objective: To evaluate the clinical effect of various materials used in the reconstruction of mandibular defects retrospectively. Methods: 467 patients with mandibular defects were treated with various implantation materials during last 30 years and 395 of them were followed up.Results: 217 were satisfied with their mouth opening, occlusion and maxillofacial contour after sugery, 189 of them had bone transplanation and 28 had non biomateria transplantaion; 91 were partly satisfied, 72 of them had bone trasplantation and 19 had non biomateria; 87 were not satisfied, 11 of them had bone trasplantation and 76 had non biomaterial. Conclusion: Bone especially auto bone transplantation is more effective than non biomaterial in the reconstruction of mandibular deffects.

Objective To study the expression levels of serum HSP70 and p53 in gastric cancer and its cor-relation with helicobacter pylori infection.Methods 50 patients with gastric cancer were selected as the research object.Among 50 cases,30 cases were stage Ⅰ -Ⅱ,20 cases were stage Ⅲ,22 cases were with lymph node metasta-sis and 28 cases were without lymph node metastasis.40 healthy subjects were selected as the healthy control group. The serum levels of HSP70 and p53 were detected.Results In the gastric cancer group,the serum levels of HSP70 and p53 were markedly higher than those of the healthy control group,and the difference was statistically significant (t =12.53,16.79,all P <0.01).Moreover,with progressing of clinical stage of gastric cancer,the serum levels of HSP70 and p53 showed a trend of increasing(t =4.68,5.29,all P <0.01).The serum expression levels of HSP70 and p53 in gastric cancer with lymph node metastasis were significantly higher than those of patients without lymph node metastasis and the difference was still statistically significant(t =3.82,4.39,all P <0.01).The serum levels of HSP70 and p53 in the gastric cancer group with Hp positive were much higher,compared to those of cases with Hp negative and the difference was also statistically significant(t =4.72,4.17,all P <0.01).Conclusion In the gastric cancer patients,the serum expression level of HSP70 and p53 are increased.The expression of HSP70 and p53 are closely related to the progress and prognosis of gastric cancer and Hp infection.

Objetive:To analyze the fixation methods and sites in treatment of zygomatic complex fractures of 152 patients. Methods:The clinical data of 152 patients from 1990 to 2004 were investigated and analyzed, which focused on the changing trend of etiology and treatment methods. Results:Traffic accident was the primary reason for zygomatic complex fractures in China.152 patients received primary, timely reduction and fixation; Scalp coronal incision in combination with other incisions or alone was applied in 108 patients, the rest were treated by single local incisions. Rigid internal fixation was applied in 123 cases, and the single application of transosseous wire fixation was performed in 22 patients. 328 Ti plates were used. As to the fixation sites, 96 were applied at the zygomatic-frontal suture, 45 plates at zygomatic-maxillary suture and zygomatic crest, 92 plates at zygomatic-temporal suture, and 95 plates across the fracture line. Conclusion:Scalp coronal incision in combination with other incisions or alone can provide satisfactory outcome. Early, timely reduction and rigid internal fixation may result in better treatment results. The sites are focused at zygomatic-frontal suture, zygomatic-maxillary suture and zygomatic crest, zygomatic-temporal suture and the fracture line which restore the horizontal and vertical force route.

Objective: To study the role of transforming growth fa ctor ?1(TGF-?1) in the procession of human oral squamous cell carcinoma. Methods: Immunohistiochemical techinic was used to determine o ncogene c-myc,c-erbB2,TGF-?1 and EGFR protein expression in oral squamou s cell carcinoma cell line TSCCa and metastasis carcinoma cell line GNM treated by different levels of TGF-?1. Results: TGF-?1 showed different effects on the two cell lines. TGF-?1 significantly increased the expression of C-myc,CerbB2 and slightly enhanced TGF-?1 and EGFR protein expression in GNM cells, while TGF-?1 decreased the expression of C-myc,C erbB2,TGF-?1 and EGFR in TSCCa cells; moreover, the changes of protein ex pression of C-myc,CerbB2 were dose-dependent on TGF-?1. Conclusi on: TGF-?1 have different role in the oral squamous cell carcinoma cell lines.

Aiming to solve the problems in traditional classroom mode PBL teaching during clinical practice of oral and maxillofacial surgery,this paper investigated multi-pattern PBL teaching basing on Weblog,daily ward round and classroom discussion in the clinical practice,and focused on the practice methods,advantages and feature of this multi-pattern PBL teaching.

