Objective To investigate the effect of 6 sigma nursing quality management model in rescue of patients with severe trauma.Methods According to the admission sequence,268 patients with severe trauma were selected as control group and treated with traditional first aid pattern; another 292 with severe trauma were chosen as the observation group and treated with 6 sigma nursing management mode(definition,measure,analysis,improvement and control).The two groups were compared in terms of rescue success rate and effective rescue time.Result The rescue success rate in the observation group was significantly higher than that in the control group and the effective rescue time in the observation group was significantly shorter than that in control group(P<0.05). Conclusion The application of 6 sigma nursing management mode in rescue of patients with severe trauma can improve the success rate,shorten the effective rescue time,so it enhances the nursing quality of severe trauma.