1.Diagnosis and treatment of neonatal hypoglycemia
Journal of Clinical Pediatrics 2010;(3):212-214,219
Neonatal hypoglycemia is a common metabolic problem. The definition and clinical management of neonatal hypoglycemia remains controversial. The concerned reasons are mainly as follows:the course of a physiological decrease and recovery in the level of blood glucose is usually existed in newborn infants after birth;asymptomatic hypoglycemia(many newborn infants' blood glucose level is very low but without any clinical signs or symptoms);and the lack of the complete comprehension for the relationship between neonatal hypoglycemia and the long-term neurologic prognosis. The review describes the etiology,definition and clinical management of hypoglycemia in newborn infants.
2.Present perceptions and trends of surgical margin in soft tissue sarcoma in limbs and trunk
Chinese Journal of Clinical Oncology 2017;44(1):2-6
Limb salvage surgery with comprehensive treatment is the standard care for soft tissue sarcoma in the limbs and trunk. Marginal status is a key factor in determining the quality of surgical treatment, as well as in guiding the selection of adjuvant therapies. The goal of surgery is to obtain an appropriately negative margin, although no consensus exists regarding the adequate thickness of normal tissue cuff. With the development of auxiliary treatments, surgery for soft tissue sarcoma is becoming less extensive. Marginal resection combined with adjuvant therapies may be necessary to preserve limb functions when the tumor is close to critical vessels, nerves, or bones. When preparing the preoperative plans, additional considerations should include histologic type, location, presence of barriers, and response to adjuvant therapies.
3.The research development of LncRNA in colerectal cancer
Practical Oncology Journal 2015;(4):355-358
With the progress of genetic studies,it has been found that long non-coding RNA( LncRNA) in many regulations which play a key role in development of tumor.Its own individual pieces can also have differ-ent adjustive effects;some LncRNA can even have different regulation and controlling effect in a variety of tumor. How the newly discovered LncRNA expression in colorectal cancer?This review mainly outlines the research de-velopment of LncRNA in colerectal cancer in brief.
4.Full-range control model of clinical blood use - Establishment and operation
Chinese Journal of Hospital Administration 2010;26(7):518-520
The medical order number of a blood transfusion is used as the matching number in the full range of clinical blood use. A cycle is built ranging from the application for to the implementation of a medical order for blood transfusion. Such measures as repeated blood types verification by two departments, dual-database management of blood type files, and bar coding are called into play to ensure information correctness. These measures can make sure that the correct blood type is transfused to the correct patient and rule out accidents in blood transfusion. Indications for blood products are set up under real-time surveillance, which makes available limited blood products supply to those in need and minimizes waste and abuse of such products. The full-range and real-time management of clinical blood use will confine blood transfusion indications and ensure patients' safety with 100% match ratio.
5.Effect of numerical simulation of vascular wall thickness on fluid-structure interaction analysis of complex intracranial aneurysms
Chinese Journal of Tissue Engineering Research 2014;(11):1765-1773
BACKGROUND:Intracranial aneurysms have a high mortality, and finite element analysis to predict fracture risk has become a hot topic at present. Finite element analysis requires reliable fluid-structure interaction model, blood model of aneurysm is very easy to obtain, but the vascular wal model can not be obtained directly, only by artificial settings, which may have an impact on calculation results.
OBJECTIVE:To investigate the effects of vascular wal thickness on fluid-structure interaction analysis in finite element modeling of complex intracranial aneurysms, and provide a more reliable method of finite element modeling for the numerical simulation study of intracranial aneurysms.
METHODS:A three-dimensional numerical model of tandem left intracranial internal carotid artery aneurysms of a 67-year-old man was obtained by three-dimensional angiography. Four fluid-structure models were got postoperatively by thickening vascular wal , which were artificial y set for 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm. According to intraoperative measured data, dynamic characteristics of fluid-structure interaction of tandem internal carotid artery aneurysms were simulated by the finite element method, comparing four models to calculate the difference between the results.
RESULTS AND CONCLUSION:Among the four models, there were no difference in blood flow chart, blood pressure drop chart and wal shear stress chart (P>0.05). The deformation of the vascular wal was the most obvious in C 2 segment of the internal carotid artery, and the thicker vessel wal was accompanied by the more apparent deformation (P<0.01). Von Mises stress in the vessel wal of the four models reached a local maximum in the I and J points, the thinner vessel wal was accompanied by the larger local maximum (P<0.01). The settings of vascular wel may affect the fluid-structure interaction analysis of complex intracranial aneurysms and appropriate thickness settings wil obtain accurate calculation.
6.Current application of sentinel lymph node biopsy in cutaneous malignant melanoma
Chinese Journal of Clinical Oncology 2014;(12):810-813
Sentinel lymph node biopsy has a very important function in the accurate staging, diagnosis, and treatment of malig-nant melanoma. The operational technique of sentinel lymph node biopsy (SLNB) has been basically mature, but its indications remain unclear, especially for thin melanomas. Adequate evidence to show that SLNB combined with a complete lymph node dissection can prolong the survival of patients with metastasis is unavailable. Given the low incidence of malignant melanoma in the country, the use of SLNB has not been extensively investigated in China and the relevant methods are outdated. This review summarizes the current ap-plication of SLNB in cutaneous malignant melanoma by analyzing related studies conducted in recent years.
7.Expression and role of IL-33 and its receptor ST2 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps.
Tiancong LIU ; Changlong LV ; Zhiwei CAO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(15):1350-1371
OBJECTIVE:
To investigate the expression and role of Interleukin-33 (IL-33) and ST2 in the nasal polyps of human Eosinophilic and non-Eosinophilic chronic rhinosinusitis with nasal polyps (ECRS and non-ECRS).
