Objective To compare the clinical effects of laparoscopy and traditional open surgery in the treatment of left colon cancer.Methods 58 patients with left colon cancer were randomly divided into the control group (27 cases) and the treatment group (31 cases).The control group was treated by traditional open surgery,the treatment group was treated by laparoscopic surgery.The operative time,blood loss,postoperative analgesia,postoperative exhaust time,length of hospital stay and number of lymph node dissection of the two groups were observed and compared.The postoperative complications were observed.Results The blood loss,postoperative analgesia,postoperative exhaust time,length of hospital stay of treatment group were less than those of the control group (t =0.648,0.619,0.588,0.497,all P ＜ 0.05) ; while the operative time,the number of lymph nodes dissection of the two groups showed no significant differences (t =0.135,0.209,all P ＞ 0.05).The incidence rate of postoperative complications of the control group was 18.5％,which was significantly higher than 9.7％ of the treatment group (x2 =17.03,P ＜ 0.05).Conclusion Laparoscopic surgery in the treatment of left colon cancer has less blood loss,shorter hospital stay,fewer complications,it has high clinical application value.

Objective:To investigate the clinical application of PPH plus external hemorrhoidectomy in the treatment of hem- orrhoids. Methods:Sixty-eight cases of Ⅲ-Ⅳdegree Ring-like mixed hemorrhoids treated by PPH from January 2004 to Jan- uary 2007 were respectively reviewed. Results:A post operation follow-up found no anus incontinence, stenosis of stoma and recurrence. Conclusion:PPH plus external hemorrhoidectomy can widen the indications for PPH and improve patients’satis- faction.

Objective:To compare with curative effect,hospital stay,average cost,recovery time and postoperative complication between local anesthesia and epidural anesthesia stratege for tension-free hernioplasty in middle or old-aged patients.Methods:164 cases were randomly divided into local anesthesia and epidural anesthesia groups.Results:Mean operating time,the time of hospital stay and the rate of postoperative complication in local anesthesia groups were less than that in epidural anesthesia groups.Conclusion:Tension-free hernioplasty under local anesthesia,a more safe,effective and cheap operating method in middle or old aged patients with inguinal hernia,should be widespread.

ObjectiveTo observe the effect of probucol combined with atorvastatin in treatment of stenosis carotid atherosclerosis.MethodsEighty-six patients with stenosis carotid atherosclerosis were separated into two groups with 43 cases each by random digits table.The patients were treated with probucol combined with atorvastatin in observation group and atorvastatin only in control group.The changes of arteriosclerotic plaque and blood fat pre- and poet-treatment were observed.Results There was no significant difference in the levels of lumen area (LN) and intima-media thickness (IMT) pre-treatment between two groups (P＞ 0.05).Compared with pre-treatment,the levels of LN and IMT post-treatment were significantly decreased in observation group(P ＜ 0.05 ),while no significant difference in control group (P ＞0.05).There was significant difference in the levels of LN and IMT post-treatment between two groups [(0.59 ±0.19) cm2 vs.(0.72 ±0.28) cm2,(2.76 ±0.41 ) mm vs.(3.27 ±0.57) mm](P＜ 0.05).There was no significant difference in the levels of total cholesterol (TC),triacylglycerol (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) pre-treatment between two groups (P ＞0.05).Compared with pre-treatment,the levels of TC,TG,LDL-C post-treatment were decreased,HDL-C was increased,there were significant differences (P ＜ 0.05 ).Post-treatment,the levels of TC,TG,LDL-C in observation group were lower and HDL-C was higher than those in control group (P ＜ 0.05).Conclusion Probucol combined with atorvastatin in treatment of stenosis carotid atherosclerosis can improve arteriosclerotic plaque and low blood fat,which can be applied in clinic.

Objective To observe the effectiveness of probucol for non-proliferative diabetic retinopathy (NPDR) with hyperlipidemia.Methods Fifty-two patients (104 eyes) of NPDR with hyperlipidemia were enrolled in this study.The patients were randomly divided into treatment group and control group,26 patients (52 eyes) in each group.Both groups received diet and exercise guidance,oral hypoglycemic agents and (or) intensive insulin therapy.After blood sugar and blood pressure were controlled,the treatment group received probucol 0.5 g,two times per day; and the control group received atorvastatin of 10 mg,one time per day.The total course was 12 months.Before and after one,three,six and 12 months,all patients underwent vision,ophthalmoscope,fundus fluorescein angiography,blood and urine tested.Variations of visual acuity,fundus condition,macular edema,triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDLC),high-density lipoprotein cholesterol (HDLC) and 8-0HdG were observed before and after treatment.Results The total effective rate of visual prognosis were 44.23％ and 40.38％ in the treatment group and the control group,the difference had no statistical significacy (Z＝-0.335,P＞0.05).Retinal hemorrhages and microaneurysms alleviated after treatment in both groups.The total efficiency of fundus prognosis was 65.38％ in the treatment group and 36.54％ in the control group,and the difference was statistically significant (Z=-2.973,P＜0.05).Macular edema was in six and five eyes in the treatment group and the control group respectively,which were lower than before treatment,the difference was statisticaly significant (x2=4.833,4.300; P＜0.05).Between the two groups,the difference was not statistically significant (x2 =0.102,P＞ 0.05).Twelve months after treatment,TG,TC and LDLC were decreased in the treatment group (t=15.653,7.634,14.871) and control group (t=13.275,7.415,13.632),and the difference was statistically significant (P＜0.05).HDLC showed no significant difference than before in the two groups (t=0.584,0.275; P＞0.05).TG,TC,LDLC and HDLC showed no difference between the two groups (t＝1.857,0.133,1.671,0.875; P＞0.05).8-0HdG decreased gradually during the one,three,six and 12 months in the treatment group (t=7.352,15.581,27.324,28.143) and control group (t =6.877,8.672,14.671,14.855) after treatment,and the difference was statistically significant (P＜0.05).In the first month aftertreatment,8 0HdG showed no difference between the two groups (t=0.513,P＞0.05).In the 3,6,and 12 months after treatment,the 8 0HdG was lower in the treatment group than that in the control group,and the difference was statistically significant (t =3.434,5.917,5.226; P＜0.05).Conclusion In the treatment of NPDR with hyperlipidemia,probucol can reduce blood lipid,stable visual function and relieve macular edema.

