The rapid progress in surgery in China has been closely related to government investment in public health care, construction of medical talents team, and basic and clinical research. The achievements of bench studies promote the development of clinical surgery. Translational medicine (bench-bedside-bench) has gained much attention in the medical community. The driving force promoting long-term development of surgery in China includes collaboration of basic scientists and surgeons, cultivation of surgeons with aptitude in scientific research, initiation of clinical research and popularization of multidisciplinary team.
Biomedical Research ; China ; General Surgery ; Humans

Gastric cancer remains one of the most common causes of cancer-related death in China. Radical operation is the only potentially curative therapy for advanced gastric cancer (AGC). D2 radical gastrectomy has been widely accepted as a standard surgical procedure for patients with AGC in China. Several clinical trials have revealed that more extended resection than D2 surgery has no impact on survival. In order to improve the prognosis of AGC patients, it is necessary to carry out the preoperative TNM staging for selecting a reasonable therapeutical modality before surgery. Multimodality treatment involving perioperative chemotherapy, radiotherapy or molecular targeting agents in addition to surgery have been thought to be promising treatment strategy. In this article, we present an update on the current literature regarding the trends of surgical multimodal treatment for the patients with AGC.
Combined Modality Therapy ; trends ; Humans ; Stomach Neoplasms ; surgery

Hypoxic pulmonary hypertension(HPH) is a common disease featured by acute hypoxic pulmonary vasoconstriction(HPV) and chronic hypoxic pulmonary vascular remolding(HPVR) leading to the sustained increasing of pulmonary artery pressure.There are many mediators involved in the HPH but none can illustrate it successfully.Primary work has found 15-lipoxygenase(15-LO) and its catalyzed production 15-hydroxyeicosatetraenoic acid(15-HETE)(from arachidonic acid) are up-regulated in pulmonary vascular when exprosed to hypoxia.And it has been found 15-LO/15-HETE involved in many processes of both the HPV and HPVR,indicating 15-LO/15-HETE may be an important mediator of HPH.Advances research on 15-LO/15-HETE may illustrate the mechanism of HPH,and will give some message in looking for a potential clinical target of HPH.

Peripheral T-cell lymphoma (PTCL) is a highly specific and invasive non-Hodgkin's lymphoma derived from mature T-cells that leave the thymus.At present, the clinical progress in PTCLs is behind that in B-cell lymphomas, and the current treatments for PTCLs have low efficacy and poor overall prognosis.Therefore, there is currently still no standard treatment for PTCL.The efficacy of the conventional CHOP chemotherapy regimen is poor, and the value of radiotherapy in early-stage PTLC patients remains to be determined.Autologous hematopoietic stem cell transplantation is the top choice for consolidation treatment for high-risk patients, but the efficacy of novel drugs for PTCLs needs to be further confirmed.In addition, PET/CT plays a more important role in predicting the prognosis of PTCLs.

Objective To analyze the characteristics and therapeutic effects in the elderly patients with acute eholangitis of severe type(ACST) Methods The clinical data of 60 cases of elderly patients with ACST. Results The cured 44 cases(73.3% )and 16 deaths(26.7% ) ,the cause of death:septic shock four cases (25.0%) ,3 cases of acute renal failure(18.8%) ,ARDS four cases(25.0% ) ,multi - organ failure five cases(31.3% ). Incidence surgery within 24 h the deaths of three cases( 18.8% ) ,significantly less than 24 h after surgery incidence death in 13 cases (81.3%) ( X2= 7.72, P<0.01 );correct preoperative shock has been 40 cases, six cases of death ( 15.0% ) was significantly lower than the preoperative shock not corrected in 20 cases,death in 10 patients(50.0% ) ( X2=6.75 ,P <0.01 ). Conclusion The cure rate was improved from early diagnosis and perioperative management in the elderly patients with acute cholangitis of severe type.

Objective · To understand current smoking status and analyze its influencing factors among university students in Shanghai, and provide reference and guidance for further efforts of tobacco control in campus. Methods · A total of 4816 students from 19 col eges in Shanghai were selected by stratified multi-stage cluster sampling and the sample size in each part was decided by proportion of col eges and types of specialities. Self-administered questionnaire was conducted to understand the current tobacco use and its influencing factors were analyzed. Results · The overal smoking prevalence of col ege students in Shanghai was 5.80%. General y, smoking prevalence of junior col ege students was higher than that of undergraduates (11.27% vs 3.68%, P<0.05) and smoking prevalence of male students was higher than that of females (11.10% vs 0.95%, P<0.05). Nonsmokers endorsed higher awareness on the harm of smoking and second-hand smoking than smokers(P<0.01). Besides, nonsmokers had a more positive attitude towards tobacco control policy than smokers (P<0.01). Students who studied in the junior college, males, in the senior grade, majored in liberal arts, with higher monthly living expenses, held negative attitude in raising cigarette prices and supporting of establishing smoke-free campuses were more likely to be smokers. Conclusion · Tobacco use among university students in Shanghai deserves attention. It is necessary to carry out systematic and in-depth education to prevent and reduce smoking among the university students.

OBJECTIVE:To evaluate the efficacy and safety of telmisartan in the treatment of hypertension.METHODS:The efficacy and safety of telmisartan versus losartan in treating hypertension reported in 5 studies were comprehensively evaluated with the meta-analysis in homogeneity test and combined test.RESULTS:Of the five randomized controlled trials(RCT) in which 771 patients who met the inclusion criteria were included,two studies were of high methodological quality according to Jadad scale.Meta analysis indicated that there was statistical significance between telmisartan and losartan in effectiveness(OR=1.55,95% confidence interval(1.12,2.16),P0.05).CONCLUSION:The effectiveness of telmisartan in the treatment of hypertension is significantly higher than that of losartan;however,there is no signficant differce in safety between the two drugs.

OBJECTIVE:To evaluate the status quo and the developmental trend of the application of antidepressant drugs in our hospital.METHODS:The antidepressant drugs in our hospital during2002～2004were analyzed retrospectively in terms of drug varieties,consumption quantity,consumption sum,DDDs etc.RESULTS:The consumption sum of the antidepressant drugs increased year by year,which stood at667.41,802.47and995.02(RMB:ten thousand yuan),respectively in the3years.CONCLUSION:Fluoxetine dominates the first place in terms of clinical application of antidepressants.Furthermore,the application of new type antidepresants has been on the rise.

Objective To report the first case of ectodermal dysplasia/skin fragility syndrome in China. Methods The clinical data, transmission electron microscopic examination and immunohistochemical analysis of this patient were evaluated. Results The patient was a 3-year-old girl who presented increased skin fragility with trauma-induced, blisters and erosions, combined with short and sparse hair, finger-and toe-nail dystrophy and palmoplantar keratoderma. Transmission electron microscopy showed a loss of keratinocyte-keratinocyte adhesion, widening of intercellular spaces and a reduced number of hypoplastic desmosomes. Immunohistochemical analysis revealed a complete absence of staining for plakophilin 1. Conclusion Ectodermal dysplasia/skin fragility syndrome is a rare autosomal recessive inherited disease characterized by clinical manifestations as well as electron microscopic features and immunohistochemical evidence.

Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy