Objective To explore the dynamical progeression and clinical significance of S100B and IL-1? of cerebrospinal fluid in patients with tuberculous meningitis.Methods 43 patients with TM(TM group)treated with tubercle drug and 28 patients without never diseases(control group)have been studied.S100B in Cerebrospinal Fluid were exeminated by ELISA and IL-1?by radio-immunassay.Results S100B or IL-1? of cerebrospinal fluid in patients with tuberculous meningitis increased evidently in contrast with the control group.And S100B or IL-1? of Cerebrospinal Fluid in coma patients increased evidently in contrast with no coma.Conclusion The levels of S100B in CSF could reflex the degree of damage in patients with TM.IL-1? was more sensitive to treatment.