Objective To estimate the effect of Yiqi-Wenyang-Gujing decoction combined with the conventional western therapy on the elderly with chronic glomerulonephritis. Methods The 65 patients who conforming to the diagnostic criteria were randomly divided into the treatment group (33 patients) and control group (32 patients) according to the random number table. The control group was treated with the conventional western therapy, and the treatment group was treated with Yiqi-Wenyang-Gujing decoction based on the former treatment. After the treatment of 8 weeks, the curative effect of edema and the 24 hours urine protein and the changes of renal function were observed. Results Compare with the control group, the 24 hours urinary protein (0.8 ± 0.1 g vs. 1.3 ± 0.7 g, t=4.625), the SCr (132.0 ± 8.5μmol/L vs. 163.9 ± 6.2μmol/L, t=17.242) and the BUN (7.1 ± 2.2 mg/L vs. 9.2 ± 2.5 mg/L, t=3.598) of treatment group significantly decreased (P<0.01);The glomerular filtration rate of treatment group [(73.9 ± 4.2 ml/(min·1.73 m2) vs. 65.4 ± 2.4 ml/(min·1.73 m2), t=9.976] significantly increased (P<0.01). And the degree of edema was relieved more in the treatment group than that of the control group (P=0.049). The total effective rate of the treatment group was significantly better than that (78.8% vs. 46.9%, P=0.016) of the control group. Conclusion The combined Yiqi-Wenyang-Gujing decoction and western medicine treatment on the elderly with chronic glomerulonephritis could improve the kidney function and relieve edema.

AIM　To study the efffects and mechanisms of hetrazane（diethylcarbmazine citrate，DEC）on contraction of isolated tracheal strips of guinea pigs. METHODS　Using isolated tracheal strips technique. Each tracheal strip was placed in an organ bath filled with a Krebs solution of 37℃ and various drugs was added respectively. It was determined that KCl or 5-HT induced the contractile effects and its dose-response curve on tracheal strips and DEC or verapamil changed the effects of KCl or 5-HT. RESULTS　The contractions induced by KCl or 5-HT in isolated tracheal strips of guinea pig were markedly inhibited by DEC, the IC50 value of DEC for contraction induced by KCl and 5-HT was 5.03 mmol*L-1 and 9.54 mmol*L-1 respectively. DEC caused rightward displacement of the dose-response curse for KCl and 5-HT, and significantly depressed the maxmal response, showing anon-competitive antigonism, the pD′2 values were 1.554 and 1.851 respectively, and DEC markedly inhibited the contractions induced by Ca2+ released from an intracellular store and extracellular Ca2+. CONCLUSION　DEC can significantly inhibit contraction of tracheal strips induced by KCl and 5-HT, and its mechanism is responsible calcium-antagonistic effect of DEC.

Objective To investigate the continuous suture through the lower edge of the tarsal joint fixation orbital reconstructive eyelid superfluous skin treatment efficacy.Methods 50 cases of abject epicanthus clinical data were retrospectively analyzed from June 2009 to June 2013 in our hospital by the hospital ethics committee approved,which had a total of 100 eyes.According to the numbering method,they were randomly divided into control group and observation group,each 50 cases.Control group was given through the lower edge of the tarsal continuous suture fixation,while the observation group was treated on the basis of control group combined with joint orbital entire complex treatment.Therapeutic effects were compared,pain,treatment before and after each measurement indicators and lower eyelid skin complications and so on.Results After treatment,the control group redundant lower eyelid skin correction,eyelash contact with the cornea and corneal epithelial healing of eye damage were respectively 39 (78.00％),10 (20.00％) and 43 (86.00％),while the observation group were 49 (98.00％),1 (2.00％) and 50 (100.00％),the above parameters were statistically significant differences (x2 =5.559,16.839,3.840,P ＜ 0.05,P ＜ 0.01) ; According to VAS pain score,VAS scores before and after treatment were statistically significant (t =5.271,12.593,P ＜0.05,P ＜ 0.01),and the observation group after treatment VAS scores after treatment compared with the control group,the difference was statistically significant(t =4.399,P ＜ 0.05) ; Before and after treatment from the eyelid folds distance,flat as the lower eyelid away from the eye position,head lower eyelid skin flap in eyelid,head tilt eyelashes,inner canthal angle,outer canthal angle,inner canthal folds,palpebral fissure height,head of small tears on the pitch,orbicularis muscle eyelid width,eyelid orbicularis muscle thickness and orbital orbicularis muscle thickness differences were statistically significant,and the observation group after treatment with these indicators compared to the control group after treatment,the differences were statistically significant (t =4.292,5.828,4.135,5.099,4.723,5.002,6.717,8.092,7.038,8.056,3.129,7.043,P ＜ 0.05) ; the course of treatment in both groups would be lower eyelid retraction,ectropion and eyelid scar concurrent disease control group complication rate was 20.00％,which was significantly higher than that of the observation group(6.00％),the difference was significant statistical significance(x2 =13.283,P ＜ 0.01).Conclusion Over the lower edge of the tarsal joint continuous suture fixation treatment of orbital reconstructive eyelid superfluous skin effect is significant,with low complication rate,which is worth to be promoted in clinical and applied.

Forty—five patients with irritable bowel syndrome and 52 normal controls were assessed with theCoping Style Questionnaire.Compared with controls,male patients scored lower in three subscales of Asscrtion,RationalProcessing,and Control,but higher in the the subscales of Support Orientation,Emotional Processing,and Resignation.The score of Emotional Processing in female patients was significantly higher than that im female controis.The data sug- gested that there was difference in coping between IBS patients and normal controls,and between the male and female pa-tients.

With the thorough research on cognitive impairment in old age,vascular cognitive inpairment (VCI) has become a hot research field of neuroscience in recent years.Yet,the VCI-related pathogenic mechanism currently remains unknown.Therefore,the reliable and stable animal models are needed to reveal the pathogenesis and pathophysiologic changes of VCI in order to provide a theoretical basis for early warning,diagnosis and treatment of VCI.The commonly used animal models now have their own advantages and disadvantages,the results have greater differences.This article reviews the commonly used VCI animal models,related cognitive behavior changes,and change characteristics of histopathology in recent years,and the reasonable animal models of VCI according to different research objectives are investigated preliminarily.

Objective To investigate the effect of induced aborion on stage of labor and placental abnormality of primiparous women during parturition. Methods Birth process and abnormal placenta during labor for 74 women with a history of induced abortion (observation group) and 102 women without a history of induced abortion ( control group) in their first parities were collected and compared. Results The third stage of labor of the observation group was (10.75 ±2.64) min,longer than (8.12 ±3.26)min of the control group,the difference had statistical significance(P ＜0.05). The rate of placenta adhesion,placental remnants and low lying placenta of the observation group were 13.52%, 10.81% and 8.11% respectively, significantly higher than 2.95 %, 1.96% and 0.98% in the control group(P ＜0. 05). Conclusion It was demonstrated that induced aborion had obvious untoward effect on pregnancy such as prolonged third stage of labor and increased incidence of placental abnormalities. So, it was necessary to prevent induced aborion for primiparous women.

Coronary Stenosis ; diagnostic imaging ; Fractional Flow Reserve, Myocardial ; Humans ; Tomography, X-Ray Computed ; methods

Colorectal cancer is one of the most common malignant tumors. The recent successful development of targeted therapy has brought new hope for patients with colorectal cancer. Two monoclonal antibodies, bevacizumab and cetuximab, that block vascular endothelial growth factor and epithelial growth factor receptor are available widely in clinical practice. This clinical review focuses on the role of targeted therapy in the management of colorectal cancer.

AIM: To study mechanism of hepatocytic mitochondria damage following septic shock. METHODS: 30 SD rats were randomly divided into three groups: sham operation group, 12 h cecal ligation and puncture (CLP) group and 16 h CLP group. The model of septic shock was made by cecal ligation and puncture. The liver mitochondria respiratory control rate (RCR), phosphate/oxygen (P/O) and ATPase activities were assayed. RESULTS: In 12 h CLP group mean artery pressure (MAP) [(9.54?1.26) kPa] was significantly lower than sham operation group [(14.58?1.32) kPa, P

AIM: To study the protective effect of ci stanche deserticola Y. C Ma. on thymocytes in septic rats. METHODS: Cecum ligation perforation (CLP) was used to induce sep sis. Treatment group was treated with cistanche deserticola Y. C Ma. (1.25 g?kg -1?d -1, ig) for 14 days before CLP. Animals were killed 12 h or 24 h after CLP an d thmocyte s were collected. The ratio of thmocyte apoptosis and mitochondrial membrane pot ential were determined by the flow cytometry. The ATP activity was detected by s pectrophotography. RESULTS: The rate of thmocyte apoptosis significantly increased 12 h after CLP. The ATP activity decreased 24 h after CLP was significant. The extract of desert living cistanche effectively repressed the apoptosis of th ymocytes and maintained the mitochondrial membrane potential. CONCLUSIONS: The extract of cistanche deserticola Y. C Ma. p rotects thymocytes against apoptosis induced by sepsis. Maintaining of mitochond rial membrane potential may be the protective mechanism.