1.Salivary glands damnification after radiotherapy in patients with head and neck neoplasms
Journal of International Oncology 2011;38(3):198-200
Salivary gland damnification is one of the most common complication in head and neck cancer radiotherapy.Because of their unique anatomical positions,salivary glands usually receive high irradiation dose.Studies on radiation damage and dysfunction of salivary glands include injury mechanisms,relationship between dosimetrics and volumn changes and secretion,as well as prevention and treatment of damage.
2.Effect of GBE50 on L-type calcium current and cytosolic[Ca~(2+)]_i in ischemic guinea pig ventricular myocytes
Chinese Pharmacological Bulletin 2010;26(3):329-333
Aim To observe the effect of Ginkgo biloba extract 50(GBE50)on L-type calcium current and cytosolic[Ca~(2+)]_i in ischemic guinea pig ventricular myocytes.Methods Single ventricular myocytes were isolated by enzymatic dissociation. I Ca-L was recorded by whole-cell patch clamp technique in voltage clamp mode.[Ca~(2+)]_i was detected by laser confocal micros-copy and represented by relative fluorescent intensity (FI).Results During ischemia, the peak Ca~(2+) current was reduced, and the I-U curve of I Ca-L was shifted upward.50 mg·L~(-1) GBE50 reversed the change induced by ischemia(n =6, P >0.05).After perfusing ischemic solution for 12 min, intracellular calcium concentration was increased(n =10, P <0.01).After perfusion with ischemic solution containing 50 mg·L~(-1) GBE50, the increase of intracellular calcium concentration was markedly inhibited(n =10, P >0.05).Conclusion GBE50 can reverse the decrease of I Ca-L and partially inhibit calcium overloading during ischemia.
3.Observations on the Efficacy of Auricular Plaster Therapy for Depression in Newly Diagnosed Type 2 Diabetes
Fuqun LIU ; Jingjiao CHEN ; Zhixiong ZHANG
Shanghai Journal of Acupuncture and Moxibustion 2016;35(9):1073-1076
Objective To investigate the clinical efficacy of auricular plaster therapy for depression in newly diagnosed type 2 diabetes.Methods Sixty patients with depression in newly diagnosed type 2 diabetes were randomly allocated to group A of 18 cases, broup B of 22 cases and group C of 20cases. In addition to conventional hypoglycemic treatment, group A received psychological intervention; group B, auricular plaster therapy; group C, oral administration of fluoxetine hydrochloride capsules. Pre-/post-treatment changes in fasting blood glucose, two-hour postprandial blood glucose, glycosylated hemoglobin and the Hamilton Depression Scale (HAMD) score were observed in the three groups after eight weeks of treatment. The clinical therapeutic effects were compared between the three groups.Results There were no statistically significant post-treatment differences in fasting blood glucose, two-hour postprandial blood glucose and glycosylated hemoglobin among the three groups (P>0.05). There was a statistically significant pre-/post-treatment difference in the HAMD score in the three groups (P<0.05). There was a statistically significant difference in the HAMD score between groups B and A at two, four, six and eight weeks after treatment (P<0.05), between groups B and C at two weeks after treatment (P<0.05) and between groups C and A at two, six and eight weeks after treatment (P<0.05). The total efficacy rate was 77.8% in group A, 90.9% in group B and 90.0% in the control group. There was a statistically significant difference in the total efficacy rate between group B or C and group A (P<0.05).Conclusion Auricular plaster therapy plus medication is an effective way to treat depression in newly diagnosed type 2 diabetes.
4.Effects of Wound Treatment Methods on Residual Ovarian Reserve Function after Laparoscopic Ovarian Cystectomy
Zhenhua LIU ; Xinzhen MEI ; Zhixiong CAO
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2015;(6):722-724
Objective To investigate the influence of wound treatment methods on residual ovarian reserve function after laparoscopic ovarian cystectomy.Methods A total of 120 patients with ovarian cyst who underwent laparoscopic ovarian cystec‐tomy in the hospital were randomly divided into three groups in terms of different wound treatment methods:electric coagulation group ,ultrasound group and suture group ,with 40 cases in each group.The levels of follicle stimulating hormone(FSH) ,luteini‐zing hormone(LH) ,and estradiol(E2 ) were detected in the blood before and immediately after the operation ,2 days after men‐struation at postoperative 3 and 6 months ,and the number of ovarian reserve follicles determined by transvaginal ultra‐sound.The changes of menstruation and clinical manifestations of the patients were recorded at the same time.Results The lev‐els of LH ,E2 and FSH were dramatically changed in electric coagulation group ,which was followed by the ultrasonic group.Patients in the suture group had the smallest changes of these indices and recovered quickly(P<0.05).In the electric co‐agulation group relative to the other two groups ,the number of ovarian reserve follicles was significantly decreased and the inci‐dence of adverse reactions was profoundly increased.Conclusion Electric coagulation greatly adversely affects the residual ovar‐ian reserve function after laparoscopic ovarian cystectomy ,and ultrasonic and suture hemostasis techniques can help to protect o‐varian function.
