Objective To evaluate the electrophysiological change in patients with acute tetrodotoxin(TTX) poisoning.Methods The electromyogram, motor nerve conduction velocity(MCV), sensory nerve conduction velocity(SCV),F wave,H reflex and somatosensory evoked potentials(SEP) were randomly detected in 58 patients with acute TTX poisoning.Results 22 patients with TTX(37.9%) detected by the electromyogram showed mainly polyphase irregular waves;MCV and SCV were weakened; SCV was even more remarkable,the latency of distant MCV action potentials was prolonged obviously, the abnormality rate of nerve conduction velocity was much higher than that of fibrillation,the detectable rats of positive wave was high,the low abnormality rate of F wave and H reflex suggested that the ill TTX poisoning involved the nerve roots;the abnormality rate of SEP was 56.9%.Conclusion TTX poisoning can company with the damage of central nerves, the measure of electroneurophysiology can be used to observe the extent,course and range of nerve system damage in patients with acute TTX poisoning, and it is one of the early detection means of this disease.