5.Association Between Il-31 Serum Levels And Other Predisposing Factors With Allergic Diseases In Hrpz Ii And Husm, Kelantan, Malaysia
Siti Noor Syuhada Muhammad Amin ; Noor SuryaniMohd Ashari ; Wan Zuraida Wan Abd. Hamid ; AzrianiAb Rahman ; Azman Azid
Malaysian Journal of Public Health Medicine 2017;2017(Special Volume (2)):66-73
Interleukin 31 (IL-31)is one of the cytokines which appears to be an important regulator of Th2 responses. Previous study has been done to determine IL-31 serums levels in atopic dermatitis (AD). However, the serum levels of IL-31 in allergic rhinitis (AR) and atopic asthma (AA) is not many reported and still unclear. The objective of this cross sectional study is to determine an association between IL-31 and other predisposing factors with allergic diseases in HRPZ II (Hospital Raja PerempuanZainab II) and HUSM (Hospital UniversitiSains), Kelantan, Malaysia. This study involved 70 patients of AD, 70 patients of AR, 70 patients of AA and 70 healthy controls from staffs and people in HUSM.Five milliliters of blood were withdrawn and centrifuged for 5 minutes at 2000 rpm to obtain the serum and analyzed for IL-31 levels by using enzymelinked immunosorbent (ELISA) kits (Human IL 31 Duoset, R&D System). Simple and multiple logistic regressions were used to analyze the association between IL-31 levels and predisposing factors among allergic diseases. The levels of IL-31 and other predisposing factors showed significant associations in smoking status, occupational exposure and area of living for AD and AR, however in AA, the significant association only found in smoking status and occupational exposure. In conclusion, we found that there were associations between IL-31 serum levels and other predisposing factors with AD, AR and AA. The findings can be the pilot study to determine IL-31 levels in allergic diseases in Malaysia.
IL-31
;
serum levels
;
predisposing factors
;
allergic diseases
;
Kelantan
6.Prevalence of Dry Eye Disease among University Students.
Cheol Min YUN ; Su Yeon KANG ; Hyo Myung KIM ; Jong Suk SONG
Journal of the Korean Ophthalmological Society 2012;53(4):505-509
PURPOSE: To determine the prevalence of dry eye disease (DED) and risk factors among young people based on the Ocular Surface Disease Index (OSDI) questionnaire. METHODS: The authors of the present study distributed the OSDI questionnaire to 263 university students. DED was diagnosed when the OSDI score was greater than 13 points. According to the OSDI score, DED was classified as mild (13-22 points), moderate (23-32 points), or severe (33-100 points). Additionally, the associations between the OSDI score and possible risk factors such as gender, contact lens use and allergic conjunctivitis were studied. RESULTS: Of 263 students, diagnosed DED was present in 133 (50.6%) and severe cases of DED were observed in 49 (18.6%). A high OSDI score was associated with female sex (p < 0.01), a history of allergic conjunctivitis (p = 0.02), contact lens use (p < 0.01), self-awareness of the dry eye symptoms (p < 0.01) and a history of clinically diagnosed DED (p < 0.01). CONCLUSIONS: Prevalence of DED, which has been reported to be high in the elderly, was considered high at 50.6% among young people in the present study. Caution or education regarding DED is necessary for people who have a high OSDI score, particularly females, contact lens wearers and people with allergic conjunctivitis.
Aged
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Conjunctivitis, Allergic
;
Eye
;
Eye Diseases
;
Female
;
Humans
;
Prevalence
;
Surveys and Questionnaires
;
Risk Factors
;
Young Adult
7.A Case of Hypersensitivity Pneumonitis in an Automobile Paint Sprayer.
Mi Na OH ; Myoung Jin CHO ; Hoon Ki BAEK ; Ki Sung CHO ; Ji Hoon KANG ; Young KIM ; Jin Young KWAK
Tuberculosis and Respiratory Diseases 2008;65(6):541-545
Hypersensitivity pneumonitis (HP) is an immunologically-mediated disease resulting from repeated exposure to sensitizing agents, such as organic dusts or chemicals. Isocyanate is a volatile and highly reactive chemical that is extensively used in the manufacturing of automobiles, upholstery, and polyurethane foam. Occupational respiratory diseases associated with isocyanate, such as bronchial asthma, are well-known. It is thought that HP is one of the rare diseases induced by isocyanate with a very low frequency worldwide. We report a case of HP in an automobile painting sprayer which appeared to be associated with isocyanate.
Alveolitis, Extrinsic Allergic
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Asthma
;
Automobiles
;
Dust
;
Hypersensitivity
;
Paint
;
Paintings
;
Polyurethanes
;
Rare Diseases
8.Clinical Study of the Results of Patch Test in Patients with Eczematous Cheilitis.
