4.Preliminary results of intraoperative radiation therapy for cervical carcinomaⅡb
Chinese Journal of Obstetrics and Gynecology 2000;0(09):-
0.05). However, there were quite improvements of survival rate and survival quality for cervical adenocacinoma. Their 5-year survival rates were 91% and 33% (P
5.Effectiveness of integrative medicine for preventing postoperative recurrence of primary hepatic carcinomas: a systematic review.
Zi-yao CHEN ; Jian LIANG ; Xin DENG
Chinese Journal of Integrated Traditional and Western Medicine 2014;34(6):671-675
OBJECTIVETo systematically evaluate the effectiveness of integrative medicine (IM) for preventing postoperative recurrence of primary hepatic carcinomas (PHC).
METHODSSuch databases as The Cochrane Library, PubMed, EMbase, China National Knowledge Infrastructure (CNKI), VIP Database, Wan-fang Database were retrieved to collect randomized controlled trials (RCTs) on preventing postoperative recurrence of PHC by IM. The retrieval period started from database establishment to June 2013. Literature screening, data extraction, and quality evaluation were performed by two reviewers strictly according to inclusion criteria. Meta-analysis was conducted using RevMan 5.2 Software.
RESULTSA total of 5 RCTs involving 367 patient cases were included. Results of Meta-analysis showed that the IM group was superior to the Western medicine (WM) group in the 1-, 2-, and 3-year recurrence rates (P < 0.05).
CONCLUSIONIn the prevention of postoperative recurrence of PHC, the effectiveness of IM was more significant, when compared with treatment of Western medicine.
Drugs, Chinese Herbal ; therapeutic use ; Humans ; Integrative Medicine ; Liver Neoplasms ; prevention & control ; Neoplasm Recurrence, Local ; prevention & control ; Postoperative Period ; Randomized Controlled Trials as Topic ; Treatment Outcome
8.Correlation between integrated pharmacokinetics and pharmacodynamics of bile processed Rhizoma Coptidis in febrile rats.
Jing WANG ; Yue CHEN ; Zi-min YUAN
Acta Pharmaceutica Sinica 2016;51(1):127-131
This study was designed to validate the correlation between integrated pharmacokinetic and therapeutic effects of alkaloids using bile processed Rhizoma Coptidis (BRC). Rats were divided into three groups: normal, disease model, model+BRC. Rats were induced to have an excessive heat syndrome. Rectal temperatures were collected at 0, 3, 6 and 9 h after single oral administration of the drugs. The plasma concentrations of three alkaloids were quantified at different times by UPLC-MS/MS after the administration of BRC. An approach of self-defined weighting coefficiency was created to the holistic pharmacokinetic profiles of alkaloids in BRC. The classified and integrated synthetic concentrations were obtained, and then the pharmacokinetic parameters of alkaloids were calculated from non-compartmental model analysis. The potential relationship between the integrated mean concentration of alkaloids and the antifebrile efficacy was investigated. The holistic t(max) of alkaloids was 1.11 h, the antifebrile effect of BRC at 3 h was improved over the model group. Double peaking appeared in the integrated blood concentration-time curve, the second t(max) of alkaloids was 4.82 h. The antifebrile effects of BRC at 3-6 h were significant, and the antifebrile effects at 6-9 h was decreased significantly. Dynamic variation of alkaloids of BRC in the body exhibited the similarity to the pattern of its antifebrile effect.
Administration, Oral
;
Alkaloids
;
pharmacokinetics
;
Animals
;
Bile
;
Coptis
;
chemistry
;
Drugs, Chinese Herbal
;
chemistry
;
pharmacokinetics
;
Rats
;
Rats, Sprague-Dawley
;
Rhizome
;
chemistry
;
Tandem Mass Spectrometry
9.Effect of symptoms of posttraumatic stress disorder on the psychological states among high school students in the earthquake regions
Zi CHEN ; Min SHEN ; Yanzhang LI
Chinese Journal of Behavioral Medicine and Brain Science 2014;23(2):152-155
Objective To investigate the effect of posttraumatic stress disorder(PTSD) on the psychological healthy state among high school students in the earthquake regions.Method The samples were consisted of 666 high school students who had experienced the Wenchuan Earthquake.The Impact of Event Scale-Revised (IES-R) and Self Description Questionnaire (SDQ) were used to rate symptoms of PTSD and psychological states of high school students.Data were analyzed using correlation analysis and structural equation model analysis for male or female separately.Results (1) Because their scores of IES-R were higher than 35,22.67% participants were considered as PTSD patients,girls accounted for 83 or 25.31% of the total female;and boys accounted for 68 or 21.72% of the total male.(2) Among female,avoid and awake systems of PTSD were correlated significantly with their psychological state significantly (r=0.101-0.181,P<0.05).The result of structural equation model analysis was similar to correlation analysis,corresponding coefficients of path ranged 0.11 to 0.18 (P<0.05).(3) Among male,intrude and awake systems were correlated with their psychological state significantly (r=0.111-0.313,P<0.05).Corresponding coefficients of path ranged from 0.11 to 0.31 (P< 0.05).Conclusion Systems of PTSD effect clearly on the psychological state of high school students,and there are the gender difference among these relationships.The symptoms of PTSD influence interpersonal relationships,emotion,conduct,appearance and self-evaluation,but school work and stamina are not influenced in this study.
10.Study on the short version of the BFS mood scale and its reliability and validity
Jinjin GAO ; Fei ZI ; Yiwen CHEN
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(4):373-375
ObjectiveTo provide a brief scale of mood measurement with satisfactory reliability and validity.MethodsThe 40-item BFS was abbreviated to a short-vcrsioncd BFS by item analysis.282 adult participants were surveyed by the brief BFS and NEO-FFI while NEO-FFI was taken as a criterion instrument.Reliability and validity of brief BFS were examined.ResultsThe brief BFS had 18 items including six dimensions ( activity,cheer,calmness,indignation,stir and depression),and the cronbach's α were 0.87,0.75,0.85,0.86,0.84 and 0.86 respectively and the retest reliability( r value) were 0.67,0.57,0.61,0.62,0.75 and 0.69 respectively.All the key fit indices of confirmatory factor analysis (CFA) of brief BFS were above 0.90.Besides,NEO-FFI had significant correlation with brief BFS.ConclusionThe brief BFS has satisfactory reliability and validity.