Pediatric venous thromboembolism is a life-threatening disease caused by many factors,of which the central venous catheter is the first high-risk factor,and the clinical presentation varies according to the position of obstruction.Color Doppler ultrasound,CT scan,MRI are the major diagnostic techniques.Low-molecular-weight heparin combines with oral anticoagulant agent are commonly used in therapy and prophylaxis.Early diagnosis and prevention are beneficial to the survival rate.

Thrombelastography(TEG) is a convenient,rapid test of coagulation.It records the continuous profiles of whole blood coagulation by measureing the viscoelastic changes of blood clot.Compared with conventional test of coagulation,TEG reflects the function of platelet,coagulation factors and fibrinolysis more comprehensively and dynamically.The small volume of blood required and less time-consuming make it more suitble for children.This review focuses on the clinical value of TEG in the diagnosis of hemorrhagic disorders as well as the individualized treatment of cogulation disorders,disseminated intravascular coagulation and antiplatelet drugs.

OBJECTIVE:To investigate the stability of Yanhouyan mixture(for pharyngolaryngitis).METHODS: The st-ability of Yanhouyan mixture was investigated by classic constant temperature accelerated test method and sample observation method taking the content of Baicalin as index which was determined by HPLC.RESULTS:The content change of Bacilin in Yanghouyan mixture was in line with the first order kinetics,and the test results for both methods were similar.Under room temperature(25 ℃),the validity duration of Yanhouyan mixture was 1.06 years.CONCLUSION:In establishing the quality standard for Yanhouyan mixture,the advisable storage life of 1 year for which should be considered.

OBJECTIVE: To establish the method for the determination of diosgenin in Di’ ao Xinxuekang Capsule by HP_LC. METHOD: The condition of HPLC was Shim-pack CLC-Sil columm ( 150mm? 6. 0mm) , mobile phase of 2. 0% isopropand in petroleum ether and UV detector at 206nm. RESULTS : The method proved to be linear in the range at 0. 58～ 11. 6? g of diosgenin with correlation coefficient of 0. 999 8. The linear formula was Y=3. 682? 107X+ 1700, The average recovery and recision were 99. 49% , and RSD=0. 12% ( n=5) . CONCLUSION: The method is simple, accurate, specific and can be used to the quality control of the preparation.

On March 11, 2011 eastern Japan was struck by magnitude 9.0 earthquake and an enormous tsunami which together killed over 20,500 people and resulted in the evacuation of over 320,000 people from the devastated areas. This paper introduces the damage sustained by the Fukushima-Daiichi nuclear power plant during this major natural disaster, as well as the protection of the public protection measures;nuclear accident in Fukushima is worth pondering for future energy development planning and response in Japan and around the world.

Objective To explore the immunosuppressive effect of XGD 1 and its mechanism. Methods Different concentrations of XGD 1 were added to PHA or ConA induced human peripheral blood T lymphocyte.Seventy two hours later modified MTT assay was employed to test the effect of XGD 1 on T cell proliferation. Flowcytometry was used to examine the effect of XGD 1 on the expression of IL 2 receptor(IL 2R) on the surface of T cells individually at 48 h and 72 h.And the effects of XGD 1 combined with cyclosporine A(CsA) on the proliferation of T lymphocytes and the expression of IL 2R were also investigated. Results In the concentration range of 0.2～25 ?g/ml,XGD 1 exerted marked inhibitory effect on PHA or ConA induced T cell proliferation,which was proportional to dose. Flowcytometry showed that XGD 1 inhibited the expression of IL 2R,and the percentage of IL 2R? positive cells after stimulation of PHA decreased from 47.67% to 25.03% in the presence of XGD 1 (1 ?g/ml).XGD 1 and CsA had synergism in inhibition of T cell proliferation and IL 2R expression. Conclusion The study suggests that XGD 1 has immunosuppressive effect. The suppressive effect of XGD 1 on T cell proliferation is most probably mediated by decreasing IL 2R expression.

Pectus excavatum and carinatum are the most common deformity of chest wall deformity.To get anatomical deformity correction,beautify,improve physical function and the quality of life are the therapeutic purposes.Among the various clinical research and treatment,non-invasive treatment,which is the trend,is popular in surgeons and patients as well.From clinical experience,combining international and domestic progress of treatment on chest wall deformity,this review discuss the application prospect of non-invasive treatment.

Objective To compare the efficacy and toxicity of SOX and FOLFOX4 regimen in the treatment of advanced gastric cancer.Methods Total of 32 patients with advanced gastric cancer proved pathologically were randomly divided into 2 groups:16 patients received SOX regimen [oxaliplatin 130 mg/m2 as a 2-hour infusion on day 1,S-1 capsules 80 mg/(m-2·d) twice a day per oral from day 1 to day 14 every 3 weeks],the other 16 patients received FOLFOX4 regimen [oxaliplatin 85 mg/m2 as a 2-hour infusion on day 1 and a 2-hour infusion of LV 200/(m2· d) followed by a 5-Fu bolus 400/(m2· d) and 22-hour infusion 600/(m2· d) for 2 consecutive days every 2 weeks].Efficacy was evaluated at least 2 cycles.Results The response rates of SOX group and FOLFOX4 group were 56.25 ％ (9/16) and 43.57 ％ (7/16),the disease control rates were 81.25 ％ (13/16) and 75.00 ％ (12/16).The median progress free survival times were 7.2 months and 5.6 months,the median overall survival times were 9.4 months and 7.9 months.The main toxicity in the two groups was hematological toxicity,nausea/vomiting,and peripheral neuropathy.The main grade 3 hematologic toxicity was neutropenia,with no significant difference between them [12.50 ％ (2/16) vs 31.25 ％ (5/16),P =0.394].Conclusions Both SOX and FOLFOX4 regimens are effective for patients with advanced gastric cancer.Compared with FOLFOX4 regimen,SOX regimen is better tolerated for advanced gastric cancer with longer progress free survival and overall survival.

Juvenile retinoschisis (RS or XLRS,MIM#312700)is a rare X-linked inherited disorder,mainly affects bilateral retina,and is characterized by cartwheel-like changes of the macular region of the retina and schisis or splitting within the inner retinal layers,leading to visual deterioration.The electroretinogram is beneficial in the diagnosis of juvenile retinoschisis.The a-wave can be of normal or nearly normal amplitude in this disorder,whereas the amplitude of the b-wave is appreciably reduced,giving a decrease in the proportion of b/a.The responsible gene,XLRSl,maps to Xp22 and was identified by positional cloning.This paper makes a brief review about the latest XLRS research of pathogenesis,animal experiments,clinical therapy,and 25 references are cited.