Objective To explore the levels of serum interleukin-6 and interleukin-18 in newly diagnosed type 2 diabetes mellitus (T2DM) and investigate their roles. Methods The serum interleukin-6 and interleukin-18 levels were detected in 50 newly, diagnosed T2DM patients (T2DM group) and 40 normal subjects (control group). Fasting blood glucose, fasting insulin, blood lipid, body mass index (BMI) and waist/hip ratio (WHR) were measured. HOMA-IR and HOMA-β were calculated. Results The serum interleukin-6 and interleukin-18 levels in T2DM group were significantly higher than those in control group [(2.56 ± 1.09) ng/L vs (1.81±0.80) ng/L, (5.38±0.91) ng/L vs (4.62±0.59)ng/L] (P <0.01).Interleukin-6 level was positively correlated with HbA_1c,while interleukin-18 level was positively correlated with BMI and WHR. Interleukin-6 and interleukin-18 levels were positively correlated. Interleukin-6 and interhukin-18 could predicted the insulin resistance. Conclusion Interleukin-6 and interleukin-18 take part in the development of T2DM, and can be related to the insulin resistance.

Observation was made on the changes of exfoliative tongue cells before and after treatment in 49 cases of massive and dribbling ulterine bleeding. Meanwhile, the mature index of vaginal exfoliative cells was also e-valuated. Results showed that all the exfoliative cells from both were regulated by female sex hormQne with synchronous changing rules.

Insulin resistance is the important base of the pathogenesis of type 2 diabetes.Physical exercise can improve insulin sensitivity.This article presents an overview of how physical exercise improves insulin resistance and helps the prevention and treatment of diabetes mellitus by analyzing its influence on the level of insulin receptor and post-receptor and adipose cell cytokine.

BACKGROUND:Compared with the titanium with smooth surface, TiO2 nanotubes are more beneficial for the early cel adhesion. OBJECTIVE:To review the research progress of the effect of TiO2 nanotubes on peri-implant cel s. METHODS:A computer-based retrieval of CNKI, CqVip, WanFang and PubMed databases was performed for pertinent literatures published between 1990 to 2016, using the Chinese keywords of“TiO2 nanotubes or titanium dioxide nanotubes and implant”, and English keywords of“TiO2 nanotubes implant, Tio2 nanotubes cel”. RESULTS AND CONCLUSION:The main factors that TiO2 nanotubes affect the peri-implant cel behaviors include the tubular morphology, size, TiO2 crystal structure, as wel as surface chemical compositions, roughness and hydrophilicity and free energy. The influence factors of TiO2 nanotubes for cel s are not only related to the tube diameter, but also associated with cel types. Different cel types hold different diameters suitable for the cel adhesion, proliferation and differentiation on the material surface. Therefore, it is advisable to select the best nanotube size for different tissues and cel s applied in different biomedical fields.

Diabetes Complications ; drug therapy ; surgery ; therapy ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Ischemia ; drug therapy ; etiology ; surgery ; therapy ; Lower Extremity ; blood supply

Objective To explore the effect of controlled premature delivery and its termination method of pregnancy.Methods The clinical data of 151 cascs of controlled premature delivery were retrospectively analyzed.Results The incidence of premature delivery was 7.5% and the incidence of controlled premature delivery was 44.8%.The cesaran section rate of controlled premature delivery Was 93.4%.Pregnancy induced hypertension(PIH)was the first place reason of controlled premature delivery.The second was antepartum hemorrhage,intrauterine fatal diatress and placenta previa,pregnancy associated with cardiac disease.The complications and mortality of premature infants were reduced if antenatal care is regularly and glucocorticoids could be used.Conclusion Antenatal care and proper treatment can increase the survival rate of premature infants in the inevitable controlled delivery.

Animals ; Corticosterone ; pharmacology ; Hippocampus ; drug effects ; physiology ; In Vitro Techniques ; Long-Term Potentiation ; drug effects ; physiology ; Male ; Rats ; Rats, Wistar

1∶2,inspiratory press

Objective To evaluate the the brow position and shape in young Chinese women using a photography measurement.Methods A total of 100 Chinese women aged 20 to 30 years were photographed to determine the distance between brow and eye.Measurements were made from a horizontal plane through the lateral canthus of right eye to three vertical points on the upper brow margin at the medial canthus,lateral limbus of the iris,and lateral canthus.Results The distance between brow and eye in young Chinese women was 2.12,2.52 and 2.46 cm at medial canthus,lateral limbus of the iris and lateral canthus,respectively.The distances were higher between the brows and eyes at lateral limbus of the iris and lateral canthus than that at medial canthus (P＜0.05).Conclusions The measurement used in this study is a simple and practical quantitative method.The results can be used to guide the surgical choice and help to evaluate the surgical techniques.

OBJECTIVE:To investigate the profitability of listed pharmaceutical enterprises in China,and to investigate the ba-sic profitability path. METHODS:With the help of DuPont financial analysis system,the financial data of the listed companies and other manufacturing industry during 2007-2013 were collected and compared in terms of the return on equity(ROE),profit margin (PM),asset turnover (ATO) and equity multiplier (EM),etc. RESULTS & CONCLUSIONS:During 2007-2013,average ROE and PM of listed pharmaceutical companies both were higher than those of other manufacturing industry(10.00% vs. 6.40%, 11.50% vs. 6.49%);while average ATO and EM were lower than other manufacturing industry (0.65 vs. 0.73,1.90 vs. 2.19), with statistical significance(P<0.05). It has advantages in core earnings and product profitability while disadvantage in asset turn-over and financial leverage for the listed pharmaceutical companies. Listed pharmaceutical companies’gross margin was higher (42.87% vs. 22.07%),but was offset by the higher ratio of expenses to sales(18.24% vs. 5.61%)and insufficient utilization ratio of circulating assets. To change this situation,listed pharmaceutical enterprises should focus on circulation cost saving and the im-provement of assets operation ability,especially enhancing the utilization ratio of current assets.