The MDA contents of platelet, plasma and lung tissue in rat endotoxemia were measured by TBA fluorescent method. It was showed that the lipid peroxidation of platelet and plasma was significantly increased, but there was no notable change of the lung tissue.

OBJECTIVE: To investigate the use of ?-receptor blockers,angiotensin converting enzyme inhibitors,aspirin and statins in acute myocardial infarction patients. METHODS: The general information of 119 cases of established acute myocardial infarction in 4 hospitals in Jiangbei district of Chongqing between 1999 to 2004 were analyzed retrospectively. RESULTS: The suitable use rates of ?-receptor blocker and angiotensin converting enzyme inhibitor are 79.0% and 85.7%, respectively, while their actual rates were 35.3% and 43.7%,respectively. Therefore among the suitable patients,55.3% of them did not receive the treatment with ?-receptor blockers and 49.0% did not take angiotensin converting enzyme inhibitors properly. The use rate of aspirin was high to 84.9%. The statins was not used until 2002 and its use rate was 15.1%. CONCLUSION: There exists significant gap between the practice and the requirement in“diagnositic and therapeutic guide for acute myocardial infarction” in the use of these drugs, except the aspirin. However, this situation is being changed.

Objective To assess the modified two-window ilioinguinal approaches used for the open reduction and internal fixation of anterior wall/column fractures of acetabulum.Methods From March 2011 to March 2012,we treated 15 patients with anterior acetabular fractures by open reduction and internal fixation.They were 13 males and 2 females,18 to 53 years of age (mean,36.8 years).According to Judet & Letournel classification,we had 6 anterior column fractures,3 transverse plus posterior wall fractures 6 double column fractures.The anterior wall/column fractures were reduced and fixated using plates and screws through 2 separate small incisions located on the symphysis pubis and the posterior part of iliac crest,respectively.The posterior components of the acetabular fractures were reduced and fixated by the Kocher-Langenbeck(K-L) approach.Only the modified two-window approaches were used for 6 anterior column fractures,and the other 9 cases used the K-L approach in addition to the modified two-window approaches.The operation time,intra-operative blood loss and postoperative complications were recorded.The quality of fracture reduction was judged according to the Matta scheme and the clinical outcome was measured using the Merle d' Aubigné-Postel rating system.Results All the 15 patients were followed for an average of 15 months (from 9 to 19 months).The mean operation time for the 15 patients was 223.3 ±85.8 minutes and the intra-operative blood loss averaged 993.3 ± 416.6 mL.Anatomical reduction was achieved in all the patients according to the Matta scheme.Lateral femoral cutaneous nerve palsy was observed in one patient but recovered spontaneously one month after operation.The mean Merle d'Aubigné-Postel score at the last follow-up was 16.9 points (from 14 to 18 points).The outcome was defined as excellent in 6 patients,good in 8 and fair in one.No more complication was observed during the follow-up period.Conclusions The modified two-window ilioinguinal approaches can be used for satisfactory reduction and fixation of the anterior wall/column or the anterior components of acetabular fractures.In addition,the modified approaches do not invade very much the soft tissues or need to expose the femoral vessels and nerves.

With the increasingly deepening research on the molecular regulatory mechanisms during the development and progres-sion of advanced renal cell carcinoma, the targeted therapy directed on the key proteinase/protein in the molecular signaling pathways significantly improves the management outcomes. However, the occurring resistance during therapy with targeted agents leads to de-creasing effects. The mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma are simply reviewed.

The endotoxemia model was established by intraabdominal injection of endotoxin Coli B. (E. Coli O55B5,8 mg/kg weight)in albino rats. Two hours before administration of endotoxin, the ejiao recovery-pulse decoction was perfused into the stomach tube of the rats in the experimental group (10mg/kg weight), and 12h later, the platelets were counted, kaolin activated partial thromboplastin time (KPTT), prothrombin time (PT) and thrombin time (TT) were measured, and malondialdehyed (MDA) levels in plasma and platelet were determined by thiobarituric acid (TBA) fluorometry. The results demonstrate that the ejiao recovery-pulse decoction could prevent from peripheral platelet dropping, KPTT and TT prolonging and MDA level rising which were caused by endotoxin.

