarily by hypersensitivity to Aspergillus species. ABPA is rarely observed in the absence of asthma, which is, in fact, the principle criterion for its diagnosis. Here, we report the case of a 36-yr-old woman without a history of bronchial asthma, who manifested a localized pneumonic consolidation, coupled with broncholithiasis. Pathologic examinations of bronchoscopic biopsy specimens and resected surgical specimens revealed features typical of ABPA. This is a very rare case of ABPA coupled with broncholithiasis in a non-asthmatic individual.
Lithiasis/*complications/*diagnosis ; Humans ; Female ; Bronchial Diseases/*complications/*diagnosis ; Asthma ; Aspergillosis, Allergic Bronchopulmonary/*complications/*diagnosis ; Adult

Authors have performed patch test to evaluate the differences between the allergic contact dermatitis to topical medicaments and to the other substances including cosmetics. One hundred eighteen patients were evaluated according to age, sex, and causative agents of the disease. Furthermore, these patients were analysed as to the causative allergic contact factors by clinical inspection and history. The most common causative allergic contact factors by clinical, history and patch test were topical medicarnents(45.8%), cosmetics(24. 6%), rubbery(10.2%), and metals(8.59%.). The common etiogloic medicaments of contact dermatitis were Madecassol, Betadin, Tiger balm, Canesten, Mercurochrom, and Tego solution. The causative agents were confirmed by the patch test with Hollister-Stiers standard allergens in 57 patients from Jan. 1983 to Dec. 1984, 1 hirty eight among 57 patients were positive to patch test, Back ground possible explanation of the patch test results were discussed and a comparison was made between this report and others.
Allergens ; Clotrimazole ; Dermatitis, Allergic Contact ; Dermatitis, Contact ; Humans ; Hypersensitivity, Delayed* ; Patch Tests ; Skin Diseases* ; Tigers