Objective To assess the clinical efficacy ofPingxiao capsule combinedLongxuejie capsule in the treatment of nodular goiter.Methods A total of 100 patients with nodular goiter from Jiangsu Provincial Hospital of Chinese Medicine were randomized into a treatment group and a control group, with 50 patients in each group. In addition to low iodine diet, the treatment group was treated withPingxiao capsule (1.15 g, thrice daily) plusLongxuejie capsule (1.2 g, thrice daily), while the control group was treated with levothyroxine sodium tablets (5 g, once daily), both for 3 months. The max diameter of thyroid nodule and the thyroid function were detected before and after the treatment.Results One patient in the treatment group and 3 patients in the control group were lost to follow-up. The max diameter of thyroid nodule were significantly decreased compared with before the treatment in the treatment group (1.49 ± 0.69 cmvs. 2.14 ± 0.87 cm;t=4.113,P=0.000) and not in the control group (1.94 ± 1.15 cmvs. 2.21 ± 1.03 cm;t=1.220,P=0.226). The free thyroxine levels were significantly increased compared with before the treatment both in the treatment group (0.83 ± 0.11 ng/dlvs. 0.77 ± 0.15 ng/dl;t=2.266,P=0.026) and in the control group (0.78 ± 0.16 ng/dlvs. 0.64 ± 0.23 ng/dl;t=3.459,P=0.001), and greater in the control group (P<0.01). The thyroid stimulating hormone level was significantly decreased compared with before the treatment in the in the control group (1.44 ± 1.59 U/mlvs. 2.28 ± 0.92 U/ml;t=3.208,P=0.002) and not in treatment group (1.98 ± 1.09 U/mlvs. 2.31 ± 0.87 U/ml;t=1.667, P=0.099). There were significant difference in free triiodothyronine levels between before and after the treatment both in the treatment group (3.31 ± 0.29 pg/mlvs. 3.27 ± 0.31 pg/ml;t=0.663, P=0.509) and in the control group (3.39 ± 0.13 pg/mlvs. 3.44 ± 0.16 pg/ml;t=1.694,P=0.094). The total effective rate in the treatment group was significantly higher than that in the control group (83.7%vs. 63.8%;χ2=3.929,P=0.048). ConclusionPingxiao capsule combinedLongxuejie capsule can reduce the size of thyroid nodules in patients with nodular goiter.

Objective To observe the curative effects of Mailuoning oral liquid combined with Mecobalamin tablets in treating aged diabetic peripheral neuropathy (DPN).Methods Forty-nine patients with DPN were randomly divided into treatment group (n=25) and control group (n=24).The patients in two groups were given Mecobalamin tablets,and the treatment group was added treated with Mailuoning oral liquid.The period of treatment was 3 months.Scores of Toronto clinical scoring system (TCSS) and traditional Chinese medicine (TCM) symptoms quantitative scale were compared between the two groups.The curative effects of all the patients were judged by the TCM symptoms quantitative scores.Results The TCSS levels in two groups after treatment were both significantly lower than those before treatment (all P<0.05).The TCSS level after treatment in treatment group was significantly lower than that in control group (P<0.05).The TCM symptoms quantitative score after treatment in treatment group was significantly lower than that before treatment (P<0.05).The TCM symptoms quantitative score after treatment in treatment group was significantly lower than that in control group (P<0.05).The total effective rate in treatment group (88%) was significantly higher than that in control group (50%) (χ2=6.631,P=0.01).Conclusion Mailuoning oral liquid combined with Mecobalamin tablets is safe and effective for treating DPN.