3.A review of medical image compression techniques
International Journal of Biomedical Engineering 2008;31(2):77-81
As the increasing of digital imagilag modalities,a close-at-hand challenge to deal with is the storage and transmission requirement of enormous data of medical images.Compression is one of the indispensable techniques to solve this problem.A comprehensive review and discussions are made in this paper over the medial image compression techniques applied in medical image domain,including the latest achievements in this field.Different compression algorithm including ROI-based coding,lossless compression,DWT,neural net are introduced and some quality evaluation methods are introduced.Foreground of the field is given from our point of view.
4.The curative effect of recombinant human interferon α-2b gel on flooding prevention in loop electrosurgical excision procedure
Chinese Journal of Postgraduates of Medicine 2009;32(21):19-22
Objective To evaluate the efficacy of recombinant human interferon α-2b gel onflooding prevention in loop electrosurgical excision procedure (LEEP) during and after the operation.Method The 152 patients with cervical disease were randomly divided into three groups: group A(recombinant human interferon α-2b gel treatment group), group B (hypophysin treatment group)and groupC(control group). Results The amount of intraoperative bleeding and the amount of post-operative bleedingof the group A was (2.57±1.19) ml and (2.24±1.75) ml, the group B was (3.00±1.49) ml and (45.86±26.14) hal, the group C was (45.62±39.57) ml and (56.90±41.90) ml, respectively. There was no differencebetween group A and group B in the amount of intraoperative bleeding (P>0.05), but significantly less thangroup C (P<0.01). There was no difference between group B and group C in the amount of post-operativebleeding (P>0.05), but significantly much more than group A (P<0.01). Conclusion Recombinanthuman interferon α-2b gel is effective on reducing intraoperative and post-operative bleeding in LEEP.
5.Salient cues enhance strategy monitoring and task switching for prospective memory:An ERP study
Chinese Journal of Behavioral Medicine and Brain Science 2009;18(6):526-528
Objective To investigate the retrieval mechanism of prospective memory,spatiotemporal patterns of event-related potentials (ERP) were used to reveal neural correlates of the prospective interference effect. Methods A task of matching two sequential patterns was taken as the ongoing task and the detection of patterns with two salient levels as prospective memory tasks. Experiments were performed in blocks for single ongoing task block and two prospective memory blocks. Results No significant behavioral effect was found for prospective interference [reaction time(ms):control blocks 750.29±161.33,high salience blocks 770.94±174.89,low salience bocks 764.79±174.12,F(1.52,25.82)=0.48,P =0.57 and correction rate(%):control blocks 85.89±8.07,high salience blocks 88.26±7.00,low salience blocks 87.91±7.28,F(1.50,25.57)=2.46,P =0.12].But significant ERP effect was found at bilateral frontal regions from 160 ms to 240 ms for both two prospective memory blocks. Moreover,greater negativity at the right frontal polar region appeared significantly at 360'440 ms for higher salient patterns. Conclusion Prospective memory is retrieved based on strategic monitoring and high salient stimuli may enhance to keep the prospective goal and improve task switching.
6.Translational approach for pharmacogenomics and personalized medicine.
Acta Pharmaceutica Sinica 2011;46(1):1-5
Pharmacogenetics and pharmacogenomics are promising fields that will enable personalized therapy. However, one of the most important issues to be conquered in the practice of personalized medicine is the translation of scientific discoveries into better therapeutic outcomes. The international pharmacogenetic and pharmacogenomic approaches made in the field of personalized medicine and drug discovery are summarized in this review.
7.Determination of Baicalin and Berberine Hydrochloride in Compound Qinbo Granules by HPLC
Traditional Chinese Drug Research & Clinical Pharmacology 2009;20(4):349-351
Objective To establish a HPLC method for the determination of baicalin and berberine hydrochloride in Com-pound Qinbo Granules. Methods The gradient elution was performed on a Diamonsil C18 column using method-water (0. 05 % phosphate acid and 0. 1% trithylamine) as mobile phase, and the detection wavelength was 276 nm. Results The linear calibration curve of baicalin was obtained in the range of 10. 08~201.6 mg·L-1 with an average recovery of 98. 1% (RSD=1.11%). The linear calibration curve of berberine hydrochloride was in the range of 4. 08~81.6 mg·L-1 with an average re-covery of 97.9 % (RSD=1.24 %). Conclusion The method is simple and reproducible. It can be used for the quality con-trol of Compound Qinbo Granules.
8.The diagnosis value of magnetic resonance diffusion weighted imaging for breast cancer
Chinese Journal of Primary Medicine and Pharmacy 2012;19(14):2087-2089
Objective To explore the differential diagnosis value of DWI ADC for breast lumps,improve the diagnosis of breast cancer specificity.Methods 93 patients with 105 breast tumors were performed with routine MR series and DWI,and the ADC values were measured.Results Lesions ADC values:average ADC value 43 benign lesions in 37 cases was(1.37±0.36)×10-3 mm2/s,the different value between max and min was(0.63±0.19)×10 -3s/mm2.Average ADC value of 62 malignant lesions in 58 patients was(0.90±0.53) × 10 -3 mm2/s,the different value between max and min was(0.91±0.27)×10-3 mm2/s.By statistical analysis,both average ADC values and the max and the min ADC difference value were very significantly different(P<0.01).Draw diagnosis benign and malignant lesions ROC curves,with ADC values 0.11×10 -3 mm2/s for critical value to judge benign and malignant standard,sensitivity was 67%,specificity was 72%.With 1.0×10- 3 mm2/s for critical value,specificity can raise to 84%,and sensitivity came to 60%.With the maximum and minimum ADC difference value 0.75 × 10-3s/mm2 for critical value,sensitivity was 67%,specificity was 68%.If with 0.80 for critical value,sensitivity was 53% and specificity 82%.Conclusion The average ADC values of DWI were significant for the identification of benign and malignant lesions.
9.To build top universities:reason,practice and comparison
Chinese Journal of Medical Education Research 2011;10(1):22-28
It is a strategic choice for a country to build top universities for innovative talents and independent innovative products.Germany,South Korea,Japan and Chinese Taiwan and Mainland are taking great measures to build top universities.In comparison with Project 985 universities under the direct administration of the Ministry of Education of China and world top universities in their environment,research,teaching and disciplines,key construction strategy including integration of distinctive resources to build top university system should be kept up,core competency cultivation,proper development environment and major features should come into being,and scientific HEIs categories should be established in building top universities in China.
10.Advances in colitis-associated colorectal cancer and dysplasia
International Journal of Surgery 2011;38(5):342-345
Patients with long-standing history of ulcerative colitis have an increased risk of developing colitis-associated colorectal cancer.The risk factors include longer duration of colitis,greater anatomic extent of colitis,degree of inflammation of the bowel,family history of colorectal callcer,the presence of primary sclerosing cholangitis.etc.The two kinds of molecular pathogenesis that contribute to colon carcinogenesis are chromosomal instability and microsatellite instability.In order to reduce cancer morbidity,colonescopic surveillance and chemoprevention should be carried out in patients with ulcerative colitis especially in those high risk patients.New endoscopic techniques increase the sensitivity and shed a new light on tumor surveillance.