METHOD:
IL-33 and ST2 protein expression in nasal polyps of ECRS and non-ECRS as well as in seemingly normal mucosa of the inferior turbinate tissue was investigated by immunohistochemical staining and messenger RNA (mRNA) expression of IL-33 and ST2 was assessed by realtime polymerase chain reaction (PCR) in 27 subjects with ECRS, 33 subjects with non-ECRS, and 11 control subjects.
RESULT:
(1) The ST2 was found both in nasal polyps of ECRS and non-ECRS,especially in ECRS, yet hardly found in the normal mucosa of the inferior turbinate tissue; (2) The expression of ST2 mRNA in nasal polyps of ECRS was higher than that in non-ECRS and normal inferior turbinate tissue, and the difference was both prominent in statistics (P<0.01); (3) The expression patterns of IL-33 at both mRNA and protein levels were not significantly different among the three groups (P>0.05).
CONCLUSION
The IL-33 and its receptor ST2 were both expressed in human nasal polyps including ECRS and non-ECRS, meanwhile the expression patterns of ST2 at both mRNA and protein levels were significantly higher in nasal polyps of ECRS. The current study suggests that IL-33 and its receptor ST2 may play important roles in the pathogenesis of chronic rhinosinusitis with nasal polyps, especially in ECRS through the increased expression of ST2 in Eosinophils as a hypothesis.
Chronic Disease
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Eosinophils
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immunology
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Humans
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Interleukin-1 Receptor-Like 1 Protein
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Interleukin-33
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metabolism
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Nasal Mucosa
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metabolism
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Nasal Polyps
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immunology
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RNA, Messenger
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Real-Time Polymerase Chain Reaction
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Receptors, Cell Surface
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metabolism
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Rhinitis
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immunology
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Sinusitis
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immunology
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Turbinates
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metabolism
8.Expression and clinical significance of Eotaxin-3 in chronic rhinosinusitis with and without nasal polyps.
Meng LIU ; He ZHAO ; Zhiwei CAO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2016;30(3):190-193
OBJECTIVE:
To investigate the expression and clinical significance of Eotaxin-3 in chronic rhinosinusitis with and without nasal polyps.
METHOD:
The ethmoid inflammation mucosa of 15 cases diagnosed as chronic rhinosinusitis (sinusitis group), the nasal polyps in the middle meatus of 25 cases diagnosed as nasal polyps (nasal polyp group) and the ethmoid or uncinate process mucosa of 7 cases diagnosed as sinonasal non-inflamnatory diseases (control group), were collected as the research object. Eotaxin-3 expression was detected in the tissues by immunohistochemical SABC assay and the correlation between Eotaxin-3 and blood eosinophil counts was analyzed.
RESULT:
Eotaxin-3 were detected both in sinusitis group and nasal polyp group, and the expression level in sinusitis group and nasal polyp group were higher than that in control group. The difference was statistically significant (P < 0.05). The Eotaxin-3 expression in nasal polyps group was higher than that in sinusitis group, and the difference was statistically significant (P < 0.05). The expression of Eotaxin-3 in nasal polyps group and sinusitis group were both significantly positively correlated with the eosinophil counts in the blood (P < 0.05).
CONCLUSION
Eotaxin-3 may be involved,in the pathogenesis of chronic rhinosinusitis with and without nasal polyps, and further research will help us to understand the pathophysiology of chronic rhinosinusitis with and without nasal polyps.
Chemokine CCL26
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Chemokines, CC
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metabolism
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Chronic Disease
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Eosinophils
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Ethmoid Sinus
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pathology
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Humans
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Mucous Membrane
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pathology
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Nasal Polyps
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metabolism
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pathology
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Rhinitis
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metabolism
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pathology
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Sinusitis
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metabolism
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pathology
9.Interventional drainage through sinus tracts for the treatment of postoperative abdominal abscess
Shouwang CAI ; Zhiwei LIU ; Ningxin ZHOU
Medical Journal of Chinese People's Liberation Army 2001;0(09):-
Objective To explore a new way to drain a postoperative abdominal abscess. Method Drainage catheter and sinography were employed to locate the site of the abscess, and a 10.2F~16F catheter with single or double lumen was inserted into the abscess by interventional technique. Result A 100% success was obtained for the 15 patients with 18 abscesses by inserting the drainage catheters, and all the abscesses were cured 7~65 days after drainage. Conclusions Compared with the surgical or percutaneous drainage, the present method is less traumatic, safer, more economical and effective, and it could be applies to all kinds of postoperative intraperitoneal abscesses which could not been drained adequately or with formation of sinus because of displacement of drainage tube.
10.Comparison of Serum Levels of Thyroid Hormones and Thyroid-Stimulating Hormone in Excess-Heat and Deficiency-Heat Patients
Qun CHEN ; Zhiwei XU ; Yamei LIU
Journal of Guangzhou University of Traditional Chinese Medicine 2001;0(03):-
[Objective] To investigate the relationship of thyroid hormones with excess-heat syndrome and deficiency-heat syndrome. [Methods] Serum levels of thyroid hormones and thyroid-stimulating hormone (TSH) in 30 healthy volunteers (Group A) , 27 cases of excess-heat syndrome (Group B) and 35 cases of deficiency-heat syndrome (Group C) were detected by radioimmunoassay. [Results] Serum levels of triiodothyronine (T3) and thyroxine (T4) were higher and reverse T3 (rT3) lower in Group C than those in Group A (P 0.05). [Conclusion] Serum thyroid hormones level in deficiency-heat syndrome is different from that of excess-heat syndrome may be related to the hypothalamus-pituitary-thyroid function.