Objective To observe the effects of Tongbi Shuxin Granule on life quality of acute coronary syndrome (ACS) patients with anxiety and depression.Methods Ninety patients were randomly divided into the treatment group and control group through random number table method, 45 cases for each group. The control group was given fundamental treatment and emotional intervention, while the treatment group was given Tongbi Shuxin Granule additionally. On admission and 4th and 12th weeks, the scores of HAMA and HAMD were evaluated. On admission and 12th week, SAQ score was observed.Results In the 4th week, scores of HAMD and HAMA of two groups decreased compared with those on admission (P<0.05), with statistical significance (P<0.05). In the 12th week, scores of HAMD and HAMA of the control group were lower than those of 4th week, without statistical significance (P>0.05);the treatment group decreased significantly compared with on admission and 4th week (P<0.05), without statistical significance between the two groups (P<0.05). In the 12th week, all dimensions of SAQ score in the two groups increased compared with those on admission (P<0.05);the treatment group was much higher than the control group, especially the scores of physical limitation, angina stability and angina frequency (P<0.05).Conclusion Tongbi Shuxin Granule has the exact treatment effects on ACS patients with anxiety and depression.