5.Effects of Ginkgo biloba extract 50 preconditioning on contents of inflammation-related cytokines in myocardium of rats with ischemia-reperfusion injury.
Yimin BAO ; Aihua LIU ; Zhixiong ZHANG ; Yun LI ; Xingyu WANG
Journal of Integrative Medicine 2010;8(4):373-8
Objective: To investigate the effects of Ginkgo biloba extract 50 (GBE50) preconditioning on contents of inflammation-related cytokines in rats with myocardial ischemia-reperfusion. Methods: Fifty-eight SD rats were divided into sham-operated group, untreated group, Salviae miltiorrhizae (SM) injection group and low-, medium- and high-dose GBE50 groups. After intragastric administration for 7 d, the left anterior descending (LAD) coronary artery was occluded for 30 min followed by 60-min reperfusion to induce ischemia-reperfuion injury. Myocardium histopathologic change was observed by HE staining under a light microscope; myeloperoxidase (MPO) activity in myocardium was measured by colorimetric detection; tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-8 were detected by radioimmunoassay; IL-4 and IL-10 were tested by enzyme-linked immunosorbent assay (ELISA). Results: Compared with untreated group, rats in medium-dose GBE50 group had lower inflammatory reaction and MPO activity (P<0.01). GBE50 also decreased the content of IL-6 (P<0.05, P<0.01) and increased the content of IL-4 in myocardium (P<0.05, P<0.01) as compared with the untreated group. The content of TNF-alpha in myocardium in the medium-dose GBE50 group was lower and IL-10 was higher than those in the untreated group, but without significant differences. Conclusion: GBE50 can decrease the content of IL-6 and increase the content of IL-4 in myocardium after ischemia-reperfusion injury. It suggests that GBE50 can regulate the inflammatory reaction after ischemia-reperfusion injury via inhibiting inflammatory cytokines and promoting anti-inflammatory cytokines.
6.Surgical treatment of spinal tuberculosis in older patients
Wen LI ; Zhixiong LIN ; Qi LIU ; Weijie LU ; Nansheng YU
Chinese Journal of Orthopaedics 2011;31(1):55-60
Objective To discuss perioperative features, operative approach and surgical effects of spinal tuberculosis in older patients. Methods Retrospective analysis was conducted to analyze the clinical data of 45 patients with spinal tuberculosis ranging in age from 61 to 78 years (average, 67 years). The lesion was located in thoracic vertebrae in 9 patients, thoracolumbar vertebrae in 14, lumbar in 16, and lumbosacral in 6. Preoperative Frankel grades were B in 7 cases, C in 21, D in 11 and E in 6. Among them, 21 had cardio-cerebrovascular disease, 10 had diabetes mellitus. With preoperative medicine and chemotherapy for 2-3 weeks, all patients were treated surgically. The surgical procedures included: 1) Posterior focus debridement, bone grafting and one-stage posterior transpedicular screw system fixation in thoracic vertebrae (T2-T7). 2) Anterior debridement, bone grafting and one-stage posterior transpedicular instrumental fixation in lumbosacral vertebrae (L5-S1). 3) Anterior focus elimination, bone grafting and one-stage anterior plate fixation in the other vertebrae. Results Forty-five patients were followed up for 24 to 40 months, with the average of 28.5 months. No severe complication occurred during and after operation. Forty-four cases had recovered and 1 recurred. Spinal fusion occurred 12-18 months after operation. Frankel neurological grades improved significantly. Conclusion With the effective management of comorbidities in perioperative period,the elderly could tolerate surgical treatment. The appropriate approaches, thorough debridement and reasonable bone grafting with internal fixation are key to therapeutic success.
