Based on the dynamic performance of radial force sensor detection and TCM pulse waveform technology, the paper described a kind of testing equipment being developed which tests both radial force sensor performance and the dynamic performance of the instrument of pulse detection. The device covers requirements for static and dynamic performance test of the radial artery pulse wave force sensor and pulse diagnosis instrument, thus it makes a change to compute frequency response of the sensor by directly measurement.
Equipment Design ; Humans ; Pulse ; Radial Artery ; Transducers

Combined Modality Therapy ; Eczema ; diet therapy ; drug therapy ; Feeding Behavior ; Humans

Duchenne muscular dystrophy(DMD)is a fatal muscular wasting disease in children.Because of various factors such as DMDˊs low incidence,quick progression,limited knowledge of this disease,and treat-ment outcomes of respiratory failure,heart failure has become the leading cause of death in these patients.Early diagnosis and treatment is essential for prolonging the survival time and improving the quality of life.This review describes recent progress in the study of epidemiology,pathogenesis,early diagnosis,prevention and treatment of cardiac injury in patients with DMD.

Solanum Nigrum is a kind of dicotyledon solanaceae annual herb, and alkaloids are its main bioactive constituents, with good antitumor activity. The current extraction methods for alkaloids include solvent extraction, ultrasonic extraction, microwave extraction, supercritical fluid extraction, and column chromatography etc, while the detection methods include acid dye colorimetry, thin layer scanning, high performance liquid chromatography, reversed-phase high performance liquid chromatography, and ultra-high performance liquid chromatography etc. This article reviewed the research progress in extraction and detection methods of alkaloid from Solanum Nigrum in recent years, so as to provide references for further research and development of alkaloid from Solanum Nigrum.

Objective To explore the clinical effect of different scheme of moxifloxacin and levofloxacin for elderly multi drug resistant pulmonary tuberculosis.Methods 136 cases of elderly patients included in the study were randomly divided into the observation group 1 and observation group 2 with 68 cases in each group according to the sequence in group.The observation group 1 used moxifloxacin regimen for treatment of pulmonary tuberculosis while the observation group 2 used levofloxacin regimen.The two groups were treated for 18 months and observed the clinical curative effect,and the sputum negative,pulmonary lesions absorption,empty changes and adverse reactions.Results The total efficiency of the observation group 1 was 92.6％,which in the observation group 2 was 72.1％,the total efficiency of the two groups had a significant difference (x2 =9.917,P =0.002) ;the sputum negative conversion rate of the observation group 1 at the end of 3 months was significantly higher than that of the observation group 2 (x2 =4.115,P =0.043),no significant difference was found at the other time points (all P ＞ 0.05) ; after treatment,the obvious absorption + absorption of lung lesion in the observation group 1 was 59 cases,accounting for 86.8％,that in observation group 2 was 48 cases,accounting for 70.6％,two groups of lung lesions absorption had significant difference (x2 =5.303,P =0.021) ; the pulmonary cavity closure + reduced in the observation group 1 was 52 cases,accounting for 76.4％,that in the observation group 2 was 41 cases,accounting for 60.3％,with significant difference between the two groups (x2 =4.115,P =0.043) ;there was no significant difference in adverse reaction of the two groups (P ＞ 0.05).Conclusion Moxifloxacin anti tuberculosis regimen has a better curative effect in treatment of elderly patients with multi drug resistant pulmonary tuberculosis,which should be expanded the application.

Purpose To investigate the MRI findings and to improve the understanding of spinal epidural angiolipomas. Materials and Methods MRI findings were retrospectively analyzed in two cases of surgery and pathology proven spinal epidural angiolipomas. Relevant literatures were reviewed. Results Two cases of spinal epidural angiolipomas were located in the lumber and lower thoracic spinal canal. The tumors were elongated or spindle in shape within the epidural space, and parallel to the longitudinal axis. In both cases part of the tumors were hyperintense on T1WI and T2WI, attenuated on fat-saturated sequences with mild enhancement. Some areas were hypointenseon T1WI, hyperintenseon T2WI, unattenuated on fat-saturated sequences with apparent enhancement. Angiolipomas were classified according to the MRI features. One was type I and the other was type III. Both cases were non-infiltrative. Conclusion MRI shows the size, shape, MRI signals and the association with the adjacent structure of spinal epidural angiolipomas. The MRI classification is helpful for improving the understanding of the tumor. MRI is the best imaging modality to diagnose spinal epidural angiolipomas.

