1.Distribution of vascular endothelial growth factor gene polymorphism in Uyghur Ethnic patients with urolithiasis in south Xinjiang
Yuefu HAN ; Qinzhang WANG ; Guofu DING ; Biao QIAN ; Jiangping WANG ; Yinglong LI ; Zhao NI ; Xinmin WANG ; Shunming XIE ; Wenxiao WANG ; Zongyue CHEN ; Guodong ZHU ; Shiqi JI ; Yujie WANG ; Niwaer AN ; Guanglu SONG ; Hui WEI ; Qunying ZHANG
Chinese Journal of Urology 2010;31(9):601-603
Objective To determine vascular endothelial growth factor(VEGF)-460 gene polymorphism in Uyghurs and its relationship to urolithiasis in south Xinjiang. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP),gene sequencing and genetic analysis methods were used in 200 urolithiasis patients of Uyghurs, and 200 healthy Uyghurs. Results The distribution of genotype and allele had no significant difference between urolithiasis patients and normal controls (P＞0. 05). The frequencies for the CC,TT and CT genotypes in patients with urolithiasis and normal controls were 1.5 %, 29.0 %, 69.5 % and 0. 5 %, 27.5 %, 72.0 %, respectively. The frequencies for C and T allele were 36.2%,63.7% and 36.9% ,63.1%, respectively. Conclusions The results of VEGF-460 gene polymorphisms indicate no significant relationship between patients with turolithiasis and normal controls in Uyghurs in south Xinjiang,which may not be urolithiasis susceptibility genetic locus.
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