Objective To investigate the effect of borneol on levels of monoamine neurotransmitters in the prefrontal cortex of rat after long-term continuous operations.Methods A rat model of long-term continuous operations were established by using a treadmill protocol.Then Borneol(0.4 g/kg,p.o.) was given to the rats after the operation,and their activity-rest behavior and active avoidance response were assessed.Two h later,the rats were sacrificed and the level of monoamine neurotransmitter in the prefrontal cortex was determined by high performance liquid chromatography combined with electrochemical detection(HPLC-ECD).Results After the administration of borneol,the activities of operational animals were increased markedly as compared with that of vehicle operational group.The operational rats after borneol application had less response time than the ones treated with vehicle(6.85?1.24) s in active avoidance response.The levels of monoamine neurotransmitters including noradrenaline,dopamine,and 5-serotonin in the prefrontal cortex were decreased after treadmill operation.While application of borneol made the levels of noradrenaline and 5-serotonin increased significantly as compared to operational group.Conclusion Borneol have a reversal effect on rat awake activity impairment after long-term continuous operations.And the arousal effects of borneol are associated with the increase of noradrenaline and 5-serotonin levels in the prefrontal cortex.

Objective Onto observe the curative effect of carboprost tromethamine injection combined with mifepristone on the treatment of the patients with risky placenta previa. Methods 66 cases with placenta previa during mid pregnancy from January 2016 to December 2016 in Dingbian county people's hospital were randomly divided into two groups, 33 cases in the control group and 33 cases in the observation group. All patients were received cesarean section and traditional treatments such as oxytocin and gauze filling. Hemostatic effect, prognosis and incidence of adverse reactions in the two groups were compared. Results The intraoperative bleeding volume, the amount of vaginal bleeding 2 hours after operation and the amount of vaginal bleeding 2 to 24 hours after operation in the observation group were less than those in the control group (P<0.05). The rate of postpartum hemorrhage, the rate of disseminated intravascular coagulation and the incidence of puerperal disease in the observation group were significantly less than those in the control group (P<0.05). The sanguinous lochia time and menstrual recovery time in the observation group were better than those in the control group (P<0.05). There was no significant difference in the rate of hysterectomy and adverse reactions between the two groups. Conclusion Carboprost Tromethamine Injection combined with mifepristone in the treatment of pernicious placenta previa can effectively reduce the bleeding rate and promote the rehabilitation of pregnant women. It is safe and has no obvious adverse reactions. It is worthy of clinical application.

Neuroblastoma(NB) is the most common extracranial solid malignant tumor in childhood,which has various clinical manifestations.Tumor metastasis or relapse is one of the major causes of death in patients with NB.At present,the treatments of NB are mainly concentrated on the surgery,chemotherapy,radiation therapy,myeloablative therapy and transplantation,tumor targeted therapy,etc.But the treatment of children with high-risk NB is still not optimistic.Studies have shown that multidmg resistance is a major impediment to the successful treatment of NB.Hence,it is of great significance to have a comprehensive understanding of the chemoresistance mechanisms to improve the survival rate of NB patients.This review discusses the chemoresistance mechanisms of NB in several respects.

So far,the unified definition and diagnostic criteria of feeding intolerance in preterm infants is still unavailable,although they have always been modified and improved.The curative effects of intervention strategies,including the feeding strategies,breast-feeding,medication,and so on,still need multiple clinical randomized studies in order to be verified and evaluated.Therefore,this article will summarize the progress in the definition of feeding intolerance,feeding strategies and medication.

Objective To explore the management status of long term care hospital nursing workers and find out appropriate countermeasures.Methods By using the methods of questionnaire survey and interview,management status of nursing workers from similar hospitals was investigated.The results were explored and applied combined with the nursing management of our hospital.Results Satisfaction degree of patients and their families about nursing workers increased from 76.7％ to 97.4％.Conclusions It is of key importance that continuous exploration and improvement of hospital nursing workers management be implemented to enhance the high quality nursing of elderly chronic disease hospital.

OATP1B3, a member of SLC superfamily, is specifically expressed on the sinusoidal membrane of hepatocytes and is considered to be important in hepatic drug elimination. The overexpression of OATP1B3 was found recently in tumor tissues such as prostate, colon, and pancreatic tumors. Sequence variations in SLCO1B3 gene, such as SNPs, have been described and a common haplotype consisting of 334T>G and 699G>A SNPs is related to altered transport characteristics of OATP1B3. OATP1B3 is of relevance to drug metabolism through affecting alteration of hepatic concentration of endo- and xenobiotic compounds that interact with nuclear receptors such as PXR and CAR, and thereby directly alter the extent of target gene transcription, including major CYP isoenzymes such as CYP3A4. This review will provide an overview of substrates and inhibitors of OATP1B3 and subsequently to assess the effect of genetic mutation on transport activity. The studies linking OATP1B3 with cancer clinical outcomes are also discussed in this review.

The study aims to observe the clinical efficacy of Baoerkang san on spleen-deficiency and dampness-obstructing diarrhea in children. Children diarrhea divided into acute diarrhea (group I) and chronic persistent diarrhea (group II). A randomized, double-blind, positive control test was conducted for dose finding. The 340 cases with acute diarrhea in group I were divided into three groups: the high dose group (112 patients), the low dose group (113 patients) and the positive control group (115 patients), which were treated for 3 days. Their clinical efficacies were compared to evaluate the clinical safety of Baoerkang san. The 167 patients with chronic persistent diarrhea in group If were divided into the high dose group (56 patients), the low dose group (55 patients) and the control group (56 patients), which were treated for 5 days. Their clinical efficacy were compared to evaluate the clinical safety of Baoerkang san. According to the results, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P <0. 05, P < 0.01). In the treatment of spleen-deficiency and dampness-obstructing diarrhea with traditional Chinese medicines, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P < 0.05, P < 0.01). During the test, all of the three groups did not suffer any adverse event, with no any abnormality in general physical indexes. In conclusion, Baoerkang san shows a significant efficacy in treating acute diarrhea and chronic persistent diarrhea (spleen-deficiency and dampness-obstructing) and safe clinical application.
Child ; Child, Preschool ; Diarrhea ; drug therapy ; physiopathology ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Infant ; Male ; Phytotherapy ; Spleen ; drug effects ; physiopathology ; Treatment Outcome

