The strategies for constructing pharmaceutical subject repository union in China and the development trend of pharmaceutical subject repository union were studied form the aspects of its cooperation models, platform building, resources acquisition and organization, access policy formation;copyright, quality control, and fund source.The cooperation models were divided into centralized storage model, distribution acquisition model and hierarchical construction model.Pharmaceutical subject repository union platform was built according to the different cooperation models.

Objective:To evaluate the emergency diagnosis of severe myocardial contusion. Methods:Thirty patients with serious blunt chest trauma underwent sonourethrography,all of whom underwent conventional myocardial markers simultaneously.All the observation time phases were set as 1 h,2 h,4 h and 8 h after injuries. Results:Both the concentrations of cardiac troponin T (cTn-T)and cardiac troponin (IcTn-I)at 8h after injuries were significantly higher than those at 1h after injuries(P

Objective To study chronic bronchitis rats oxidant/antioxidant related indicators Ho flavored Dingchuan Decoction.Methods 50 SD rats were adopted improved smoked method to make chronic bronchitis model.From the 20th day of the modeling,blank control group and model control group gavage were treated with saline.The positive control group were treated with Cough Mixture.The experimental groupwere dealed with Ho flavored Dingchuan Decoction high,medium and low-dose.20 day later,the cotent of SOD,CAT,MDA in rat serum,lung tissue and balf were observed.Results Compare to blank control group,the cotent of SOD[(188.11 ± 9.37)U/ml、(276.11 ±30.28) U/ml,(8.80 ± 1.49)U/ml],CAT[(9.40 ±2.04)U/ml,(26.57±4.26)U/ml,(1.58±0.26) U/ml] in rat serum,lung tissue of the experimental group significantly reduced (P ＜0.01) ; MDA [(5.64 ± 0.52) μmol/L,(6.32 ± 2.10) μmol/L,(28.08 ± 2.43) μ mol/L) increased (P ＜0.05 or P ＜ 0.01).Ho flavored Dingchuan Decoction can effectively reverse these changes,and showed a significant dose-dependent.The Ho flavored Dingchuantang,in middle and high-dose serum SOD [(253.05 ± 7.81) U/ml,(256.92 ± 5.37)U/ml],CAT [(14.86 ± 2.49)U/ml,(18.22 ± 2.65)U/ml] higher than those of blank control group.And the Ho flavored Dingchuantang,in middle and high-dose lung tissue SOD [(470.91 ± 11.46)U/mgprot,(482.91 ± 14.32)U/mgprot),CAT [(46.87 ± 3.75)U/mgprot,(55.49 ±3.33)U/mgprot] higher than those of blank control group.Content close to the normal level.Conclusion The Ho flavored Dingchuan Decoction has significantly reduce the oxidative stress in chronic bronchitis.

AIM: To investigate the clinical effect of compound anisodine on patients with paralytic strabismus and the influence on malondialdehyde ( MDA ) and superoxide dismutase ( SOD) .
●METHODS: Seventy cases diagnosed with paralytic strabismus from Jun. 2008 to Dec. 2014 were selected as treatment group; another 70 cases with paralytic strabismus from Oct. 2000 to Jan. 2008 were chosen as control group. The control group was given with conventional therapy, and treatment group was additionally injected with compound anisodine subcutaneously on the basis of the control group. Treatment lasted for two courses about 28days. The effect of compound anisodine on patients with paralytic strabismus was evaluated and the serum level of MDA and SOD was also measured before and after treatment.
●RESULTS: ln treatment group, 54 cases were cured (77%), 14 cases improved (20%) and 2 cases had no response ( 3%) and total efficiency reached to 97%. ln control group, 32 cases were cured ( 46%) , 21 cases improved ( 30%) and 17 cases had no response ( 24%) and total efficiency was 76%. The cure rate and total efficiency of treatment group were significantly higher than that of control group (P<0. 05). Before treatment, the level of SOD and MDA was equal in two groups. After treatment, increased SOD level and decreased MDA level was observed in both groups. However, compound anisodine were significantly increased SOD level and reduced MDA level when compared with conventional therapy (P<0. 05).
●CONCLUSION: The compound anisodine shows the beneficial effect on patients with paralytic strabismus. Compound anisodine may exert the effect via increasing SOD and reducing MDA.

Circulating tumor cells (CTCs) play pivotal roles for monitoring the tumor metastasis and prognosis.The nanotechnology provides a favourable platform for CTCs detection,and enables CTCs to be more promising for practical application.Meanwhile,the nanoscale device by virtue of nanotechnology has broad application prospects in eliminating CTCs and offers a new direction in the field of anti-cancer.

