Objective: To observe the improvement of symptom and cardiac function after intervention on depressive mood in patients with myocardial infarction (MI) Methods: Among 76 patients with MI, 47 with depressive mood (according to results of SDS and HRSD) were randomly divided into intervention group (n=26) and control group (n=21), the former received health education and supportive therapy, some with major depression received antidepressant for 3 months Three months later, both groups were assessed with SDS and HRSD again, as well as assessments of symptoms of heart disease and cardiac function Results: The scores of SDS and HD in both groups were lower 3 month later (P