Transforming growth factor ?1 (TGF ?1) promotes the formation of extracellular medium(ECM).This study was designed to investigate the effects of angiotensinⅡ(AngⅡ) and Interferon ?(IFN ?) on expression of TGF ? Receptor type I(T?R I) in rat vascular smooth muscle cell(VSMC). We observed the changes of T?R I expression after 24h stimulation with AngⅡ(10 -7 M) and IFN ?(500U/ml) by Western blotting, and found that AngⅡ markedly stimulated expression of T?R I from 62 24?4 39 in control group to 103 06?9 34 in AngⅡ group (expressed in OD, P