In this study, endogenous digoxin-like substance (EDLS) in the plasma was measured by radioimmunoassay in patients with congestive heart failure The EDLS levels were significantly increased in patients with heart failure and were positively correlated correlated with the heart function state, Na~+/K~+-ATPasc activity in red cells and the electrolyte change in blood cells. We believed that digoxin-like substance may participatc in the process of the compensatory mechanirsms of the heart failure.

The sonographie diagnosis of suhcutaneoyus nodules caused by lupg flukes in ten cases from the mountainous area of Xiangxi was reported.According to their ultrasonographic features,these nodules could be divided into three types:the substantial(one case),anechoic(two cases),and mixed type(seven cases).The sonographic characteristics,the pathotogic stages and the cytology of the subcutaneous nodules caused by lung fluke these cases were discussed.

Objective:To explore the process of maintenance management for large medical equipment, and the structure design and core connotation of the maintenance management software of them.Methods: Medical linear accelerator of Precise series of Elekta company was combined to achieve the objective. From the aim of designing normal operation rate to start, the failure mode and effects analysis (FMEA) was operated to analyze the maintenance strategies and maintenance manners which were established on the basis of PDCA(Plan, Do, Check, Action) cycle and the analysis mode of SWOT (Strength, Weakness, Opportunity, Threat), and it could achieve the aim of normal operation rate.Results: Through explored the connotation of maintenance management and the preliminary framework of the software of maintenance management, the detail and process of maintenance management that based on personalized accelerator of process control were established, and the element factors of software of maintenance management of accelerator also was established at the same time.Conclusion: The effective maintenance management of large medical equipment is based on informatization process management of process control, and the element factor of management software need personalized customization. On the other hand, failure mode and degradation mechanism of equipment were the basis for personalized customization, and the creation has practical value.

Objective To explore the relationship between perioperative serum thyroid hormone changes and heart dysfunction in patients undergone cardiac valve replacement. Methods The serum concentrations of free tri- iodothyronine (),free thyroxine (),total total reverse and thyroid-stimulating hor- mone (TSH) in 20 patients undergone routine rheumatic mitral valve replacement were determined by radioim- munoassay at preoperation, the end of myocardial ischemia, and 2,6,12,24 and 48h postoperation, respectively. The alteration hormones above mentioned were comparatively analysed of the normal heart function group (group I,n = 14) and heart dysfunction group (group I ,n=6) after surgery. ResultsIn comparing group I with group I , the more severe the chronic congestive heart failure, the lower the thyroid hormone level before operation;and subse- quently both progressively lowered T3 level and acute heart dysfunction emerged after operation. The decreased extent of serum thyroid hormone was closely parallel to the severity of heart dysfunction. GonclusionPerioperatively, de- creased serum FT3 and TT3 concentrations are at least an important humoral factor aggravating heart dysfunction, and the patients with preoperative low T3 should be considered as high-risk valvular surgical cases.

Objective:To discuss the maintenance and testing method, reduce CT machine fault, ensure the quality of CT machine performance, reduce the use of CT machine cost, increase the use value of CT machine,the better service for the masses and treatment.Methods:Using regular maintenance and inspection, specific Toshiba 64 row CT machine each time the content of maintenance and testing content.Results:Regular service and maintenance are the most effective CT machine performance quality guarantee the most basic method, can avoid 30% to 50% of the machine fault, not only greatly reduce the machine hardware damage failure incidence, software programs or data error of failure rates.Conclusion: The regular maintenance and maintenance is hotly debated in recent years the core content of preventive maintenance, periodic testing is an effective guarantee quality of CT machine performance of necessary measures, called on metrology institute and the centers for disease control and coordinated with the hospital, turn the two detection time about half a year, also accord with the national strong inspection requirements so that the rationality of the quality assurance, to avoid most of the repeated testing of national resources waste.