Objective To investigate the clinical features,etiology and risk factors of the inpatients with ischemic stroke in the Department of Cardiology.Methods The medical records of the inpatients with ischemic stroke and the inpatients in a control group were collected retrospectively.The demographics,vascular risk factors,clinical features,and other related factors were compared in both groups.Multivariate logistic regression analysis was used to analyze the independent risk factors for in-hospital ischemic stroke in the Department of Cardiology.Results A total of 2 789 inpatients in departments of cardiology were enrolled,and 26 of them (0.93％) had in-hospital stroke.One hundred thirty inpatients from 2 763 patients without in-hospital stroke were used randomly as control cases.The proportions of the inpatients of hypertension (73.08％ vs.50.77％ ; x2=4.348,P=0.037),atrial fibrillation (50.00％ vs.15.38％; x2=15.56,P=0.000),infection (30.77％ vs.7.69％ ; x2 =11.304,P =0.003),smoking (46.15％ vs.21.54％ ; x2 =6.886,P =0.009),alcohol (26.92％ vs.11.54％ ;x2 ＝ 4.233,P =0.040),previous stroke history (19.23％ vs.4.61％ ;x2 =7.062,P =0.008),and taking anti-hypertensive drugs (42.31％ vs.21.54％ ;x2 =4.985,P =0.026),as well as systolic blood pressure (143.43 ± 18.59 mm Hgvs.129.52 ± 23.52 mm Hg; t =3.209,P=0.003; 1 mmHg =0.133 kPa),diastolic blood pressure (88.77± 11.35 mm Hg vs.77.55± 14.60 mmHg; t=2.421,P =0.020),and homocysteine levels (19.27 ± 11.08 μnol/L vs.15.30 ±5.25 μmol/L; t =2.814,P =0.006) in the stroke group were significantly higher than those in the control group in the Department of Cardiology.Multivariate logistic regression analysis showed that atrial fibrillation (odds ratio [OR] 3.310,95％ confidence interval [CI] 1.207-9.076; P =0.020),infection (OR 3.270,95％ CI 1.024-10.438; P =0.045),systolic blood pressure (OR 1.023,95％ Cl 1.002-1.045; P =0.031),and homocysteine level (OR 1.089,95％ CI 1.009-1.175; P =0.029) were the independent risk factors for in-hospital ischemic stroke in the Department of Cardiology.Conclusions Atrial fibrillation,infection,systolic blood pressure,and high homocysteine levels are the independent risk factor for in-hospital ischemic stroke in the Department of Cardiology.Active intervention and control these risk factors may have great significance for reducing its risk.

Objective To generalize a valuable classification of mandibular condyle fractures and explore proper measures for such kind of fractures so as to provide reference for clinical treatment. Methods The data of 304 cases with 358 mandibular condyle fractures were analyzed retrospectively. After one year of the initial treatment, X-ray inspection was employed to get the information including mouth opening, pattern of mouth opening, occlusion, facial symmetry and healing condition of mandibular condyles. Results According to classification of position,displacement and age (PDA), 180 mandibular condyle fractures belonged to type Ⅰ, 96 to type Ⅱ and 82 to type Ⅲ, which coincided with the different fractures treated surgically or nonsurgically. All surgical and nonsurgical treatments got satisfactory outcome. Conclusion The classification of PDA is effective in guiding the treatment choice for mandibular condyle fractures. Both surgical and nonsurgical treatment can obtain effective results for corresponding case.

Objective To explore a new approach that is better than coronal scalp incision and facial percutaneous small incision in surgical treatment of zygomatic bone and zygomatic arch fracture.Methods The modified auriculotemporal incision was applied in 43 patients with zygomatic bone and zygomatic arch fracture that needed open reposition,and the exposure degree,bleeding,postoperative elasticity and texture of skin,facial nerve function and satisfactory degree were evaluated after operation.Results In present study,the upper part of zygomatic arch and lateral orbital margin could be greatly explored for operation of zygomatic bone and zygomatic arch fracture in all 43 patients by application of this approach.Less bleeding was observed during operation.All patients had primary healing and none of them presented with temporal numbness and facial palsy.After 6 months follow-up,41 cases (95.3％) and 43 cases (100％) showed fine elasticity of operative skin and satisfactory degree,respectively.Conclusions The modified auriculotemporal incision is better than conventional approach in surgical treatment of zygomatic bone and zygomaticarch fracture.

Objective: To observe the postoperative skeletal changes of mandibular setback via bilateral sagittal ramus split osteotomy (BSSRO) with circummandibular wiring and maxillomandibular fixation. Methods: BSSRO was performed in 14 cases to setback the mandible. The patients were followed up for 6 months by clinical observation and examined with lateral cephalometric radiographs and Schuller's position radiographs before and after surgery. Results: According to the measured parameters the ralapse extent was 27.2%. Multiple regression analysis showed the magnitude of the setback significantly accounted for relapse (P

Objective The main goals of orthognathic surgery are to achieve funetional occlusion and improve patient's profile.The unintended nasal change in association with anterior maxillary osteotomy is always a challenging.The purpose of this study was to improve the anterior maxillary segmental osteotomy resulting in less post-operative unintended nasal change.Methods Thirty-two patients with maxillary protrusion underwent modified anterior subapical maxillary osteotomy.The design of the modified approach was based on the anterior mandibular subapical osteotomy.The horizontal osteotomy connecting the vertical osteotomy lines on both right and left sides was performed inferior to the piriform aperture and 3 mm over the apex.The integrity of piriform aperture was maximally preserved.Lateral cephalograms,lateral and frontal photographs taken pre-and post-operatively were analyzed.All the patients were followed up for at least 6 months.Results All thirty-two patients were satisfied with esthetic outcome.The upper lip protrusions and tooth exposure improved significantly.Cephalometric and photograph analysis showed that the ratio of upper lip to maxillary ineisor retractionwas 0.64:1.00,and the nasolabial angle and philtrum length were significantly increased(P＜0.05)while vermilion length was decreased.The height of nasal tip and nasal width(alarbase to alarbase)were not significantly changed.Conclusion The modified anterior subapical maxillary osteotomy is a simple procedure leading to no significant postoperative nasal change.It provides a promising alternative in the treatment of maxillary protrusion.