AIM: To study the effects of indapamide and nifedipine in treating the patients with mild to moderate hypertension and the affect to the living quality.　METHODS: One hundred and twenty seven patients with mild to moderate hypertension were divided into two groups, indapamide group 67 patients (M 30, F 37; age 63 a± s 12 a) received indapamide 2.5 mg, po, tid ×2 mo; nifedipine group 60 patients (M 30, F 30; age 61 a±12 a) received nifedipine 10 mg, po, tid× 2 mo.　RESULTS: Both above medicines could reduce blood pressure effectively (P>0.01), and there was no obvious affect to the lipid, renal function, uric acid, electrolyte. Indapamide group had the results of getting living quality improved; while nifedipine group had that of increasing some self testing sonse symptoms and ling quality reduced.　CONCLUSION: Both indapamide and nifedipine have definite effects in treating hypertension, while no obvious bad affect on blood lipid, renal function, et al. But the indapamide is less adverse reaction, and superior to nifedipine on the aspect of improving living quality.