7.Therapeutic effect of balloon catheter dilatation with ice water on cricopharyngeal achalasia
Juan YANG ; Yinjin SHAO ; Zhixiong XU ; Zhihong LIU ; Ping ZHONG
Chinese Journal of Physical Medicine and Rehabilitation 2014;36(5):363-366
Objective To observe the therapeutic effects of balloon dilatation with ice water and room temperature water on cricopharyngeal achalasia after brainstem stroke.Methods Forty dysphagic patients with cricopharyngeal achalasia after brainstem stroke were recruited.Twenty patients assigned to experimental group were treated by balloon dilatation with ice water and low frequency elecrtrical stimulation.Twenty patients assigned to control group were treated by balloon dilatation with room temperature water and low frequency electrical stimulation.Results After treatment,36 out of the 40 patients of the two groups could eat pasty food independently without choking.Videofluoroscopic swallowing study (VFSS) showed that the cricopharyngeal sphincter relaxed and the foods passed successfully when swallowing bolus,and no aspiration happened.In comparison,the level of cricopharyngeal opening,the number of patients with nasogastric tube remained and eating normally,and the scores of functional oral intake scale (FOIS) between the two groups showed no significant difference (P > 0.05).The average treatment sessions,average hospitalization days and average treatment cost in treatment group were significantly less than those in the control group(P <0.05).Conclusion Cricopharyngeal achalasia can be treated effectively by balloon dilatation with ice water or with room temperature water combined with low frequency electrical stimulation,but treatment course of balloon dilatation with ice water were significantly shorter than that of balloon dilatation with room temperature water.
8.Determination of Icariin Content in Qianlie Shule Granule by HPLC
Hongfei CAI ; Youheng GAO ; Jun LIU ; Honghua CUI ; Zhixiong WEI
Traditional Chinese Drug Research & Clinical Pharmacology 1993;0(04):-
Objective To determine the icariin content in Qianlie Shule Granules (QSG). Methods After proper pre-treatment,HPLC method was performed on a C18 column. The mobile phase consisted of acetonitrile-water (29 ∶71) and the UV d etective wavelength was set at 270 nm. Results The peak of icariin was separated completely. The calibration curve of icariin was linear within 0.16~1.2 mg?mL -1,Y=0.028 7X-0.009 62 (r=0.999 9). Conclusion This method is accurate and su itable for the determination of icariin content.
9.Neuronavigator-assisted microsurgical resection of glioma located in cerebral functional areas
Guohui SU ; Zhixiong LIU ; Lei HUO ; Chuntao LI ; Mingyu ZHANG
Journal of Central South University(Medical Sciences) 2017;42(5):542-545
Objective:To evaluate value of neuronavigator-assisted microsurgery of glioma located in cerebral functional areas.Methods:Patients with glioma located in cerebral functional areas were underwent operation in Xiangya Hospital.Of 64 patients,34 patients were performed neuronavigator-assisted microsurgery,and 30 were underwent routine surgical operation.Results:The neuronavigator-assisted microsurgery group showed high complete resection rate with low neurological deficit and cerebral edema compared with the routine surgical group (P<0.05).Conclusion:Neuronavigator-assisted microsurgery is effective and characterized by accurate location,personalized operative incision design,and higher rate of tumor resection.
10.The Effect of Traditional Culture on the Development of Traditional Chinese Medicine and the Measures of Strengthening the Cultivation of Humanistic Spirit
Pinghua SUN ; Lian LIU ; Zhixiong ZHAO ; Jing LIN ; Jialiang GUO
Chinese Medical Ethics 2017;30(6):697-700
Chinese traditional culture is the soil for the survival and development of traditional Chinese medi-cine,among them,the concept of A thing is valued if it is rare portal factions and master has influenced the development,communication and popularization of traditional Chinese medicine.But the spirit and thinking of harmony unity of heaven and man comparative state benevolence and self-cultivation and self-re-straint has played an active role in the development of traditional Chinese medicine.Thus this paper put forward the suggestions and opinions of strengthening the cultivation of humanistic spirit of higher traditional Chinese medi-cine talents:establishing a comprehensive evaluation standards of higher traditional Chinese medicine talents,es-tablishing scientific development concept to treat the inheritance and innovation of traditional Chinese medicine cul-ture,perfecting the curriculum provision of relevant professions,creating the conducive environment for the trans-mission of traditional Chinese medicine culture,hoping to provide a reference for the explanation of the relationship between traditional culture and traditional Chinese medicine.