1.Transplantation of bone marrow cells up-regulated the expressions of HSP32 and HSP70 in the acute ischemic myocardium
Shaoheng ZHANG ; Jingxuan GUO ; Ping ZHANG ; Yonggang LIU ; Zhuqing JIA ; Xinheng FENG ; Zhaoping LI ; Weihong LI ; Kangtao MA ; Chunyan ZHOU ; Lingson LI
Journal of Peking University(Health Sciences) 2003;0(05):-
Objective:To clarify the role of Heat shock proteins (HSPs) on the cardiac function during acute myocardial infarction (AMI) after bone marrow cell implantation (BMT), we examined the expression of HSP32 and HSP70 in a rat model of myocardial infarction. Methods: Myocardial infarction model was induced in the inbred Lewis rats by left anterior descending artery ligation,and 5?10 6 of bone marrow mononuclear cells (BM MNCs) were injected into an ischemic zone. On days 1, 3, 7 and 14 post infarct, the differentiations of transplanted cells and the expressions of HSP32 and HSP70 were determined by immunofluorescence or RT-PCR. The cardiac function was evaluated by echocardiography. Results: Immunofluorescence microscopy of hearts from BMT group revealed that expressions of HSP32 and HSP70 were promoted within cardiomyocytes in the infarction zone and the peri infarct zone,and expressed within some transplanted bone marrow cells as well. RT-PCR also showed the mRNA expression levels of HSP32 and HSP70 in BMT group were significantly higher than those of the control group, peaked on day 3 post infarct (5.0 fold and 2.9 fold, respectively, P
2.Effect of continuous nursing intervention in tumor patients with PICC
Xiaoyan JIA ; Yi ZHAO ; Zhuqing ZHANG ; Haihua CHEN
Journal of Clinical Medicine in Practice 2015;(8):37-39,55
Objective To explore the effect of continuous nursing intervention in tumor pa-tients with PICC.Methods A total of 116 hospitalized tumor patients with PICC from March 2012 to February 2013 were in the observation group and 102 tumor patients with PICC from Jan-uary 2011 to February 2012 were in the control group.The two groups were both given conven-tional nursing and the observation group was given continuous nursing intervention by continuous nursing team after discharged from the hospital on the basis of conventional nursing.The complica-tions and command condition of PICC related knowledge in the two groups were compared,and consultation patients and their families and settlement conditions in the observation group were cal-culated.Results The differences in incidence rate of complications and PICC command condition of related knowledge were statistically significant (P <0.05).Patients and their families in the ob-servation group consulted 1048 questions and 1037 cases were effectively solved,effective solving rate was 98.95%.Conclusion Continuous nursing intervention can improve PICC related knowl-edge and skills in patients and their families and can reduce the incidence of complications.So it is worthy of application.
3.Effect of continuous nursing intervention in tumor patients with PICC
Xiaoyan JIA ; Yi ZHAO ; Zhuqing ZHANG ; Haihua CHEN
Journal of Clinical Medicine in Practice 2015;(8):37-39,55
Objective To explore the effect of continuous nursing intervention in tumor pa-tients with PICC.Methods A total of 116 hospitalized tumor patients with PICC from March 2012 to February 2013 were in the observation group and 102 tumor patients with PICC from Jan-uary 2011 to February 2012 were in the control group.The two groups were both given conven-tional nursing and the observation group was given continuous nursing intervention by continuous nursing team after discharged from the hospital on the basis of conventional nursing.The complica-tions and command condition of PICC related knowledge in the two groups were compared,and consultation patients and their families and settlement conditions in the observation group were cal-culated.Results The differences in incidence rate of complications and PICC command condition of related knowledge were statistically significant (P <0.05).Patients and their families in the ob-servation group consulted 1048 questions and 1037 cases were effectively solved,effective solving rate was 98.95%.Conclusion Continuous nursing intervention can improve PICC related knowl-edge and skills in patients and their families and can reduce the incidence of complications.So it is worthy of application.