1.On the Legal Capacity of Fetal Rights——An Analysis from the Ethical and Legal Perspective
Chinese Medical Ethics 1995;0(02):-
There are many arguments on the legal capacity of fetal rights for a long time,but no definite conclusion has ever been reached.Based on ethics and approached in jurisprudence,this article tries to jump out of the traditional mode to analyze the reasons for the independent personality of fetus and justify the view that legal capacity of fetal rights does not necessarily require additional restrictions.The legal capacity of fetal rights origins from social ethical values.Morality distinguishes right from wrong,law pursuits for justice,and moral value is the basis of the law and human nature.The definition of legal "person" should first respect for the objectivity of human development process and the nature of human.It's necessary to recognize the independent personality of fetus,protect the vulnerable groups,and the people in the most vulnerable stage of human development on the basis of social moral value.The directive function of law on morality should be enhanced in our nomocracy-favored society,so as to achieve the reunification of fetal rights in the context of harmonious society construction and realize the human virtue of excellence and harmony.
2.Comparison of dissolution of asperosaponin Ⅵ between ultra-micro powder and fine powder of Radix Dipsaci
Chunfeng ZHANG ; Kai LI ; Zhonglin YANG
Chinese Traditional Patent Medicine 1992;0(01):-
AIM:To compare the dissolution of asperosaponin Ⅵ between the ultra-micro powder and the fine powder of Radix Dipsaci.METHODS:The real contents,in vitro release and releasing rate of asperosaponin Ⅵwere determined by HPLC for the ultra-micro powder and the fine powder.RESULTS:In the ultra-micro powder and the ordinary powder,the real content of asperosaponin Ⅵ were 4.87%,4.74%,respectively;in vitro release in 1 h were 48.2 mg/g,47.5 mg/g,respectively;releasing rate parameter T_ 0.9 were 0.23 min,10.41 min,respectively.CONCLUSION:The ultra-micro porphyrization could not influent the real content and in vitro release of asperosaponin Ⅵ in Radix Dipsaci.But it could improve the releasing rate of asperosaponin Ⅵ.
3.Comparison of dissolution of asperosaponin Ⅵ between ultra- micro powder and fine powder of Radix Dipsaci
Chunfeng ZHANG ; Kai LI ; Zhonglin YANG
Chinese Traditional Patent Medicine 2010;(1):100-102
AIM: To compare the dissolution of asperosaponin Ⅵ between the ultra-micro powder and the fine powder of Radix Dipsaci.METHODS : The real contents,in vitro release and releasing rate of asperosaponin Ⅵ were determined by HPLC for the ultra-micro powder and the fine powder.RESULTS: In the ultra- micro powder and the ordinary powder,the real content of asperosaponin Ⅵ were 4.87%,4.74%,respectively; in vitro release in 1 h were 48.2 mg/g,47.5 mg/g,respectively; releasing rate parameter T_(0.9) were 0.23 min,10.41 min,respectively.CONCLUSION: The ultra- micro porphyrization could not influent the real content and in vitro release of asperosaponin Ⅵ in Radix Dipsaci.But it could improve the releasing rate of asperosaponin Ⅵ.
4.Cerebral small vessel disease and post-stroke depression
Zhonglin LI ; Guinan BI ; Shengliang SHI
International Journal of Cerebrovascular Diseases 2017;25(4):371-374
The post-stroke depression (PSD) is one of the common complications of stroke.It can not only delay the recovery of the neurological function in patients, seriously affect the quality of life of patients, but also increase the mortality and morbidity.More and more attention has been paid to the pathogenesis of PSD.Recent studies have confirmed that brain small vessel disease is closely related to the occurrence of PSD.This article reviews relationship between brain small vessel diseases and PSD.
5.The comparison of endoscopic and histological findings between antrum and corpus in functional dyspeptic patients
Peng LI ; Shutian ZHANG ; Zhonglin YU
Chinese Journal of Practical Internal Medicine 2001;0(10):-
Objective To compare the differences between antrum and corpus in endoscopic and histological diagnosis in non-ulcer dyspeptic patients.Methods 132 cases from out-patient department who had been ordered to undergo gastroendoscopy for dyspepsia were enrolled in the study.After endoscopy,different signs including redness,erosion,intramural bleeding and rugal atrophy were described.Histological diagnosis was defined according to the classification of chronic inflammation,polymorphonuclear neutrophil activity,glandular atrophy,intestinal metaplasia,helicobacter pylori and dysplasia.The differences between antrum and corpus in endoscopic and histological diagnosis were analyzed.Results Redness and erosion under endoscopy,glandular atrophy and chronic inflammation in histological diagnosis were found more frequently in antrum than in corpus.P values were less than 0.001,0.01,0.001 and equaled to 0.025 respectively.Conclusion In functional dyspeptic patients,there are differences in the endoscopic and histological findings between antrum and corpus.Redness and erosion in endoscopic diagnosis,glandular atrophy and chronic inflammation in histological diagnosis are more common in antrum when compared with that in corpus.
