Insulinoma is the most common functional pancreatic neuroendocrine tumor.Surgical removal or enucleation is the most commonly used treatment.Insulinomas are usually benign,solitary and small.So they are theoretically the good indication for radiofrequency ablation (RFA) treatment.In 2009,Limmer et al ever reported the first case of insulinoma who were successfully treated by RFA.To date,5 similar articles in English have been published,reporting 7 cases in total.In the recent year,we successfully treated 2 cases with insulinoma (one in pancreatic cauda and the other in pancreatic body).All the 2 cases got complete remission with quick alleviation of clinical symptoms and without conplications.The data of these 9 cases showed that RFA is a safe and effective treatment for insulinoma,and for selected patients,it can be recommended as a treatment of first choice.