Objective To investigate the correlation between plasma fibronectin (Fn) level and the hemorrhagic transformation (HT) in patients with acute ischemic stroke.Methods Patients with acute ischemic stroke,symptom onset within 72 hours,no bleeding at baseline MRI (including gradient echo sequences) and without thrombolytic therapy were recruited prospectively.At 7 - 10 days after symptom onset reexamined MRI.The patients were divided into HT and non-HT groups according to whether they had a hemorrhage or not.The plasma Fn levels in both groups were compared.Logistic regression analysis was used to investigate the predictors of HT.Results A total of 78 patients were included,and among them 11 patients (14.10％ ) showed HT.The proportions of atrial fibrillation (36.4％ vs.9.0％,P =0.012) and cardioembolism (36.4％ vs.6.0％,P =0.021) in the HT group were significantly higher than those in the non-HT group.The baseline mean systolic blood pressure (182.09 ±20.73 mm Hg [ 1 mm Hg=0.133 kPa]vs.161.25 ±26.40)mm Hg,P =0.015),mean diastolic blood pressure (98.00 ± 11.26 mm Hg vs.86.60 ± 15.21 rnm Hg,P =0.020),and plasma Fn level (4 835.04 ± 756.30 μg/L vs.3 849.44 ± 1 289.18 μg/L,P =0.016) were all significantly higher than those in the non-HT group.Multivariate logistic regression analysis showed that plasma Fn level (odds ratio [ OR],1.001,95％ confidence interval [ CI] 1.000 - 1.001,P =0.017) and atrial fibrillation (OR,13.408,95％ CI 1.963 -91.592,P =0.008) were the independent predictors of HT in patients with acute ischemic stroke.Conclusions The plasma Fn level in patients with HT increased significantly.The plasma Fn level can be used as an independent predictor of non-thrombolytic HT after the onset of acute ischemic stroke.

OBJECTIVE:To provide references for Chinese pharmaceutical enterprises in establishing developmental strategy for generic drug market.METHODS:This study was bases on the theory of marketing together with literature re?trieval and demonstration analysis.RESULTS&CONCLUSION:This paper has summarized the chief problems lies in the Chinese generic drug market and put forward some feasible strategies for the pharmaceutical enterprises such as to choose va?rieties of specific features based on the characteristics of enterprises;to achieve innovation in the marketing and to focus on the country market so as to enlarge the market share;to establish strategic alliances so as to strive to be the leader of generic drugs through collaboration and competition;to occupy the top market by establishing brands for generic drugs.

Diabetic retinopathy (DR) is one of the signs of complications related to diabetes in eye In clinic,there has not perfect measurement and method to prevent and treat DR.Proteomics as an emerging subject focuses on studying the organizational structure and related functions as a whole level.The application of proteomics research method can fully reveal the protein expression in tissues and cells with comparison of the difference between the normal and diabetes.The differentially expressed proteins can reveal the various factors in the pathological process of DR to address the accurate regulatory mechanism,and can find some new regulatory proteins associated with DR.This approach provides further theory and methodology to study DR,which has its unique advantages in drug-targeted treatment of DRs.

ObjectiveTo explore the clinical effects of laparoscopic common bile duct exploration and primary suture combined with choledochoscopy (LBEPS) and laparoscopic common bile and duct exploration T-tube drainage(LCHTD) on cholelithiasis.Methods101 cholelithiasis patients were selected and,grouped by the operation methods.56 cases were treated with LCHTD,while 45 cases were treated with LBEPS.The operation time,blood lose,and postoperative digest function recovery time were ampared betreen two groups.ResultsThe operation time betreen the two groups has no significant difference(P ＞ 0.05 ),while the blood lose,postoperative digest function recovery time in LBEPS group were better than the LCHTD group( all P ＜ 0.05 ),the differences were statistically significant.Meanwhile the LBEPS group had a less complication and re-treatment rate than those of the LCHTD group ( P＜0.05).ConclusionCompared with LCHTD,LBEPS had smaller trauma,less operation complications and faster postoperative digest recovery time,worthy of clinical promotion.

Effective strategies to sterilize and disinfect the surface of sickbed should be adopted before the sickbed is moved into or out of an operation room.Ozone produced by Nano technology is used as disinfector.The experiments shows that the killing logarithm value to kill nature bacteria is between 0.54 and0.85 in short time.The effect of sterilization and disinfection for the surface of sickbed is satisfying without secondary pollution,so the new method can be used to sterilize and disinfect sickbed.