Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

Objective To analyze the characteristics and therapeutic effects in the elderly patients with acute eholangitis of severe type(ACST) Methods The clinical data of 60 cases of elderly patients with ACST. Results The cured 44 cases(73.3% )and 16 deaths(26.7% ) ,the cause of death:septic shock four cases (25.0%) ,3 cases of acute renal failure(18.8%) ,ARDS four cases(25.0% ) ,multi - organ failure five cases(31.3% ). Incidence surgery within 24 h the deaths of three cases( 18.8% ) ,significantly less than 24 h after surgery incidence death in 13 cases (81.3%) ( X2= 7.72, P<0.01 );correct preoperative shock has been 40 cases, six cases of death ( 15.0% ) was significantly lower than the preoperative shock not corrected in 20 cases,death in 10 patients(50.0% ) ( X2=6.75 ,P <0.01 ). Conclusion The cure rate was improved from early diagnosis and perioperative management in the elderly patients with acute cholangitis of severe type.

The rapid progress in surgery in China has been closely related to government investment in public health care, construction of medical talents team, and basic and clinical research. The achievements of bench studies promote the development of clinical surgery. Translational medicine (bench-bedside-bench) has gained much attention in the medical community. The driving force promoting long-term development of surgery in China includes collaboration of basic scientists and surgeons, cultivation of surgeons with aptitude in scientific research, initiation of clinical research and popularization of multidisciplinary team.
Biomedical Research ; China ; General Surgery ; Humans

Gastric cancer remains one of the most common causes of cancer-related death in China. Radical operation is the only potentially curative therapy for advanced gastric cancer (AGC). D2 radical gastrectomy has been widely accepted as a standard surgical procedure for patients with AGC in China. Several clinical trials have revealed that more extended resection than D2 surgery has no impact on survival. In order to improve the prognosis of AGC patients, it is necessary to carry out the preoperative TNM staging for selecting a reasonable therapeutical modality before surgery. Multimodality treatment involving perioperative chemotherapy, radiotherapy or molecular targeting agents in addition to surgery have been thought to be promising treatment strategy. In this article, we present an update on the current literature regarding the trends of surgical multimodal treatment for the patients with AGC.
Combined Modality Therapy ; trends ; Humans ; Stomach Neoplasms ; surgery

Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

Objective To report the first case of ectodermal dysplasia/skin fragility syndrome in China. Methods The clinical data, transmission electron microscopic examination and immunohistochemical analysis of this patient were evaluated. Results The patient was a 3-year-old girl who presented increased skin fragility with trauma-induced, blisters and erosions, combined with short and sparse hair, finger-and toe-nail dystrophy and palmoplantar keratoderma. Transmission electron microscopy showed a loss of keratinocyte-keratinocyte adhesion, widening of intercellular spaces and a reduced number of hypoplastic desmosomes. Immunohistochemical analysis revealed a complete absence of staining for plakophilin 1. Conclusion Ectodermal dysplasia/skin fragility syndrome is a rare autosomal recessive inherited disease characterized by clinical manifestations as well as electron microscopic features and immunohistochemical evidence.

OBJECTIVE:To evaluate the status quo and the developmental trend of the application of antidepressant drugs in our hospital.METHODS:The antidepressant drugs in our hospital during2002～2004were analyzed retrospectively in terms of drug varieties,consumption quantity,consumption sum,DDDs etc.RESULTS:The consumption sum of the antidepressant drugs increased year by year,which stood at667.41,802.47and995.02(RMB:ten thousand yuan),respectively in the3years.CONCLUSION:Fluoxetine dominates the first place in terms of clinical application of antidepressants.Furthermore,the application of new type antidepresants has been on the rise.

Wnt signal transduction pathway plays a very important role in embryonic development, and its abnormality may lead to developmental defects and cellular malignant transformation. It has been shown that disturbances of the Wnt signal transduction pathway were significantly related to human neoplastic transformation. The core mechanism of the pathway abnormality was the accumulation of free ?-catenin protein in the cytoplasm and nucleus resulting in the expressions of specific target genes by downstream pathway. This paper reviews the composition and structural character, transduction and regulation of the Wnt signal pathway and its relation with human tumorigenesis.

Objective To investigate the therapeutic effect of Qingyan Mixture for laryngeal cough patients with lung dryness due to yin deficiency. Methods Sixty laryngeal cough patients with lung dryness due to yin deficiency were evenly randomized into treatment group and control group. The treatment group was given oral use of Qingyan Mixture, and the control group was given oral use of Ketotifen and Carbetapentane. The course of treatment for both groups lasted for 10 days. The overall therapeutic effect, and the effect on individual symptom or sign were evaluated after treatment. Results ( 1) In the treatment group, six patients were cured, 14 were markedly effective, 8 were improved, 2 were ineffective and the total effective rate was 93.3%. In the control group, one case was cured, 7 were markedly effective, 17 were improved, 5 were ineffective and the total effective rate was 83.3%. The overall clinical effect in the treatment group was significantly higher than that in the control group (P<0.01) . (2) As for the effect on individual symptom or sign, the treatment group showed stronger effect on dry cough than the control group ( P<0.01) , while differences of dry pharynx, throat itching, foreign body sensation in the throat, and pharyngeal signs were insignificant between the two groups (P>0.05) . (3) After treatment, the total scores of main symptoms were decreased in both groups (P<0.05 or P<0.01) compared with those before treatment. Conclusion Qingyan Mixture shows certain effect on relieving symptoms and signs of laryngeal cough patients with lung dryness due to yin deficiency.

Hypoxic pulmonary hypertension(HPH) is a common disease featured by acute hypoxic pulmonary vasoconstriction(HPV) and chronic hypoxic pulmonary vascular remolding(HPVR) leading to the sustained increasing of pulmonary artery pressure.There are many mediators involved in the HPH but none can illustrate it successfully.Primary work has found 15-lipoxygenase(15-LO) and its catalyzed production 15-hydroxyeicosatetraenoic acid(15-HETE)(from arachidonic acid) are up-regulated in pulmonary vascular when exprosed to hypoxia.And it has been found 15-LO/15-HETE involved in many processes of both the HPV and HPVR,indicating 15-LO/15-HETE may be an important mediator of HPH.Advances research on 15-LO/15-HETE may illustrate the mechanism of HPH,and will give some message in looking for a potential clinical target of HPH.