Objective To observe the clinical effect of controlled ventilation with i-gel laryngeal mask airway in painless bronchoscopy. Methods 80 patients were randomly divided into control group (group A, n =40) and surface anesthesia group (group B, n = 40). Fent-anyl, ruifentanyl, propofol, succinylcholine anesthesia and controlled ventilation was adopted by i-gel laryngeal mask combined with T-seal adapter in control group.Surface of lidocaine anesthesia, spontaneous breathing, nasal cannula oxygen were applied in surface anesthesia group. Patients vital signs change in bronchoscopy , endoscopic related adverse reactions such as body movement, cough, laryngospasm. anesthesia related adverse reactions such as postoperative bucking, choking hoarseness, examination time and patient satisfaction were recorded. Results Controlled ventilation with i- gel laryngeal mask shows airway changes are small (P < 0.05), and less adverse reaction (P < 0.05). Patients showed higher satisfaction (P < 0.05). Conclusion controlled ventilation with i-gel laryngeal mask in painless bronchoscopy is safe , controls the airwayeffectively , and solve the problem of respiratory depression , which proves to be a feasible method.

Most of the anticancer drugs have some limitations in clinical application,such as poor solubility,low targeting and cytotoxicity to normal tissue and organ.The application of drug carriers offers a solution of these problems to a certain extent.In recent years,some materials such as polymers,liposomes,carbon nanotubes (CNTs) were used as carriers of anticancer drugs.The utilization of these carriers improved drug targeting and reduced adverse reactions by targeted modification of carriers which ensured the slow release of the drugs and maintained the plasma concentration.In these carriers,CNTs,as a novel nano-material,have attracted more attention in nanomedical applications.CNTs not only possess nanoscaled diameter,hollow structure and large aspect ratio,resulting in large drug capacity,but also can selectively absorb near infrared lights and transform them into thermal energy,according to the research finding.The functionalized drug-loaded CNTs in combination with thermotherapy shows potential,which is expected to become a new targeting therapy of cancer.In this paper,the basic structure of CNTs,the application of CNTs as drug carriers,and the recent development of functionalized CNTs as drug carriers combined with thermotherapy in tumor therapy were summarized.