Objective To observe serum homocysteine (Hcy) levels in retinal vein occlusion (RVO) patients with different ages and types.Methods A total of 79 patients (79 eyes) diagnosed with RVO were enrolled.There were 33 females and 46 males,the mean age was (57.00± 9.29) years.Eighty-two age-and sex-matched patients (82 eyes) without retinal vascular disease were included as controls.There were 32 females and 50 males,the mean age was (60.00± 10.15) years.Among RVO patients,there were 24 patients younger than 50 years old (young patients) and 55 patients older than 50 years old (elderly patients);35 patients with central RVO (CRVO) and 44 patients with branch RVO (BRVO).Fasting plasma Hcy,serum vitamin (Vit) B6,B12 and folate levels were measured in all patients.The relationship of high Hcy,low VitB6,low folate and RVO with different age were analyzed.Results Hcy level was significantly higher in RVO patients than control subjects (t =2.946,P ＜ 0.01).Blood concentration of folate and VitB6 were significantly lower in RVO patients than control subjects (t=2.641,2.889;P＜0.01).Blood level of VitB12 was significantly different in RVO patients from control subjects (t =1.665,P＞0.05).Concentrations of Hcy,folate,VitB12 and VitB6 were not different between patients with CRVO and BRVO (t =0.756,1.306,0.682,1.306;P＞ 0.05).Hcy level was significantly higher in the young RVO patients than in the elderly RVO patients (t=2.394,P＜0.05).Blood concentration of folate and VitB6 were lower in the young RVO patients than in the elderly RVO patients,but the difference were not significant(t=1.318,1.694;P＞0.05).The number of patients with high Hcy [x2=13.67,odds ratio (OR) =3.327,95％ confidence interval (CI) =1.742-6.354],low VitB6 (x2 =5.28,OR =2.068,95％CI=1.103-3.878) and low folate status (x2 =8.642,OR=2.546,95％CI=1.349-4.806) in RVO patients were more than control subjects (P=0.0001,0.023,0.004).Conclusions High Hcy,low folate and low VitB6 were risk factors for the onset of RVO.Hcy may play more important role in young patients with RVO.Hcy,folate and VitB6 levels were similar in CRVO and BRVO patients.

Mutiple myeloma(MM)has been associated with the hypercoagulable states and the development of venous thromboembolic events(VTE). Described pathogenetic mechanisms that are not exclusive to MM include the abnormality of blood clotting components,the dysfunction of fibrinolysis,the disorder of platelets,the abnormity of blood stream and blood viscosity,etc..It has been proved that high levels of vascular endothelial growth factor (VEGF),von Willebrand factor (vWF),increased production of inflammatory cytokines and higher expression of COX-2 in MM seem to be associated with the hypercoagulability. In addition, the treatment of MM may also result in the treatment-associated hypercoagulable states.

Chronic atrophic gastritis, which is the precancerous lesions of gastric cancer, has no good effect in west-ern medicine treatment. However, traditional Chinese medicine (TCM) has achieved certain effect in recent years. This article mainly discussed from aspects of etiology and pathogenesis, syndrome differentiation, therapies and for-mulas, acupuncture treatment, famous doctors’experiences, and integrative medicine treatment. The research pro-gress was summarized on TCM treatment and integrative medicine of this disease in recent 5 years.

ObjectiveTo observe the clinical efficacy of acupoint thread embedding plus psychotherapy for insomnia due to disharmony betweenheart and kidney during perimenopause.MethodForty-three patients with insomnia due to disharmony between heart and kidney during perimenopause were intervened by acupoint thread embedding plus psychotherapy including cognitive and behavioral therapies,and then the therapeutic results were statistically analyzed.ResultOf the 43 subjects, 19 were clinically cured, accounting for 44.2%; 13 subjects were markedly improved, accounting for 30.2%; 9 were improved, accountingfor 20.9%; 2 subjects failed, accounting for 4.7%. The total effective rate was 95.3%. The serum E2level was significantly changed after intervention (P<0.01).ConclusionAcupoint thread embedding plus psychotherapy can produce a significant efficacy in treating insomnia due to disharmony between heart and kidney during perimenopause, and this method can up-regulate the serum E2level, enhance the production of estrogen, and improve ovary function.

For the case study group,52 pregnant women diagnosed as abnormal glucose metabolism and requiring in-hospital glucose control were selected for continuous glucose monitoring.And another 49 pregnant women with known glucose levels through serial glucose monitoring at the same period were taken as case control group.We divided the case study group into A1,A2 and B based on White's typing.In case study group,the glucose levels peaked at 8 to 10 am and dropped to the lowest levels at 10 pm to 6 am on the next day.The glucose of A2 group was markedly higher than that of A1 group.The highest postprandial glucose of case study group happens at (1.6 ± 0.5) h after breakfast,(1.6 ± 1.2) h after lunch and (1.6 ± 0.8) h after dinner.The blood glucose wavy coefficient of patients of A1 and A2 groups had significant statistical difference.The newborn weight of case study group was lower than that of case control group.