Recently,Sanlu Milk Powder case was bubbling with noise.The origin of this case is that the managers were seriously lack of enterprise ethics and violated bioethical norms.Enterprise ethics are not identical with enterprise social responsibility and the mutual relationship between them should be cleared up firstly.Sanlu case initiates a series of reflection on related ethical problems,including morality honesty crisis,and the lack of regular effective supervision on enterprise ethics,etc.This paper puts forward countermeasures which focus on internal and external management of enterprise and morality.

Conflicts may occur between patients' independent decision right,family members' interference right,and medical interference right.This article clarifies the applicable premise of medical interference right and explores its realistic predicaments from the ethical and legal perspectives.Reasonable system construction is a good solution to medical disputes,promoting a harmonious development of physician-patient relationship.

Multiple myeloma (MM) is still an incurable hematologic malignancy, which is eagerly to the discovery of novel therapeutic targets and methods. N-acetyltransferase 10 (NAT10) is the first reported regulator of mRNA acetylation that is activated in many cancers. However, the function of NAT10 in MM remains unclear. We found significant upregulation of NAT10 in MM patients compared to normal plasma cells, which was also highly correlated with MM poor outcome. Further enforced NAT10 expression promoted MM growth in vitro and in vivo, while knockdown of NAT10 reversed those effects. The correlation analysis of acetylated RNA immunoprecipitation sequencing (acRIP-seq) and ribosome profiling sequencing (Ribo-seq) combined with RIP-PCR tests identified centrosomal protein 170 (CEP170) as an important downstream target of NAT10. Interfering CEP170 expression in NAT10-OE cells attenuated the acceleration of cellular growth caused by elevated NAT10. Moreover, CEP170 overexpression promoted cellular proliferation and chromosomal instability (CIN) in MM. Intriguingly, remodelin, a selective NAT10 inhibitor, suppressed MM cellular growth, induced cellular apoptosis in vitro and prolonged the survival of 5TMM3VT mice in vivo. Collectively, our data indicate that NAT10 acetylates CEP1 70 mRNA to enhance CEP170 translation efficiency, which suggests that NAT10 may serve as a promising therapeutic target in MM.