1.Effectiveness evaluation for military equipment
Zhiyi ZHANG ; Jianxia ZHANG ; Jianzhong SUN
Chinese Medical Equipment Journal 1993;0(05):-
This paper introduces the effectiveness's concept and classification of military equipment. The generation, development and content of effectiveness study are also presented. The typic methods of evaluating equipment's effectiveness are emphasized. The characteristics of effectiveness evaluations for several kinds of equipments are analyzed based on examples.
2.Patent Information Analysis on Traditional Medicines Health Care
Yunyun MA ; Zhiyi SUN ; Haibo LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(5):983-988
With the increase of Chinese people's material life level, their health consciousness has become more and more intense. Chinese Materia Medica, a treasure of Chinese medicine, has made a great contribution in maintaining people's health in the history. Patent is a kind of high-value scientific literature. In this paper, we retrieved the patents of the traditional medicines used in health care worldwide. The patents were further screened by a series of processes. Finally, multi-angle analysis was carried out on the dataset to form a patent analysis report of traditional medicines in health care, including the distribution of the patents, the application trends, the domestic and foreign geographical layout, the major applicant and its activity, the important technical areas, the important medicinal and its pharmacological properties and so on.
3.Profiling on the Invention Patents of Acanthopanax Senticosus
Yunyun MA ; Zhiyi SUN ; Haibo LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(11):2325-2330
A . Senticosus is a common medicinal plants, mainly used parts are the dried roots, rhizomes and stems. Since ancient time, it has been regarded as one of top grade medicabecause of its safety and various medicinal properties. To further the development and utilization, a survey of patent information is very helpful to outline the current status of the drug. In this paper, Espacenetand World Traditional Medcine Patent Database were used to perform patent retrieval. Then the dataset were screened, standardized and analyzes via Python and R. The result indicates that, A . Senticosus, given being used for a long history, has less invention patents application comparing with other TCM drugs. The applications mainly come from China, Korea, Japan, Russia, and USA. The major functions includes systemic protection, anti-toxic agent, and treatments of nervous system, digestive system, metabolic, immune and allergic diseases. As to the compatibility of medicines, it often associated with tonic medicine, especially Buqi medicine.
4.Schisandra Related Patent Development and Landscape Analysis
Yunyun MA ; Zhiyi SUN ; Haibo LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(9):1885-1890
Schisandra is a frequent traditional Chinese medicine. It has the efficacy of SHOULIAN-GUSE, YIQING-SHENGJING, tonifying kidney and Ning heart, is very important tonic medicine. Patent literature records the majority of technological innovations, is a kind of valuable scientific literature, making good use of it can effectively promote innovation. And invention patent is the most valuable of all patent. Access to information found that there is no paper about analysis of schisandra related pantent in China. Thus, in this paper, Schisandra related patents were collected, statistics, analysis, to discover the information within, such as Schisandra patent history, the current pattern, outstanding invention agencies and drug law of Schisandra. Based on the result above, we hope to provide a reference for the patent application.
5.Traditional Medicines Patent Information Analysis on Antidepressant
Yunyun MA ; Zhiyi SUN ; Haibo LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(8):1703-1707
Depression is a common mental disorders, severe cases may affect people's lives. In the treatment of de-pression, appropriate medication, as an assistant approach to psychological support, is proved helpful to patients' re-covery. Western medicine's ingredients are simple and mechanism is clear. Given it meets parts of the demand, the total effect is not satisfactory yet. Traditional Medicine's advantage is systematic, it has advantage in treating complex diseases. Thus, more and more attention was paid to Traditional Medicine, especially Traditional Chinese Medicine (TCM). In this paper, we use patent as data source to discover the law of the TCM's usage, the international differ-ences, the outstanding organization, and the hotspots of the drug research in the treatment of depression. Profiling of the current status can provide references in new drug finding and the progress of pharmacy. The results show that there are a few traditional Chinese medicine patents about treatment of depression associated with kidney, but de-pression and kidney also have a higher correlation. Medicines within soothing liver formulas such as Xiaoyaosan have many related patent.
6.Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro
Shuqin ZHANG ; Zhiyi LIU ; Fuming ZHANG ; Fei SUN
Journal of Jilin University(Medicine Edition) 2006;0(04):-
Objective To study the development of Arbidol hydrochloride(Ahyd) multi-layers controlled-released preparation and evaluate its release rate in order to provide the basis for Ahyd pharmacodynamics reseach.Methods Ahyd multi-layers was used as experiment group and Ahyd single-layer as control,high performance liquid chromatography(HPLC) was used to examine releasing level of two groups for calculating parameters of drug metabolism and bioavailability.Results Compared with Ahyd single-layer,the multi-layers controlled-released preparation had several significant advantages as below:Cmax fell remarkably(P
7.Determinants Factors of Arterial Elasticity in Normotensive Young Adults
Lin ZHOU ; Yuanyuan CHEN ; Xirong LIU ; Zhiyi MA ; Ningling SUN
Chinese Journal of Hypertension 2006;0(08):-
Objective To investigate the vascular compliance markers (C1 and C2) and pulse wave velocity in relative with other physiological indexes in a cohort of young normotensive people in Beijing. Methods Two hundred and seventy normotensive volunteers (112 men and 158 women aged 16 to 30 years) were invovled,completed questionnaires of demographic information. Large (C1) and small (C2) arterial compliance were derived from arterial pulse wave contour analysis. Pulse wave velocity(carotid-femoral PWV and carotid-radial PWV)was determined by Complior SP. Results In both male and female C1 correlated positively with height and weight,and negatively with systolic(SBP),mean arterial blood pressure(MAP),pulse pressure(PP),and heart rate(HR),in which PP showed the best correlation with C1;C2 was inversely related with SBP,diastolic blood pressure(DBP),MAP and HR,in which SBP showed the best correlation with C2;cfPWV correlated positively with DBP and age,crPWV correlated positively with age,DBP,height and weight. Conclusion Blood pressure,heart rate were the important influential factors of large and small arterial compliance in both males and females,while diastolic blood pressure was determinant for pulse wave velocity.
8.Thyroid diseases and cerebrovascular diseases
Xiaolu SUN ; Jinyu WANG ; Fang LIU ; Zhiyi HE
International Journal of Cerebrovascular Diseases 2016;24(3):284-288
The relationship between thyroid diseases and cerebrovascular diseases is getting increasingly attention. Studies have shown that thyroid diseases are associated with many kinds of cerebrovascular diseases, such as ischemic cerebrovascular disease, moyamoya disease, cerebral venous thrombosis, and artery dissection. This article review the advances in research on the correlation between thyroid diseases and cerebrovascular diseases.
10.Analysis on the Invention Patent of Traditional Medicines about Type-2 Diabetes Mellitus
Wenting WAN ; Yunyun MA ; Lijia XU ; Zhiyi SUN ; Haibo LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(6):1240-1245
In this paper, the patent of traditional medicines of type-2 diabetes mellitus before 2014 were searched, totally 1 229 patent family information were obtained. The patent information including developing trends, geographic distribution, competitive agencies, technical focus, herbs preferences and so on were analyzed. China is in a leader position on the number of applying patent of using traditional medicine to treat type-2 diabetes mellitus, and the main applications were research institutes, universities and pharmaceutical enterprises. Although the views and theo-ries on treatment of type-2 diabetes mellitus are variety and abound, the most frequently used traditional medicines are tonics and heat-clearing. This article reflected the history, clinical treatment way, developments, application of the diabetes traditional drugs after a meta-analysis,efforts to guide a better understanding and further research.