Objective To observe the effect of different periodontal therapies on serum levels of tumor necrosis factor-alpha (TNF-α),interleukin-6(IL-6)and C-reactive protein (CRP)in elderly patients with coronary.Methods Totally 90 elderly patients with severe periodontitis were divided into three groups,the control group performed the treatment of coronary heart disease;the periodontal treatment group performed the treatment of coronary heart disease and periodontal treatment;the combine group per-formed periodontal therapy and flap surgery on the basis of the treatment of coronary heart disease.The obvervational index were compared among three groups.Results All patients′clinical indexes of periodontitis of combination group and basic group has im-proved after treatment,the levels of PD,SBI,CAL,PLI,the percentage of bleeding on probing and probing depth were significantly decreased (P <0.05),and had significant adhesion(P <0.05);the contrast between combination group and basic group,the levels of PD,SBI,CAL,the percentage of bleeding on probing and probing depth had notable difference(P <0.05).All patients′clinical indexes of periodontitis of combination group and basic group had improved after treatment,serum levels of TNF-α,IL-6 and CRP were significantly decreased (P <0.05);the contrast between combination group and basic group,serum levels of TNF-α,IL-6 and CRP have notable difference (P <0.05).Conclusion The periodontal basic therapy and periodontal flap therapy can reduce the ser-um levels of TNF-α,IL-6 and CRP of elderly coronary heart disease (CHD),but compared to the routine medicine maintenance therapy,the effect of periodontal flap therapy is better.

Objective To investigate the roles of interleuldn (IL)-17,IL-10,and matrix metalloproteinase12 (MMP-12) in the pathogenesis of atherosclerosis and further to understand the intervention mechanism of atorvastatin for atherosclerosis.Methods Eighteen Japanese white rabbits were randomly divided into 3 groups:control,model and intervention groups (n =6 in each group).The control group,model group and intervention group were fed basic diet,high-fat diet,and high-fat diet plus atorvastatin (5 mg/(kg·d),respectively for 12 weeks.The levels of serum total cholesterol (TC) and triglyceride (TG) were determined by enzymatic colorimetric method; the levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined by selective precipitation method; the levels of IL-17,IL-10,and MMP-12 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA); the pathological morphology changes of atherosclerotic plaque was observe by HE staining; and the thickness of the intima,intima/media ratio,plaque area,and plaque proportion were calculated by image analysis software.Results The expression levels of serum TC,TG,LDL-C,and IL-17,as well as those of IL-17 and MMP-12 of the intervention group were significantly lower than those of the model group (all P ＜0.05),but they were still higher than the control group (all P ＜0.05),while there was no significant difference in the level of HDL-C.The level of serum IL-10 of the intervention group was higher than that of the model group and the control group (all P＜0.05).The thickness of intima,intima/media ratio,plaque area,and plaque proportion of the intervention group were all significantly lower than those of the model group (all P ＜0.05).Correlation analysis showed that the plaque proportion was significantly positively correlated with IL-17 (r =0.847,P =0.001) and MMP-12 (r =0.839,P =0.001),and was negatively correlated with IL-10 (r =0.794,P =0.002); IL-17 was significantly positively correlated with MMP-12 (r =0.709,P=0.001),and was significantly negatively correlated with IL-10 (r =0.738,P＜0.001).MMP-12 was significantly negatively correlated with IL-10 (r =0.563,P =0.015).Conclusion The increased levels of IL-17 and MMP-12,as well as the decreased level of IL-10 illustrate that inflammatory factors play an important pathological role in the pathogenesis of atherosclerosis.In addition to lipid-lowering effect,atorvastatin may decrease the degree of chronic arterial inflammatory response and play a role in anti-atherosclerosis by decreasing the expression of IL-17 and MMP-12,as well as increasing the expression of IL-10.

Human sex glands (ovary and testis) play extremely important roles in reproductive function and sexual behavior by secreting various hormones.However,complex changes in the structure and the function of sex gland occur with ageing,resulting in a series of clinical consequences.This article explores these changes and discuss about their diagnosis and treatment.

Objective: To observe the clinical effect of mild moxibustion for facial paralysis.Methods: One hundred cases of facial paralysis were divided randomly into two groups: 50 cases in the treatment group were treated by mild moxibustion, and 50 cases in the control group were treated by oral administration of Cobamamide Tablets. With ten days as one course of the treatments, two courses of the treatments were given. The therapeutic effects were assessed four weeks after treatments. Results: The total effective rate was 96.0% in the treatment group and 88.0% in the control group, and there was statistical difference in the therapeutic effects between the two groups (P<0.05). Conclusion: The therapeutic effect of mild moxibustion for facial paralysis is better than oral administration of Cobamamide Tablets.