Tocotrienol has showed inhibition effect on a variety of cancer cells. It has different mecha-nisms in different types of cancer cells. Its anticancer effects may be mediated by anti-proliferation,anti-oxida-tion,pro-apoptotic and affecting apoptosis signal pathway. Further study on tocotrienol will provide scientific the-ory for new antitumor drugs and cancer primary prevention.

Objective To observe the clinical efficacy of acupuncture plus ozone injection in treating neuralgia due to acute herpes zoster.Method Sixty patients with neuralgia due to acute herpes zoster were randomized into a treatment group and a control group, 30 cases in each group. The control group was intervened by intravenous injection of Acyclovir, muscular injection of Mecobalamin, and external application of Acyclovir cream. The treatment group was intervened by acupuncture plus zone injection in addition to the treatment given to the control group. The time taken for the blisters to cease, crust, and decrust was observed, as well as the change of Visual Analogue Scale (VAS), and the clinical efficacies were compared between the two groups. Result There were significant inter-group differences in comparing the time for the blisters to cease, crust and decrust (P<0.01, P<0.05). The VAS scores were significantly changed after treatment in both groups (P<0.01). After treatment, the VAS score in the treatment group was significantly different from that in the control group (P<0.01). The total effective rate was 96.7% in the treatment group versus 83.3% in the control group, and the difference was statistically significant (P<0.05).Conclusion Acupuncture plus zone injection is an effective method in treating neuralgia due to acute herpes zoster.

Objective:To examine the relationship of parental rearing,self-concept and personality traits of spring bud classes.Methods:A sample of 113 students,including spring buds' 30,non-spring buds' 30,and middle schools' 43,was tested by NEO-PI-R,CAPI,EMBU and Self-concept scale.Results:①Punishment of father,rejection and denial of mother and parental partiality of control group was higher than those of spring bud classes.②Family self-concept of spring bud classes was higher than that of non-spring bud classes.③Neuroticism of control group was higher than that of spring bud classes,but extraversion,human relationship orientation and flexibility of spring bud classes were higher than those of control group.④Partiality of father had positive correlation to extraversion and face of spring bud class students.Personality,moral and family self-concept had positive correlation to harmonious of spring bud class students.Conclusion:Personality and family self-concept of spring bud class students is greatly affected by parental rearing.

ObjectiveTo investigate the effect of hyperglycemia on calcium load and cyclic AMP content in normal and STZdiabetic rat skeletal muscle.MethodsCalcium load and cyclic AMP content were measured in vivo and in vitro after incubation with 5.6mmol/L and 16.7mmol/L glucose concentration.Atom spectrum absorption assay for calcium and radioimmunoassay for cAMP were employed.ResultsHigh concentration glucose elevated cyclic AMP content and lessened calcium load significantly.Cyclic AMP also elevated in diabetic skeletal muscle incubated with even 5.6mmol/L glucose.Diabetes was necessary for high concentration glucose to elevate cyclic AMP in vitro,because cyclic AMP did not change in normal rat muscle even incubated with 16.7mmol/L glucose.But diabetes discounted the reduction of calcium load induced by 16.7mmol/L glucose.ConclusionThe effects of hyperglycemia on calcium load and cyclic AMP content in skeletal muscle may accord with its antiinsulin action,which may be involved in the mechanism of glucose toxicity.

Buprenorphine,one kind of new drugs,is abused in recent years.In this review,some determination and extraction methods for buprenorphine are introduced.The relative merits of liquid-liquid extraction,solid phase extraction,hydrolysis and derivatization methods are compared.The analytical methods such as TLC,GC,GC/MS and LC,LC/MS are discussed.

AIM: To observe the effect of glucosidorum tr ipterygii tororum (GTT) on cytokine productions in acute graft-versus-host disea se (aGVHD) mice. METHODS : C 57 BL/6 mice were exposed to radiation delivered by a linear accelerator . To es tablish a aGVHD model, the cell suspensions, which were obtained from bone marro w and spleen of the BALB/C mice, were transplanted to the radiated C 57 BL/6 mice. The recipients were treated with GTT, GTT+CsA and CsA+MTX. The serum conc entrations of IL-2, TNF-?, IL-4 and IL-10 were determined by ELISA. RES ULTS: The survival rate on day 11 in GTT group (9/10) was higher than in allogeneic bone marrow transplatation (allo-BMT) group (8/19). The concentratio ns of IL-2 and TNF-? in GTT group were significantly lower, but the concentrati on of IL-10 was remarkably higher than that in allo-BMT group ( P 0 0 5). CONCLUSION: GTT inhibited aGVHD development by regulating th e production of cytokines in the host.

Objective: To examine the relationship between parental rearing and adolescent personality traits. Methods: A sample of 637 adolescents was tested by CAPI and EMBU. Results: Neuroticism of girls is higher than that of boys, but interpersonal harmony, face and defensiveness of boys is higher than those of girls. Extraversion, openness and agreeableness of only child is higher than those of other adolescents. Most correlations between parental rearing and Adolescent personality traits are significant. Parental warmth and understanding have positive effect on adolescent extraversion, agreeableness and conscientiousness, and father punishment and mother refusal have negative effect on adolescent agreeableness and interpersonal relationship. Conclusion: Adolescent personality is greatly affected by parental rearing.

Objective To investigate the association adiponectin gene polymorphism with primary macroangiopathy in diabetes mellitus. Methods Type 2 diabetes mellitus (T2DM) patients were included, 56 patients complicated with atherosclerosis (AS) and 120 non-AS group. We evaluated their Gly15Gly polymorphism of adiponectin gene by PCR restriction fragment length polymorphism (PCR-RFLP). Results The AS patients were more likely to have GG genotype than the non-AS patients (25.0% vs 6.2%, P

Objective To investigate the polymorphism of peroxisome proliferator-activated receptors-?2(PPAR-?2) and its association with obesity in Chinese population.Methods According to BMI,89 subjects who are in normal body weight range and 116 overweighted and obese subjects were included in this study.Their Pro12Ala mutation in the PPAR-?2 gene was detected by PCR restriction fragment length polymorphism.Results Allele frequency of Ala mutation of PPAR-?2 in overweighted and obese subjects(qA=11.64%) was significantly higher than that of normal body weight group(qA=5.06%,P

Objective To explore the significance and the ultrastructural changes of platelets in patients with acute cerebral infarction.Methods Changes of platelets in 20 patients with acute cerebral infarction were observed by transmission electron microscope.Results The ultrastructural changes of platelets within 24 hours after the onset were significant,including more pseudopodium,aggregation and fusion;there were remarkable fewer alpha granules and mitochondria,the remain of mitochondria swelled and more disruption of platelet membrance were found.The degree of platelet changes consisted with the severity and sizes of cerebral infarction.The ultrastructural change of platelets was obviously restored after 2 weeks,but no restoration was found in 3 patients with large area infarction.Conclusion Ultrastructural changes of platelets in acute period of cerebral infarction were remarkable,especially a lack of alpha granules,this might be regarded as an objective index in the judgment of severity and prognosis of cerebral infarction.