Objective:To discuss the distinctive clinical manifestation of primary aspergillus laryngitis.Method:Six cases of primary aspergillus laryngitis in our department were reviewed,among which 3 cases were diabetes patients,and were laryngeal mucosal barrier impairment.2 cases were smoking, 2 cases were over use of voice and 1 case were gastro-pharyngeal reflux . Refractory hoarseness was the main clinical manifestation of all patients. The prophase treatment with antibiotics and glucocorticoid should breakdown the balance of flora and exacerbate the disease.Result:Stop using antibiotics and glucocorticoid and alter to oral administration of itraconazole in 2 to 4 weeks after final diagnosis can effectively cure the disease. No recurrence was found in 6 month to 4 years follow up.Conclusion:Diffuse hyperemia ,pachynsis and scattered lamellar leukasmus of vocal cord were the characteristic physical findings of primary aspergillus laryngitis.Pathology is the major means to get the final diagnosis. Oral administration of itraconazole could be effective.

OBJECTIVE: To discuss the distinctive clinical manifestation of primary aspergillus laryngitis. METHOD: Six cases of primary aspergillus laryngitis in our department were reviewed, among which 3 cases were diabetes patients, and were laryngeal mucosal barrier impairment. 2 cases were smoking, 2 cases were over use of voice and 1 case was gastro-pharyngeal reflux. Refractory hoarseness was the main clinical manifestation of all patients. The prophase treatment with antibiotics and glucocorticoid should breakdown the balance of flora and exacerbate the disease. RESULT: Stop using antibiotics and glucocorticoid and alter to oral administration of itraconazole in 2 to 4 weeks after final diagnosis can effectively cure the disease. No recurrence was found in 6 month to 4 years follow up. CONCLUSION Diffuse hyperemia, pachynsis and scattered lamellar leukasmus of vocal cord were the characteristic physical findings of primary aspergillus laryngitis. Pathology is the major means to get the final diagnosis. Oral administration of itraconazole could be effective.
Adult ; Aged ; Antifungal Agents ; therapeutic use ; Aspergillosis ; diagnosis ; drug therapy ; Aspergillus ; Female ; Humans ; Itraconazole ; therapeutic use ; Laryngitis ; diagnosis ; drug therapy ; microbiology ; Male ; Middle Aged ; Retrospective Studies ; Young Adult