Jong rok LEE ; Hye Young LEE ; Jin Ok BAEK ; Ju Young ROH ; Gwang Seong CHOI
Korean Journal of Dermatology 2007;45(1):9-13
BACKGROUND: Cheilitis is a common problem, the cause of which is often obscure. OBJECTIVE: We evaluated the frequency of allergic contact cheilitis and irritant contact cheilitis among 23 eczematous cheilitis patients via patch testing and assessment of past medical history. METHODS: This study consisted of 23 patients with eczematous cheilitis who had visited the Department of Dermatology, two University Hospital in Incheon, between January 2005 and August 2006. Of the 23 patients, 20 were female, and the age range was 15 to 70 years. We analyzed the clinical characteristics (age, gender, duration, atopic or allergic disease, lip licking) of the patients. All patients were patch-tested with the Korean standard series, 9 patients with the Cosmetic series and 5 patients with as is test. We then analyzed the results of the patch tests and evaluated the relevance of any positive results. RESULTS: Of the cases, 34.78% were identified as irritant contact dermatitis (ICD), and 30.43% as allergic contact dermatitis (ACD). Furthermore, of the 23 patients, 11 were positive to one or more antigen and 7 of these had a clinical relevance for positive antigen. The substances causing a positive reaction, triggering ACD were identified as medicaments applied to the lip, lipstick ingredients and toothpaste. CONCLUSION: The most common cause of cheilitis was irritation, frequently caused by lip licking. But, almost one third was caused by ACD. Patients with chronic eczematous cheilitis should be patch-tested to identify the materials causing ACD.
Cheilitis*
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Dermatitis, Allergic Contact
;
Dermatitis, Contact
;
Dermatology
;
Female
;
Humans
;
Incheon
;
Lip
;
Lip Diseases
;
Patch Tests*
;
Toothpastes
9.Usefulness of the MAST in Allergic Skin Diseases.
Hye Jung JUNG ; Mi Youn PARK ; Jai Il YOUN ; Ji Young AHN
Korean Journal of Dermatology 2014;52(6):387-393
BACKGROUND: Allergic skin diseases such as atopic dermatitis and urticaria are known to be mediated by IgE. It is important to confirm a causative allergen for diagnosis and treatment. The multiple allergosorbent test (MAST) is a simple method for simultaneously measuring total and allergen-specific IgE. OBJECTIVE: The purpose of this study was to analyze results from the MAST, which measures total and specific IgE, and to compare the different results. METHODS: We reviewed the MAST results of 270 allergic disease patients tested between June 2007 and May 2012. RESULTS: There were statistical differences in total IgE production and in positive sensitization to specific allergens between the disease groups. The level of total IgE and positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, allergic contact dermatitis, and pruritus patients. Atopic dermatitis patients had significantly more allergens than those with other diseases. There were no statistical differences in total IgE level, rates of positive sensitization to specific allergens, and the number of causative allergens between the patients with acute and chronic urticaria. CONCLUSION: Each disease showed a different IgE pattern. Atopic dermatitis showed the highest level of serum IgE. There were no differences in IgE levels between acute and chronic urticaria patients. We identified an increase in IgE level in allergic contact dermatitis patients. Further study is needed to determine whether these patterns could be useful in diagnosis and choice of treatment methods.
Allergens
;
Dermatitis, Allergic Contact
;
Dermatitis, Atopic
;
Diagnosis
;
Humans
;
Immunoglobulin E
;
Immunoglobulins
;
Pruritus
;
Skin Diseases*
;
Urticaria
10.In Vivo Delayed Hypersensitivity to the Recall Antigens in Different Dermatoses.
Chun Wook PARK ; Sung Woo CHOI ; Hyung Ok KIM ; Chung Won KIM
Korean Journal of Dermatology 1985;23(4):441-446
Authors have performed patch test to evaluate the differences between the allergic contact dermatitis to topical medicaments and to the other substances including cosmetics. One hundred eighteen patients were evaluated according to age, sex, and causative agents of the disease. Furthermore, these patients were analysed as to the causative allergic contact factors by clinical inspection and history. The most common causative allergic contact factors by clinical, history and patch test were topical medicarnents(45.8%), cosmetics(24. 6%), rubbery(10.2%), and metals(8.59%.). The common etiogloic medicaments of contact dermatitis were Madecassol, Betadin, Tiger balm, Canesten, Mercurochrom, and Tego solution. The causative agents were confirmed by the patch test with Hollister-Stiers standard allergens in 57 patients from Jan. 1983 to Dec. 1984, 1 hirty eight among 57 patients were positive to patch test, Back ground possible explanation of the patch test results were discussed and a comparison was made between this report and others.
Allergens
;
Clotrimazole
;
Dermatitis, Allergic Contact
;
Dermatitis, Contact
;
Humans
;
Hypersensitivity, Delayed*
;
Patch Tests
;
Skin Diseases*
;
Tigers