6.The Expression and Significance of TSP-1 in Breast Cancer
Hongchao WANG ; Haiping LI ; Zhonglin FAN ; Yuntao LI
Tianjin Medical Journal 2009;37(10):826-828
Objective: To investigate the correlation of thrombospondin-1(TSP-1) expression and angiogenesis and clinical pathologic factors in breast cancer. Methods:Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of TSP-1 mRNA in the primary breast cancer tissues and the tissues set apart 5 cm from the tumor. Im-munohistochemistry was used to detect the expressions of vascular endothelial growth factor (VEGF), c-erbB2, estrogen receptor (ER), progesterone receptor (PR) and microvessel density (MVD). All data were statistically analyzed. Results: The positive rate of TSP-1 was significantly higher in breast cancer than that in tissues set apart 5 cm from tumor (P < 0.05). The expression of TSP-1 was positively correlated with tumor size only (P < 0.05). MVD was lower in TSP-1 positive group than that of negative group (P< 0.05). Conclusion: The MVD was decreased with up-regulation of TSP-1 expression. Thrombospondin-1 may repress the angiogenesis in breast cancer.
7.The contain of IL-1β in rat brain after subarachnoid hemorrhage and its relation to secondary brain edema
Li FENG ; Zhonglin LI ; Peizhi JI ; Bingchao YAN
Chinese Journal of Primary Medicine and Pharmacy 2013;20(2):197-199
Objective To investigate the changes of interleukin-1β (IL-1β) in rat brain after subarachnoid hemorhage (SAH) and its relation to cerebral edema and vasospasm.Methods Subarachnoid hemorrhage rat model was produced by anterior cerebral artery perforation method.The brain water content was measured by dry-wet weight method.Hematoxylin-eosin (HE) staining was used to assess vasospasm in the basilar artery,and the expression of IL-1β after SAH was examined by Western blot.Results After SAH,the cerebral edema gradually occured from 1 d,reached the peak at 7d.The level of IL-1β protein started to increase in 1 d,reached its peak in 7d,and remained at a relative high level in 14d.There's correlation between the level of IL-1β protein and changes of cerebral edema.Conclusion After SAH,The level of IL-1β gradually rised and fits remarkably well with the time course of cerebral edema,which may indicate that IL-1β leads to the development of cerebral edema after SAH.
8.Safety and efficacy of endoscopic retrograde cholangiopancreatography for children with pancreaticobiliary diseases
Shulei ZHAO ; Peng LI ; Ming JI ; Zhonglin YU ; Shutian ZHANG
Chinese Journal of Digestive Endoscopy 2011;28(3):131-133
Objective To assess the safety and efficacy of endoscopic retrograde cholangiopancreatography (ERCP) for pancreaticobiliary diseases in children. Methods Data of 9 patients younger than 14 years who underwent ERCP at between November 2004 and May 2010 were indentified through a computer database search. Therapeutic methods, success rate and procedure-related complications were evaluated.Results A total of 9 patients underwent 17 ERCP procedures under anesthesia, including 16 therapeutic and 1 diagnostic procedure. The success rate was 94. 1% (16/17) and the complication rate was 11.8%(2/17), including 1 mild pancreatitis and 1 peri-pancreatic infection. Conclusion ERCP is an important tool with high safety and efficacy for diagnosis and treatment of pancreaticobiliary diseases in children.
9.Decreased expression of Foxp3 in patients with allergic rhinitis
Zhonglin MOU ; Zhibin ZHAO ; Huabin LI ; Yenong TAN ; Lei CHENG
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(06):-
OBJECTIVE To evaluate the role of forkhead transcription factor p3(Foxp3) in the pathogenesis of allergic rhinitis(AR).METHODS Nasal tissues and peripheral blood mononuclear cells(PBMCs) were obtained from 17 patients with AR and 11 controls.Foxp3 was detected in nasal tissues by immunohistochemisry and real-time reverse transcription polymerase chain reaction(RT-PCR).Foxp3 and CD4+CD25+T cells were evaluated in PBMCs by using ? ow cytometry.RESULTS The numbers of Foxp3+ cells was(44.2?20.5)cells/mm2 and(129.5? 35.6)cells/mm2 in nasal mucosa of two groups(P
10.Effect of laser-assisted hatching on birth weight in blastocyst cultureof low-grade cleavage embryos
LI Shishi ; ZHU Zhonglin ; SHU Chongyi ; XU Weihai
Journal of Preventive Medicine 2024;36(2):169-172
Objective:
To examine the impact of laser-assisted hatching (LAH) technique on perinatal outcomes in blastocyst culture of low-grade cleavage embryos, so as to provide insights into improving the utilization of low-grade cleavage embryos and embryo quality.
Methods:
A total of 369 single live births after transfer of thawed blastocysts following in vitro fertilization or intracytoplasmic sperm injection at Zhejiang Provincial People's Hospital were selected as subjects, and they were divided into 51 conventional culture blastocysts and 318 LAH blastocysts based on whether LAH was performed on day 4 of blastocyst culture. Gestational age, birth weight, birth defects and maternal perinatal information were collected, and the prevalence of premature birth, birth weight and birth defects were analyzed after propensity score matching (PSM).
Results:
After PSM, 98 matched cases were included in the study. There were no statistically significant differences in maternal age, body mass index, type of infertility and blastocyst age (P>0.05), indicating effective matching. The birth weight of offspring in the LAH group was lower than that in the conventional culture group [(3 261.08±432.24) g vs. (3 464.18±444.46) g; P<0.05].
Conclusion
The birth weight of offspring can be reduced by using LAH during blastocyst culture of low-grade cleavage embryos.