OBJECTIVE To diminish and discontinue intra-hospital cross infection in Disinfection Supplier Centre.METHODS The administration of personal resources control was developed,the equipment and systemic control of aseptic process and isolation was reasonably arranged,and the quality control was enhanced.We executed the routine seriously during our daily work,and gave strict measures during quality management such as disposal,classification,washing,disinfection,packaging,sterilization,monitoring,stockpile,and handout.RESULTS Every criterion of aseptic and isolation work were all adapted to the demanding set up by Ministry of Health referred to hospital infection control quality standard,The infection control in our Centre was standardized and regular scientific channel was set up.CONCLUSIONS Quality administration care can play a main and key role in the control of cross hospital infection in Disinfection Supplier Centre.