1.Advanced development of dendritic cell and leukemia
Journal of Leukemia & Lymphoma 2009;18(2):123-127
Dendritic cells are the most powerful cells to induce T cell immune reaction. DC derived from leukemia also possess the ability of the antigen processing and presentation. DC pulsed with tumor antigen can effectively initiate T cell immune reaction and induce T cell to cytotoxic T lymphocytes in vitro and in vivo. In this text, we introduce the advanced development of the biological character of DC, tumor immunology, the mechanism of tumor cell escaping immune surveillance and DC in leukemia immunotherapy.
3. Evaluation of Guinea pig skin infection model of Trichophyton rubrum based on analytic hierarchy process
Chinese Pharmacological Bulletin 2019;35(9):1325-1331
To establish the evaluation system for Guinea pig skin infection model of Trichophyton rubrum, and to evaluate different modeling methods and select the best skin infection animal model of Trichophyton rubrum. Methods The evaluation index was determined by literature research and expert consultation , weight of each index was calculated by Delphi Method and the analytic hierarchy process (AHP), to establish a comprehensive evaluation system for Guinea pig skin infection model of Trichophyton rubrum. Furthermore, various skin infection animal models of Trichophyton rubrum were evaluated by this system and the ideal animal model was selected. Results The evaluation system proved to be available. The animal model with immunosuppressive treatment and repeated inoculation with Trichophyton rubrum had better quality and higher success rate. Conclusions The evaluation system established by AHP is clear, simple and convenient; the optimized skin infection animal model of Trichophyton rubrum is suitable for the efficacy evaluation of antifungal infection drugs.
7.Progress in researches on L-asparaginase targeted to childhood leukemia.
Yan-qin CUI ; Fu-xiong CHEN ; Zi-liang WU
Chinese Journal of Pediatrics 2004;42(3):227-230
Antineoplastic Agents
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administration & dosage
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adverse effects
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therapeutic use
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Asparaginase
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administration & dosage
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adverse effects
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therapeutic use
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Child
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Drug Administration Routes
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Drug Administration Schedule
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Forecasting
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Humans
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Leukemia
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drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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drug therapy
10.Study on the Fermentation Condition of Steroid 15?-Hydroxylation by Penicillium raistrickii
Jun LI ; Xu GENG ; Liang WENG ; Zi-Rong WU ;
Microbiology 1992;0(05):-
The fermentation conditions which affect C-15? hydroxylation o f 18-methyl-estr- 4-ene-3,17-dione were investigated. As the key step in the Hydroxylation, the dissolution of substrate was focused on. Tween80, MeOH, DMSO,?-CD and 2-HP?CD were studied to improve the dissolvability of 18-met hyl-estr-4-ene-3,17-dione.The other factors such as pH, substrate concent ration and aeration strategies which affected conversion rate were also resea rched. As a result, the conversion rate can be up to 60% in shake flask and ach i(eve 50% in fermentor,which would overcome the disadvantage of 15?-hydroxyl -18-methyl-estr-4-ene-3,17-dione chemosynthesis and provide a good techn ics to industry.