Objective To test the reliability and validity of the collective self-esteem scale for freshman.Methods 800 freshmen finished the Collective Self-Esteem Scale,the Life Satisfaction Scale,and Self-esteem Scale.Results The confirmatory factor analysis shows that collective esteem includes membership esteem,private collective esteem,public collective esteem,and importance to identiy intemal consistency a of the scale and the 4 components of the scale ale between0.6357and 0.8369.All components of the scale except importance to identity have significantly positive correlation with life satisfaction and self-esteem.(0.14＜r＜0.41,P＜0.01).Gids have more scores than boys in total collective esteem(t=3.38,P＜0.01),Private CSE and Importance to Identity (t=3.32,P＜0.01).Conclusion The revised collective self-esteem scale for freshmen has sound reliability and validity.It is a good instrument for measuring collective self-esteem of Chinese freshman.

Objective To observe the dynamic changes of renin-angiotensinsystem,collagen I(CoI) and intercellular adhesion molecule 1(ICAM-1) in hmg tissue of neonatal rats with lung fibrosis induced by hyperoxia.Methods One hundred and twenty term neonatal Wistar rats were randomly assigned into model group and air control group.The model group was continuously exposed to hyperoxia (FiO2=0.9)for 21 days,and the air control group was exposed to room air(FiO2=0.21).On the Ist,3rd,7th,14th and 21st day of exposure,the subjects were sacrificed.And then,the protein levels of CoI,ICAM-1 were measured by enzyme-linked immunosorbentassay and angiotensinII(AngII) by radio-immunity technique,the activity of angiotensin-convertion enzyme(ACE) were measured by biochemistry analysator,and the mRNA expression of ACE,AngII,CoI was measured by RT-polymerase chain reaction.The changes of lung histomorphology were observed.Results The ACE,AngII,CoI and ICAM-1 protein lev els of model group were (249.20±20.19)μg/g,(838.22±197.75)μg/g,(539.85±81.03) μg/g and (577.06±61.17)μg/g on the 14th day respectively and in.eased significantly as compared to the air control group (P＜0.05),and the ACE,AngII,CoI mRNA expression of modal group also increased signficantly on the 14th day (P＜0.05).The ACE,AngII,CoI and ICAM-1 protein levels of model group were(249.20±20.19)μg/g,(838.22±197.75)μ/g,(539.85±81.03)μg/g and (577.06±61.17)μg/g on the 21st day and increased to the peak respectively(P＜0.05),and the ACE,AngII and CoI mRNA expression had the same changes as well.The histopathological examination demonstrated different degrees of fibrosis in the model group.Conclusion The ACE,AngII,CoI and ICAM-1 protein levels and their mRNA expression were increased significantly on the 14th and 21st day in lung tissue of neonatal rats with lung fibrosis induced by hyperoxia.The renin-angiotensin system played a role in lung fibrosis induced by hyperoxia.

Objective To observe the effect of lowering intraocular pressure(IOP) treatment on ocular hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).Methods A total of 68 patients with NAION (68 eyes) were enrolled in this study.The patients were randomly divided into treatment group (38 eyes of 38 patients) and control group (30 eyes of 30 patients).All the patients were received methylprednisolone pulse therapy (200 mg,three days),vasodilator therapy with intravenous infusion of Xueshuantong solution (300 mg),optic nerve nutritional therapy with mouse nerve growth factor (30 μg) and acupoint injection in temporal with compound anisodine (2 ml).The total course was 10 days.The patients of treatment group received IOP lowering treatment to reduce the IOP to ≥ 8 mm Hg (1 mm Hg=0.133 kPa) or in a 30％ reduction.The patients of control group received no IOP lowering treatment.The peak systolic velocity (PSV),pulsatility index (PI) and resistance index (RI) of ophthalmic artery (OA),central retinal artery (CRA) and short posterior ciliary arteries (PCA) before and after treatment were comparatively analyzed by color doppler flow imaging.Results The differences of PSV (t=1.023,1.145,0.569),PI (t=0.679,0.956,1.634) and RI (t=0.816,1.657,0.998) of OA,CRA and PCA before treatment in treatment group and control group were not statistically significant (P＞ 0.05).Compared with before treatment,PSV (t=3.150,7.650,3.520) and PI (t=2.420,5.430,7.650) of OA,CRA and PCA increased obviously (P＜0.05),RI of OA,CRA and PCA decreased obviously (t=5.320,9.640,18.360; P＜0.05) after treatment in treatment group.In control group,the differences of PSV (t=2.090,-2.550,-2.100) and PI (t=-2.310,-2.230,-4.490) of OA,CRA and PCA between before and after treatment were not statistically significant (P＞0.05) ; but the differences of RI of OA,CRA and PCA between before and after treatment was statistically significant (t=2.970,2.160,2.690μ P＜0.05).Compared with control group,PSV (t=2.632,2.135,5.364) and PI (t=3.251,2.432,4.243) of OA,CRA and PCA increased obviously (P＜0.05),RI of OA,CRA and PCA decreased obviously (t=3.664,2.938,4.324; P＜0.05) after treatment in treatment group.Conclusion Lowering intraocular pressure treatment can improve the ocular hemodynamics in NAION patients.