The models of socal cerebral ischemia and reperfusion were produced in cats by clipping the middle cerebral artety and removing the clip. Tha results indicated that after 5 hrs of ischemia, the ?CBF decreased from 106?12ml/100g/min to 17?4ml/ 100g/min (P

Tupaiidae has been considered as low primate by most scholars. Focal cerebral ischemia study on tupaiidae has not been reported. Acute focal cerebral ischemic model in tupaiidae was produced by cauterizing the middle cerebral artery. The results indicated that after 15 minutes and 6 hrs occlusion of the middle cerebral artery, the rCBF's in the ischemic cortex were reduced respectively to 36.7% and 39.8% of those before occlusion, and the amplitudes of SFP to 21.83% and 36.78%. After 6 hrs of ischemia, a decrease in ATP content to 5.2 times that of the control, and an increase in AMP to 4.4 times were measured. Calcium and MDA contents in ischemic cerebral cortex increased (P

After 45 min ligation of the gerbils' bilateral carotid arteries and then 24h reperfusion,the effects of water soluble Pollen flavone element from buckwheat, Isocorydine on the stroke index of 45 min cerebral ischemia followed by reperfusion 6h and the mortality of reperfusion 24h were evaluated .The results indicated that pollen element from buckwheat could decrease the stroke index and mortality rate dramatically, while Isocorydine had no effects.It was speculated that the beneficial effects of pollen element from buckwheat on cerebral damage following ischemia with reperfusion might be due to its depressing effect on the metabolism of free radicals.

By 45 min ligation of the gerbils' bilateral carotid arteries and then 24h reperfusion, the effects of panax notogniseng saponins ( PNS ) and SOD on the stroke index of 45 min cerebral ischemia followed by reperfusion 24h were evaluated. The results indicated that PNS and SOD could decrease the stroke index and mortality dramatically.We speculated that the beneficial effect of PNS on cerebral damage folio-wing ischemia with reperfusion might be due to anti-free radical action. The effects of PNS, Rb1 Rg1 and nimodi-pine on focal cerebral ischemia were studied by 12h occlusion of middle cerebral artery in squirrel monkeys. Both Rb1 and nimodipi-ne alleviated the brain edema and calcium content in ischemic tissue significantly, and reduced the infarcted size, while the effect of Rg1 was not statistical. The results suggested that the anti-cerebral ischemia effect of Saponin Rb1 probably contributes to its calcium antagonism.

Acute in-complete cerebral ischemia were induced in 39 rabbits by hypotension coupled with hypoperfusion for 60 min, and acute forebrain ischemia were induced in other 15 rabbits by 4A-Occlus-ion for 30 min followed by reperfusion 120 min. At the end of experiment, EEG, the tissue contents of sodium,potassium and water in the cerebral cortex, the activities of LDH and CPK in the cerebral venous blood and the maximal bleeding volume were estimated. Sanchinoside D1 ( 50mg/kg, i.v.) could ameliorate significantly all the changes of relevant parameters mentioned above in model animals. It was suggested that Sanchinoside D1 had some protective effect on acute cerebral ischemia in rabbits

Objective: To explore the current status of knowledge, attitudes and practices (KAP) regarding tuberculosis(TB)prevention and control among high school students, and to compare differences between male and female students, so as to provide a scientific basis for targeted TB prevention and control measures in high schools. Methods: From April to May 2024, a stratified cluster random sampling method was employed to conduct an electronic questionnaire survey among 1 912 students from 10 high schools using a compiled questionnaire on KAP towards TB prevention and control. The AMOS 26.0 software was utilized to construct structural equation modeling (SEM) and compared the difference among genders. Results: The overall awareness rate of core TB knowledge among high school students in Gongshu District was 76.62%. Additionally, core knowledge about TB (6.28±1.44), prevention attitudes (6.02±1.84), and prevention practices (6.38±2.11) scores of female students were higher than those of male students (5.96±1.74, 5.59±2.21, 6.15±2.23) ( t =4.31, 4.64, 2.25, P <0.05). The SEM showed that knowledge had a strong positive impact on practices and attitudes among boys, with total effect values of 0.963 and 0.819 , respectively; while the positive influence of attitudes on practices was relatively weak, with a total effect value of 0.186. Among girls, attitudes had a positive impact on practices and knowledge, with total effect values of 0.479 and 0.222, respectively. Conclusions The pathways and strengths of influence of KAP in the SEM of TB prevention and control differ between male and female high school students. Therefore, differentiated strategies should be implemented for TB health education targeting male and female high school students.